The silent spread: exploring diverse metastatic pathways in high-grade serous ovarian cancer

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 5, 2025

High-grade serous ovarian cancer (HGSOC) is a highly aggressive and deadly gynecological cancer, with metastasis being key factor in its poor prognosis. Historically, HGSOC was thought to spread primarily through the peritoneal cavity, but recent research has revealed additional routes of metastasis, including blood lymphatic systems. This review discusses complex processes focusing on immune suppression, stromal reprogramming, role circulating tumor cells blood-based spread. We also explore clinical significance particularly impact patient outcomes. Gaining insight into molecular genetic drivers, such as BRCA mutations interactions within microenvironment, essential for developing targeted treatments. Future studies should aim enhance experimental models, identify early detection markers, investigate novel therapeutic approaches effectively address improve survival.

Language: Английский

Cutting Edge: A Comprehensive Guide to Colorectal Cancer Surgery in Inflammatory Bowel Diseases

Journal of Mind and Medical Sciences, Journal Year: 2025, Volume and Issue: 12(1), P. 6 - 6

Published: March 11, 2025

Over the past two decades, surgical techniques in colorectal cancer (CRC) have improved patient outcomes through precision and reduced invasiveness. Open colectomy, laparoscopic surgery, robotic-assisted procedures, advanced rectal treatments such as total mesorectal excision (TME) transanal TME are discussed this article. Traditional open colectomy offers reliable resection but takes longer to recover. Laparoscopic surgery transformed CRC care by improving oncological outcomes, postoperative pain, recovery. Automated improves laparoscopy’s dexterity, precision, 3D visualisation, making it ideal for pelvic dissections. is gold standard treatment cancer, minimising local recurrence, while TaTME access low-lying tumours, preserving sphincter. In metastatic CRC, palliative procedures help manage blockage, perforation, bleeding. Clinical examples landmark trials show each technique’s efficacy personalised care. Advanced multidisciplinary approaches survival quality of life. Advances require creativity customised surgery.

Language: Английский

Non-hypervascular pancreatic neuroendocrine neoplasms differentiation from CA19-9 negative pancreatic ductal adenocarcinomas based on contrast CT: A large sample series

European Journal of Radiology, Journal Year: 2025, Volume and Issue: unknown, P. 112095 - 112095

Published: April 1, 2025

Language: Английский