MALAT-1 Is a Key Regulator of Epithelial–Mesenchymal Transition in Cancer: A Potential Therapeutic Target for Metastasis DOI Open Access
Mohamed Ali Hussein,

Kamyab Valinezhad,

Eman Adel

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(1), P. 234 - 234

Published: Jan. 4, 2024

Metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) is a long intergenic non-coding RNA (lncRNA) located on chr11q13. It overexpressed in several cancers and controls gene expression through chromatin modification, transcriptional regulation, post-transcriptional regulation. Importantly, MALAT-1 stimulates cell proliferation, migration, metastasis serves vital role driving the epithelial-to-mesenchymal transition (EMT), subsequently acquiring cancer stem cell-like properties developing drug resistance. modulates EMT by interacting with various intracellular signaling pathways, notably phosphoinositide 3-kinase (PI3K)/Akt Wnt/β-catenin pathways. also behaves like sponge for microRNAs, preventing their interaction target genes promoting EMT. In addition, we have used bioinformatics online tools to highlight disparities of between normal samples using data from The Cancer Genome Atlas (TCGA). Furthermore, intricate interplay essential targets progression renders it good candidate therapeutic interventions. Several innovative approaches been exploited MALAT-1, such as short hairpin RNAs (shRNAs), antisense oligonucleotides (ASOs), natural products. This review emphasizes modulating metastasis, stemness, chemoresistance different cancers.

Language: Английский

Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways DOI Creative Commons
Yiqun Zhang, Fengju Chen, Darshan S. Chandrashekar

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: May 13, 2022

Abstract Mass-spectrometry-based proteomic data on human tumors—combined with corresponding multi-omics data—present opportunities for systematic and pan-cancer proteogenomic analyses. Here, we assemble a compendium dataset of proteomics 2002 primary tumors from 14 cancer types 17 studies. Protein expression genes broadly correlates mRNA levels or copy number alterations (CNAs) across tumors, but notable exceptions. Based unsupervised clustering, separate into 11 distinct proteome-based subtypes spanning multiple tissue-based types. Two are enriched brain one subtype associating MYC, Wnt, Hippo pathways high CNA burden, another metabolic low burden. Somatic alteration in pathway associates higher activity as inferred by proteome transcriptome data. A substantial fraction cancers shows MYC without gain mutations noncanonical roles MYC. Our proteogenomics survey reveals the interplay between genome tumor lineages.

Language: Английский

Citations

145
Targeting CDK1 in cancer: mechanisms and implications DOI Creative Commons
Qiushi Wang,

Ann M. Bode,

Tianshun Zhang

et al.

npj Precision Oncology, Journal Year: 2023, Volume and Issue: 7(1)

Published: June 13, 2023

Abstract Cyclin dependent kinases (CDKs) are serine/threonine that proposed as promising candidate targets for cancer treatment. These proteins complexed with cyclins play a critical role in cell cycle progression. Most CDKs demonstrate substantially higher expression tissues compared normal and, according to the TCGA database, correlate survival rate multiple types. Deregulation of CDK1 has been shown be closely associated tumorigenesis. activation plays wide range types; and phosphorylation its many substrates greatly influences their function Enrichment interacting Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis was conducted participate oncogenic pathways. This abundance evidence clearly supports target therapy. A number small molecules targeting or have developed evaluated preclinical studies. Notably, some these also subjected human clinical trials. review evaluates mechanisms implications tumorigenesis

Language: Английский

Citations

84
Comprehensive pan-cancer analysis reveals ENC1 as a promising prognostic biomarker for tumor microenvironment and therapeutic responses DOI Creative Commons

Zhenyu Cao,

Jinfeng Zhu, Zicheng Wang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 25, 2024

Accumulating research showed that ENC1 plays a critical role in maintaining the physiological functions. However, little is known about its predicting prognosis and immunotherapy response across cancers. In our results, compared to normal tissues, most cancer tissues exhibit increased expression. We found common type of genetic variation was gene mutation. addition, positive correlation between CNV Moreover, overexpression positively correlated with poor clinical outcomes. The GSEA results closely tumor-promoting biological functions also negatively associated infiltration levels T cells, activated NK B cells. Most immunomodulators are ENC1. Further, we verified inhibition expression suppressed proliferation migration breast cancer, pancreatic glioma conclusion, study demonstrated protumorigenic Additionally, tumor microenvironment features immune checkpoint inhibitors Overall, could serve as promising potential prognostic biomarker various tumors.

Language: Английский

Citations

36
Acidosis activates breast cancer ferroptosis through ZFAND5/SLC3A2 signaling axis and elicits M1 macrophage polarization DOI
Hanchu Xiong,

Yanan Zhai,

Yimei Meng

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 587, P. 216732 - 216732

Published: Feb. 14, 2024

Language: Английский

Citations

21
FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production DOI Creative Commons
Bo Sun, Peng Ding, Yinghui Song

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103302 - 103302

Published: Aug. 6, 2024

Mitochondrial dysfunction and metabolic reprogramming can lead to the development progression of hepatocellular carcinoma (HCC). Ferredoxin 1 (FDX1) is a small mitochondrial protein recent studies have shown that FDX1 plays an important role in tumor cuproptosis, but its HCC still elusive. In this study, we aim investigate expression novel functions HCC.

