Cannabis Use in Adolescence: A Review of Neuroimaging Findings DOI
Yann Chye, Erynn Christensen, Murat Yücel

et al.

Journal of Dual Diagnosis, Journal Year: 2019, Volume and Issue: 16(1), P. 83 - 105

Published: July 16, 2019

Objective: Shifting policies and widespread acceptance of cannabis for medical and/or recreational purposes have fueled worries increased initiation use in adolescents. In particular, the adolescent period is thought to be associated with an susceptibility potential harms repeated use, due being a critical neuromaturational events brain. This review investigates neuroimaging evidence brain attributable use. Methods: PubMed Scopus searches were conducted empirical articles that examined effects both users adult user studies explored effect age at onset on Results: We found 43 (structural functional magnetic resonance imaging) 20 link between users. Studies relative nonusers mainly implicate frontal parietal regions activation relation inhibitory control, reward, memory. However, adults are more mixed, many which did not observe imaging metrics. Conclusions: While there some compromised frontoparietal structure function it remains unclear whether observed specifically or general use–related factors such as depressive symptoms. The contribution chronicity will comprehensively prospective, longitudinal rigorous measures (dosage, exposure, dependence, constituent compounds cannabinoid levels).

Language: Английский

Hepatic Cannabinoid Signaling in the Regulation of Alcohol-Associated Liver Disease DOI Open Access
Ke‐Ya Yang

Alcohol research, Journal Year: 2021, Volume and Issue: 41(1)

Published: Jan. 1, 2021

Alcohol and cannabis are the most commonly used substances during adolescence typically initiated this sensitive neurodevelopmental period. The aim of review is to provide a comprehensive overview recent literature focused on understanding how these affect developing brain.Articles included in were identified by entering 30 search terms substance use, adolescence, neurodevelopment into MEDLINE, Embase, PsycINFO, ProQuest Central, Web Science. Studies eligible for inclusion if they longitudinally examined effect adolescent alcohol and/or use structural or functional outcomes 50 more participants.More than 700 articles captured search, 43 longitudinal studies met criteria, including 18 13 12 co-use.Existing suggest heavy related small moderate disruptions brain structure function, as well neurocognitive impairment. effects include widespread decreases gray matter volume cortical thickness across time; slowed white growth poorer integrity; disrupted network efficiency; impulse attentional control, learning, memory, visuospatial processing, psychomotor speed. severity some dependent dose. Heavy very associated with decreased subcortical increased frontoparietal thickness, development, executive functioning IQ compared non-using controls. Overall, co-use findings pronounced use. Several limitations exist literature. Sample sizes relatively demographically homogenous, significant heterogeneity patterns methodologies studies. More research needed clarify dosing interactions between substances, sociodemographic environmental factors, outcomes. Larger studies, already underway, will help relationship development

Language: Английский

Citations

37
Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants DOI Open Access
Sarah Lichenstein,

Nick Manco,

Lora M. Cope

et al.

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(5), P. 1000 - 1028

Published: Nov. 27, 2021

Language: Английский

Citations

36
Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis DOI Creative Commons
Kenneth Blum, Jag Khalsa, Jean Lud Cadet

et al.

Frontiers in Psychiatry, Journal Year: 2021, Volume and Issue: 12

Published: March 30, 2021

Over years, the regular use of cannabis has substantially increased among young adults, as indicated by rise in disorder (CUD), with an estimated prevalence 8. 3% United States. Research shows that exposure to is associated hypodopaminergic anhedonia (depression), cognitive decline, poor memory, inattention, impaired learning performance, reduced dopamine brain response-associated emotionality, and addiction severity adults. The medicine community increasing concern because high content delta-9-tetrahydrocannabinol (THC) currently found oral vaping products, effects may become more pronounced adults who these products. Preliminary research suggests it possible induce 'dopamine homeostasis,' is, restore function upregulation proposed compound normalize behavior chronic users cannabis-induced (depression) decline. This psychological, neurobiological, anatomical, genetic, epigenetic also could provide evidence for development appropriate policy regarding decriminalization recreational use.

Language: Английский

Citations

29
Patterns of brain function associated with cannabis cue-reactivity in regular cannabis users: a systematic review of fMRI studies DOI Creative Commons

Hannah Sehl,

Gill Terrett, Lisa‐Marie Greenwood

et al.

Psychopharmacology, Journal Year: 2021, Volume and Issue: 238(10), P. 2709 - 2728

Published: Sept. 10, 2021

Abstract Rationale Regular cannabis use (i.e. ≥ monthly) is highly prevalent, with past year being reported by ~ 200 million people globally.High reactivity to cues a key feature of regular and has been ascribed greater exposure craving, but the underlying neurobiology yet be systematically integrated. Objectives We aim summarise findings from fMRI studies which examined brain function in users while exposed vs neutral stimuli during cue-reactivity task. Methods A systematic search PsycINFO, PubMed Scopus databases was pre-registered PROSPERO (CRD42020171750) conducted following PRISMA guidelines. Eighteen met inclusion/exclusion criteria. Samples comprised 918 participants (340 female) aged 16–38 years. Of these, 603 were users, 315 controls. Results The literature consistently activity three areas: striatum, prefrontal (anterior cingulate, middle frontal) parietal cortex (posterior cingulate/precuneus) additional regions (hippocampus, amygdala, thalamus, occipital cortex). Preliminary correlations emerged between craving partially overlapping (amygdala, orbitofrontal ). Conclusions Exposure cannabis-cues may elicit thus trigger cravings craving. Standardised longitudinal assessments related problems are required profile precision cue-reactivity, its role predicting relapse.

Language: Английский

Citations

28
Cannabis Use in Adolescence: A Review of Neuroimaging Findings DOI
Yann Chye, Erynn Christensen, Murat Yücel

et al.

Journal of Dual Diagnosis, Journal Year: 2019, Volume and Issue: 16(1), P. 83 - 105

Published: July 16, 2019

Objective: Shifting policies and widespread acceptance of cannabis for medical and/or recreational purposes have fueled worries increased initiation use in adolescents. In particular, the adolescent period is thought to be associated with an susceptibility potential harms repeated use, due being a critical neuromaturational events brain. This review investigates neuroimaging evidence brain attributable use. Methods: PubMed Scopus searches were conducted empirical articles that examined effects both users adult user studies explored effect age at onset on Results: We found 43 (structural functional magnetic resonance imaging) 20 link between users. Studies relative nonusers mainly implicate frontal parietal regions activation relation inhibitory control, reward, memory. However, adults are more mixed, many which did not observe imaging metrics. Conclusions: While there some compromised frontoparietal structure function it remains unclear whether observed specifically or general use–related factors such as depressive symptoms. The contribution chronicity will comprehensively prospective, longitudinal rigorous measures (dosage, exposure, dependence, constituent compounds cannabinoid levels).

Language: Английский

Citations

34