Food Frontiers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 16, 2024
Abstract
Flavonoids
are
a
major
class
of
polyphenolic
compounds
that
occur
naturally
in
plants
and
widely
distributed
various
dietary
products.
exhibit
prominent
physicochemical
properties
biological
activities,
thereby
garnering
considerable
attention.
Notably,
the
functionalities
flavonoids
structurally
dependent.
Variations
chemical
structure
lead
to
differences
characteristics
among
different
flavonoid
types.
Structural
alterations
can
modify
these
characteristics,
influencing
activities
mechanisms
action.
However,
structural
variations
their
implication
have
not
been
comprehensively
elucidated.
In
this
review,
we
outline
flavonoids,
discuss
biosynthesis,
vivo
digestion,
absorption,
particularly
emphasize
diverse
action
associated
with
structures.
By
summarizing
current
scientific
findings,
aim
elucidate
structure–activity
relationships
provide
theoretical
basis
for
development
new
applications,
which
will
help
target
design
functional
molecules
moieties
food
pharmaceutical
industries
use
drug
development.
Practical
Application
:
Understanding
guide
products
supplements
targeted
health
benefits.
leveraging
knowledge
relationships,
food,
innovate
formulations
enhance
bioavailability
efficacy,
potentially
leading
creation
tailored
specific
conditions
or
needs.
This
research
lays
groundwork
novel
flavonoid‐based
interventions
aimed
at
promoting
human
well‐being.
Frontiers in Veterinary Science,
Journal Year:
2025,
Volume and Issue:
11
Published: Jan. 22, 2025
This
study
aims
to
examine
the
effects
of
Ferula
root
powder
(FRP)
on
performance,
egg
quality,
oxidant/antioxidant
levels,
some
serum
hormone/biochemical
parameters,
and
physical
properties
oviduct
in
laying
hens.
A
total
72
(8
replicates,
3
hens/subgroup)
hens
(Nick
Brown,
30
weeks)
were
divided
into
three
groups
(FRP-0,
FRP-1,
FRP-2).
During
9-week
trial,
FRP-0
(control)
was
fed
with
a
basal
diet
(16.88%
crude
protein,
2,725
kcal/kg
metabolizable
energy).
FRP-1
FRP-2
groups,
however,
supplemented
1
g/kg
2
FRP,
respectively.
The
results
showed
that
hormone
(estradiol,
progesterone)
internal
organ
weights
not
affected
by
FRP
supplementation.
In
comparison
control
group,
higher
yolk
height
index
found
FRP-added
groups.
albumen
pH
have
decreased
group.
DPPH
radical
scavenging
activity
increased
yolk.
TBARs
value
Serum
triglyceride
cholesterol
levels
group
FRP-2.
Moreover,
uterus
length
FRP-supplemented
Given
achieved,
it
determined
does
significant
estrogenic
effect.
However,
can
be
utilized
prevent
lipid
oxidation
for
its
hypocholesterolemic
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 1846 - 1846
Published: Feb. 21, 2025
The
association
between
17β-estradiol
(E2)
deprivation,
seen
in
menopause,
and
a
risk
for
developing
glaucoma
has
been
shown.
Thus,
exogenous
supplementation
of
E2
may
protect
against
retinal
ganglion
cell
(RGC)
degradation
vision
loss.
Here,
we
investigated
the
utility
topical
10β,17β-dihydroxyestra-1,4-dien-3-one
(DHED),
prodrug
that
selectively
produces
neuroprotective
hormone
retina,
on
visual
function
after
optic
nerve
crush
(ONC)
ovariectomy
(OVX).
We
used
female
Brown
Norway
rats
underwent
either
Sham
or
OVX
surgeries.
After
ONC,
animals
received
DHED
vehicle
eye
drops
12
weeks.
Visual
function,
via
optomotor
reflex,
thickness,
optical
coherence
tomography,
were
followed
longitudinally.
Afterward,
performed
mass
spectrometry-based
label-free
retina
proteomics
to
survey
protein
interaction
networks
our
selected
animal
model
identify
E2-responsive
proteins
neurodegeneration.
found
ONC
with
caused
significant
decline
functions
ameliorated
by
treatments.
Discovery-driven
identified
numerous
associated
neurodegenerative
processes
due
remediated
drops.
Altogether,
three-pronged
phenotypic
preclinical
evaluation
+
reveals
therapeutic
potential
prevent
deficits
glaucomatous
injury.
Brazilian Journal of Medical and Biological Research,
Journal Year:
2025,
Volume and Issue:
58
Published: Jan. 1, 2025
During
the
climacteric
period,
decline
in
ovarian
hormones
leads
to
changes
lipid
profile.
Physical
exercise
is
main
non-pharmacological
recommendation
for
controlling
levels.
However,
effects
on
profile
perimenopausal
and
postmenopausal
women
are
incipient
inconclusive.
In
this
context,
we
searched
Embase,
PubMed,
Scopus,
Web
of
Science
databases
randomized
clinical
trials
these
women.
We
excluded
studies
that
did
not
specify
criteria
classifying
phase,
involved
undergoing
hormone
replacement
therapy,
or
examined
combined
treatments
acute
physical
exercise.
The
meta-analysis
indicated
general
increased
high-density
lipoprotein
cholesterol
(HDL-C)
levels
(mean
difference
[MD]=4.89;
95%
confidence
interval
[95%CI]=0.97
8.81)
For
obese
women,
16
weeks
aerobic
training
HDL-C
(MD=3.88;
95%CI=0.56
7.20)
reduced
total
(MD=-22.36;
95%CI=-29.67
-15.05)
low-density
(LDL-C)
(MD=-17.86;
95%CI=-25.97
-9.75),
whereas
12
resistance
(MD=4.20;
95%CI=1.16
7.23)
decreased
triglycerides
(MD=-14.86;
95%CI=-26.62
-3.09)
LDL-C
(MD=-16.36;
95%CI=-28.05
-4.67).
Overall,
results
showed
regulated
profiles
Specifically,
improved
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2390 - 2390
Published: March 7, 2025
Cancer,
a
worldwide
problem
and
one
of
the
leading
causes
death
due
to
uncontrolled
cell
proliferation,
can
be
caused
by
various
factors,
such
as
genetic
environmental
factors.
Apoptosis
is
programmed
mechanism
that
eliminates
abnormal
cells
or
renews
cells.
There
are
two
main
apoptotic
pathways:
intrinsic
extrinsic
pathways.
These
pathways
affected
signaling
in
cancer,
PI3K/AKT,
MAPK,
Wnt,
JAK/STAT
Numerous
approaches
cancer
treatment
have
been
studied,
among
them,
natural
compounds
actively
researched.
Flavonoids
from
fruits
vegetables
studied
for
their
anti-cancer
effects.
Isoflavones,
subclasses
flavonoids,
usually
found
soy
food
legumes
effective
several
bioactive
functions.
The
well-known
isoflavones
genistein,
daidzein,
glycitein.
Irigenin
iridin
extracted
Iris
family.
Both
irigenin
currently
being
anti-inflammation,
antioxidant,
inducing
apoptosis.
In
this
review,
we
summarized
five
isoflavones,
glycitein,
irigenin,
effects
on
three
different
cancers:
breast
prostate
gastric
cancer.