Language: Английский

Citations

20
Unveiling the role of YARS1 in bladder cancer: A prognostic biomarker and therapeutic target DOI Creative Commons
Yaxuan Wang, Jinfeng Wang, Lu Zhang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(7), P. 1 - 20

Published: March 20, 2024

Abstract YARS is responsible for catalysing the binding of tyrosine to its cognate tRNA and plays a crucial role in basic biosynthesis. However, biological functions bladder cancer remains be proven. We analysed variations YARS1 expression survival using multiple data sets, including TCGA‐BLCA, GSE13507 cancer‐specific tissue microarrays. Furthermore, we explored transcriptome data. Our findings revealed noteworthy correlation between immune infiltration cancer, as determined XCELL algorithm single‐cell analysis. In addition, employed TIDE evaluate responsiveness different cohorts checkpoint therapy. investigated regulatory associations various aspects senescence, ferroptosis stemness. Finally, established ceRNA network that directly linked overall prognosis, can serve prognostic biomarker cancer; interaction with MYC has implications cell Moreover, identified potential therapeutic target cancer.

Language: Английский

Citations

18
Botox-A induced apoptosis and suppressed cell proliferation in fibroblasts pre-treated with breast cancer exosomes DOI Creative Commons

Hossein Sayaf,

Niloufar Salimian,

Mahnaz Mohammadi

et al.

Molecular and Cellular Probes, Journal Year: 2025, Volume and Issue: 79, P. 102007 - 102007

Published: Jan. 6, 2025

Language: Английский

Citations

2
Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development DOI Creative Commons
Haijun Zhang, Lin Zhang, Zhichao Wu

et al.

Cell Division, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 17, 2025

Dysregulation of SF3A3 has been related to the development many cancers. Here, we investigated functional role in hepatocellular carcinoma (HCC). expression HCC tissues and cell lines was examined using RT-qPCR. Changes malignant behavior cells after downregulation were assessed by EdU, colony formation, flow cytometry, wound healing, Transwell invasion assays. Multiple datasets combined identify upstream modifiers SF3A3. The binding relationship between STIL FOXM1 explored co-IP assay, effect on at promoter detected ChIP-qPCR assay. A xenograft tumor model established explore changes tumors vivo, Ki67, GPC3, p53 immunohistochemistry. overexpressed cells, or inhibited promoting p53. An interaction regulated cells. Knockdown further enhanced anti-tumor effects loss vitro whereas overexpression overturned impact vivo. Our findings indicate that STIL/FOXM1 expedites activating SF3A3, which highlights importance as a promising prognostic marker therapeutic target for HCC.

Language: Английский

Citations

2
Comprehensive pan-cancer analysis reveals NTN1 as an immune infiltrate risk factor and its potential prognostic value in SKCM DOI Creative Commons

Fuxiang Luan,

Yuying Cui,

Ruizhe Huang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 25, 2025

Netrin-1 (NTN1) is a laminin-related secreted protein involved in axon guidance and cell migration. Previous research has established significant connection between NTN1 nervous system development. In recent years, mounting evidence indicates that also plays crucial role tumorigenesis tumor progression. For instance, inhibiting been shown to suppress growth epithelial-mesenchymal transition (EMT) characteristics endometrial cancer. To further elucidate the influence of genes on tumors, we utilized variety machine learning techniques found strongly linked multiple cancer types, suggesting it as potential therapeutic target. This study aimed pan-cancer using multi-omics data explore its prognostic biomarker SKCM. Analysis TCGA, GTEx, UALCAN databases revealed differences expression at both mRNA levels. Prognostic value was evaluated through univariate Cox regression Kaplan–Meier methods. Mutation methylation analyses were conducted cBioPortal SMART databases. We identified interacting with correlated STRING GEPIA2, respectively. Subsequently, performed GO KEGG enrichment analyses. The results suggested might be biological processes pathways related development progression, including adhesion, guidance, immune response, various signaling pathways. then explored correlation infiltration well immunotherapy ESTIMATE package, TIMER2.0, TISIDB, TIDE, TIMSO, TCIA. relationship heterogeneity, stemness, DNA methyltransferases, MMR examined. Lastly, constructed nomogram based SKCM investigated association drug sensitivity. significantly associated infiltration, molecular subtypes, clinicopathological features cancers. Genetic analysis Deep deletions most common type alteration. Additionally, positive observed CNAs cancers, showed correlations stromal scores, specific populations. Its predictive for response comparable mutational burden. Furthermore, exhibited methyltransferase genes, genes. SKCM, an independent risk factor demonstrated associations drugs. exhibits substantial clinical utility marker indicator across types. comprehensive provides insights into implications research.

Language: Английский

Citations

2
VSTM2L protects prostate cancer cells against ferroptosis via inhibiting VDAC1 oligomerization and maintaining mitochondria homeostasis DOI Creative Commons
Juan Yang, Lu Xiao, Jinglan Hao

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 29, 2025

Ferroptosis is a form of iron-dependent programmed cell death, which distinct from apoptosis, necrosis, and autophagy. Mitochondria play critical role in initiating amplifying ferroptosis cancer cells. Voltage-Dependent Anion Channel 1 (VDAC1) embedded the mitochondrial outer membrane, exerts roles regulation ferroptosis. However, mechanisms VDAC1 oligomerization regulating are not well elucidated. Here, we identify that binding protein V-Set Transmembrane Domain Containing 2 Like (VSTM2L), mainly localized to mitochondria, positively associated with prostate (PCa) progression, key regulator Moreover, VSTM2L knockdown PCa cells enhances sensitivity RSL3-induced Mechanistically, forms complex hexokinase (HK2), enhancing their affinity preventing oligomerization, thereby inhibiting maintaining mitochondria homeostasis vitro vivo. Collectively, our findings reveal pivotal for mitochondria-localized driving resistance highlight its potential as ferroptosis-inducing therapeutic target treatment PCa.

Language: Английский

Citations

2