Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice DOI Creative Commons
Matthew T. Birnie, Annabel K. Short, Gregory de Carvalho

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 25, 2023

Disrupted operations of the reward circuit underlie major emotional disorders, including depression, which commonly arise following early life stress / adversity (ELA). However, how ELA enduringly impacts functions remains unclear. We characterize a stress-sensitive projection connecting basolateral amygdala (BLA) and nucleus accumbens (NAc) that co-expresses GABA stress-reactive neuropeptide corticotropin-releasing hormone (CRH). identify crucial role for this in executing disrupted behaviors provoked by ELA: chemogenetic optogenetic stimulation control male mice suppresses several behaviors, recapitulating deficits resulting from demonstrating pathway's contributions to normal behaviors. In adult mice, inhibiting-but not stimulating-the projection, restores typical yet has little effect controls, indicating ELA-induced maladaptive plasticity reward-circuit component. Thus, we discover stress-sensitive, inhibiting BLA → NAc with unique molecular features, may provide intervention targets disabling mental illnesses.

Language: Английский

The neural basis of reversal learning: An updated perspective DOI
Alicia Izquierdo, Jonathan L. Brigman, Anna K. Radke

et al.

Neuroscience, Journal Year: 2016, Volume and Issue: 345, P. 12 - 26

Published: March 12, 2016

Language: Английский

Citations

574
Neurocomputational mechanisms underlying subjective valuation of effort costs DOI Creative Commons
Trevor T.‐J. Chong, Matthew A J Apps, Kathrin Giehl

et al.

PLoS Biology, Journal Year: 2017, Volume and Issue: 15(2), P. e1002598 - e1002598

Published: Feb. 24, 2017

In everyday life, we have to decide whether it is worth exerting effort obtain rewards. Effort can be experienced in different domains, with some tasks requiring significant cognitive demand and others being more physically effortful. The motivation exert for reward highly subjective varies considerably across the domains of behaviour. However, very little known about computational or neural basis how costs are subjectively weighed against Is there a common, domain-general system brain areas that evaluates all benefits? Here, used modelling functional magnetic resonance imaging (fMRI) examine mechanisms underlying value processing both physical domains. Participants were trained on two novel parametrically varied either effort. During fMRI, participants indicated their preferences between fixed low-effort/low-reward option variable higher-effort/higher-reward offer each domain. Critically, devaluation by was subserved common network areas, including dorsomedial dorsolateral prefrontal cortex, intraparietal sulcus, anterior insula. Activity within these also covaried negatively positively effort, suggesting an integration parameters areas. Additionally, amygdala appeared play unique, domain-specific role rewards associated These results first reveal neurocomputational cost–benefit valuation provide insight into multidimensional nature motivation.

Language: Английский

Citations

380
Adaptive learning under expected and unexpected uncertainty DOI
Alireza Soltani, Alicia Izquierdo

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(10), P. 635 - 644

Published: May 30, 2019

Language: Английский

Citations

262
Functional Heterogeneity within Rat Orbitofrontal Cortex in Reward Learning and Decision Making DOI Creative Commons
Alicia Izquierdo

Journal of Neuroscience, Journal Year: 2017, Volume and Issue: 37(44), P. 10529 - 10540

Published: Nov. 1, 2017

Rat orbitofrontal cortex (OFC) is located in the dorsal bank of rhinal sulcus, and divided into medial orbital area, ventral ventrolateral lateral dorsolateral agranular insular areas. Over past 20 years, there has been a marked increase number publications focused on functions rat OFC. While collectively this extensive body work provided great insight OFC, leading to theoretical computational models its functions, one issue that emerged relates what defined as OFC because targeting region can be quite variable between studies appetitive behavior, even within same species. Also apparent an oversampling undersampling certain subregions for study, will demonstrated here. The intent Viewpoint summarize given diversity groups refer “OFC,” integrate these with findings recent anatomical studies. primary aim help discern reward learning decision-making, clearing course future empirical work.

Language: Английский

Citations

248
Linking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience DOI
Giorgia Michelini, Isabella M. Palumbo, Colin G. DeYoung

et al.

Clinical Psychology Review, Journal Year: 2021, Volume and Issue: 86, P. 102025 - 102025

Published: March 24, 2021

Language: Английский

Citations

207
Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain DOI
Matthew N. Tran, Kristen R. Maynard, Abby Spangler

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(19), P. 3088 - 3103.e5

Published: Sept. 27, 2021

Language: Английский

Citations

187
Motivational neural circuits underlying reinforcement learning DOI
Bruno B. Averbeck, Vincent D. Costa

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(4), P. 505 - 512

Published: March 29, 2017

Language: Английский

Citations

176
The effects of early life stress on reward processing DOI
Andrew M. Novick, Mateus Luz Levandowski, Laura E. Laumann

et al.

Journal of Psychiatric Research, Journal Year: 2018, Volume and Issue: 101, P. 80 - 103

Published: Feb. 13, 2018

Language: Английский

Citations

170
Multidimensional processing in the amygdala DOI
Katalin M. Gothard

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(10), P. 565 - 575

Published: Aug. 24, 2020

Language: Английский

Citations

147
Effects of urban living environments on mental health in adults DOI Creative Commons
Jiayuan Xu, Nana Liu, Elli Polemiti

et al.

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(6), P. 1456 - 1467

Published: June 1, 2023

Abstract Urban-living individuals are exposed to many environmental factors that may combine and interact influence mental health. While individual of an urban environment have been investigated in isolation, no attempt has made model how complex, real-life exposure living the city relates brain health, this is moderated by genetic factors. Using data 156,075 participants from UK Biobank, we carried out sparse canonical correlation analyses investigate relationships between environments psychiatric symptoms. We found profile social deprivation, air pollution, street network land-use density was positively correlated with affective symptom group ( r = 0.22, P perm < 0.001), mediated volume differences consistent reward processing, genes enriched for stress response, including CRHR1 , explaining 2.01% variance differences. Protective such as greenness generous destination accessibility were negatively anxiety 0.10, regions necessary emotion regulation EXD3 1.65% variance. The third emotional instability 0.03, 0.001). Our findings suggest different profiles specific groups through distinct neurobiological pathways.

Language: Английский

Citations

87