Developmental Cognitive Neuroscience,
Journal Year:
2020,
Volume and Issue:
43, P. 100791 - 100791
Published: April 27, 2020
Reduced
activation
of
positive
valence
systems
(PVS),
including
blunted
neural
and
physiological
responses
to
pleasant
stimuli
rewards,
has
been
shown
prospectively
predict
the
development
psychopathology.
Yet,
little
is
known
about
how
reduced
PVS
emerges
across
or
what
implications
it
for
prevention.
We
review
genetic,
temperament,
parenting,
naturalistic
laboratory
stress
research
on
measures
outline
developmentally-informed
models
trajectories
activation.
function
partly
heritable
appears
reflect
individual
differences
in
early-emerging
temperament
traits.
Although
lab-induced
stressors
blunt
activation,
effects
parenting
are
mixed
depend
type
stressor,
developmental
timing,
interactions
amongst
risk
factors.
propose
that
there
may
be
multiple,
dynamic
which
combinations
genes,
exposure
severe,
prolonged,
uncontrollable
exert
direct
interactive
function.
Critically,
these
factors
alter
and/or
sensitivity
proximal
stressors.
Distinct
converge
such
proceeds
along
a
typical,
accelerated,
chronically
low,
stress-reactive
trajectory.
Finally,
we
present
directions
future
with
translational
implications.
PEDIATRICS,
Journal Year:
2019,
Volume and Issue:
143(5)
Published: April 15, 2019
The
phenomenon
of
teen
sexting
emerged
as
a
result
the
proliferation
digital
technology.
More
than
40
studies
have
established
that
occurs
relatively
frequently
and
is
rising
trend,
commensurate
with
ubiquity
smartphone
ownership
in
teens.
Studies
shown
associated
incidences
increased
sexual
behavior.
US
state
laws
on
vary
widely,
from
decriminalization
to
misdemeanor
charges
or
prosecution
for
child
pornography
harsh
sentences.
Teen
behavior
invention
outpaced
development
new
laws,
this
has
potential
dire
legal
ramifications
Separating
consensual
nonconsensual
actual
critical
next
step
law
enforcement
agencies
policy
makers
catch
up
In
article,
we
argue
teen-to-teen
does
not
warrant
involvement
but
rather
health
education
issue
better
addressed
at
home,
schools,
primary
care.
Frontiers in Psychiatry,
Journal Year:
2019,
Volume and Issue:
10
Published: April 16, 2019
Background:
Analyses
of
resting-state
functional
magnetic
resonance
imaging
(rs-fMRI)
have
been
performed
to
investigate
pathophysiological
changes
in
the
brains
patients
with
autism
spectrum
disorder
(ASD)
relative
typically
developing
controls
(CTLs).
However,
results
these
previous
studies,
which
reported
mixed
patterns
hypo-
and
hyperconnectivity,
are
controversial,
likely
due
small
sample
sizes
limited
age
range
included
participants.
Methods:
To
overcome
this
issue,
we
analyzed
multisite
neuroimaging
data
from
a
large
(n
=
626)
male
participants
aged
between
5
29
years
(mean
13
years).
The
rs-fMRI
were
preprocessed
using
SPM12
DPARSF
software,
signal
90
brain
regions
extracted.
Multiple
linear
regression
was
used
exclude
effect
site
differences
connectivity
data.
Subcortical-cortical
computed
connectivities
hippocampus,
amygdala,
caudate
nucleus,
putamen,
pallidum,
thalamus.
Eighty-eight
each
structure
compared
ASD
CTLs
multiple
group,
age,
×
group
interactions,
head
movement
parameters,
overall
as
variables.
Results:
After
correcting
for
comparisons,
exhibited
significant
increases
thalamus
19
cortical
distributed
throughout
fronto-parietal
lobes,
including
temporo-parietal
junction
posterior
cingulate
cortices.
In
addition,
there
decreases
amygdala
six
regions.
mean
size
hyperconnectivity
(0.25)
greater
than
that
hypoconnectivity
(0.08).
No
other
subcortical
structures
showed
differences.
A
group-by-age
interaction
observed
motor-somatosensory
areas.
Conclusions:
These
demonstrate
associated
more
related
thalamocortical
amygdala-cortical
hypoconnectivity.
Future
studies
should
examine
full
sets
clinical
behavioral
symptoms
combination
explore
possible
biomarkers
ASD.
Translational Psychiatry,
Journal Year:
2019,
Volume and Issue:
9(1)
Published: Feb. 25, 2019
This
study
examines
the
effects
of
puberty
and
sex
on
intrinsic
functional
connectivity
(iFC)
brain
networks,
with
a
focus
default-mode
network
(DMN).
Consistently
implicated
in
depressive
disorders,
DMN's
function
may
interact
development
these
whose
onsets
peak
adolescence,
which
show
strong
disproportionality
(females
>
males).
The
main
question
concerns
how
DMN
evolves
as
sex.
These
are
expected
to
involve
within-
between-network
iFC,
particularly,
salience
central-executive
consistent
Triple-Network
Model.
Resting-state
scans
an
adolescent
community
sample
(n
=
304,
male/female:
157/147;
mean/std
age:
14.6/0.41
years),
from
IMAGEN
database,
were
analyzed
using
AFNI
software
suite
data
reduction
strategy
for
Three
midline
regions
(medial
prefrontal,
pregenual
anterior
cingulate,
posterior
cingulate),
within
consistently
mood
selected
seeds.
Within-
clusters
iFC
changed
pubertal
maturation
differently
boys
girls
(puberty-X-sex).
Specifically,
predicted
weaker
stronger
boys.
Finally,
was
than
independently
puberty.
Brain-behavior
associations
indicated
that
lower
cingulate
seed
higher
internalizing
symptoms
at
2-year
follow-up.
In
conclusion,
signal
disconnections
among
circuits
supporting
regulation,
conferring
risk
disorders.
Developmental Cognitive Neuroscience,
Journal Year:
2020,
Volume and Issue:
43, P. 100791 - 100791
Published: April 27, 2020
Reduced
activation
of
positive
valence
systems
(PVS),
including
blunted
neural
and
physiological
responses
to
pleasant
stimuli
rewards,
has
been
shown
prospectively
predict
the
development
psychopathology.
Yet,
little
is
known
about
how
reduced
PVS
emerges
across
or
what
implications
it
for
prevention.
We
review
genetic,
temperament,
parenting,
naturalistic
laboratory
stress
research
on
measures
outline
developmentally-informed
models
trajectories
activation.
function
partly
heritable
appears
reflect
individual
differences
in
early-emerging
temperament
traits.
Although
lab-induced
stressors
blunt
activation,
effects
parenting
are
mixed
depend
type
stressor,
developmental
timing,
interactions
amongst
risk
factors.
propose
that
there
may
be
multiple,
dynamic
which
combinations
genes,
exposure
severe,
prolonged,
uncontrollable
exert
direct
interactive
function.
Critically,
these
factors
alter
and/or
sensitivity
proximal
stressors.
Distinct
converge
such
proceeds
along
a
typical,
accelerated,
chronically
low,
stress-reactive
trajectory.
Finally,
we
present
directions
future
with
translational
implications.