Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: April 6, 2023
Abstract
Plasticity
is
the
ability
to
modify
brain
and
behavior
allows
transition
from
psychopathology
mental
wellbeing.
High
plasticity
has
been
associated
high
susceptibility
contextual
factors,
e.g.,
living
conditions,
which
ultimately
drive
outcome.
Here,
we
exploited
network
analysis
show
that
–
i.e.,
depression
score
can
be
assessed
by
measuring
symptom
connectivity:
weaker
connectivity,
higher
plasticity,
resulting
in
a
greater
modification
mood
symptoms.
We
analyzed
STAR*D
dataset
proved
connectivity
strength
at
baseline
responder
compared
non-responder
patients.
Moreover,
was
inversely
correlated
with
improvement
(Pearson's
r=-0.87)
change
according
context
r=-0.77).
This
operationalization
of
provides
mathematical
tool
investigate
predict
resilience,
vulnerability
recovery,
develop
novel
approaches
for
prevention
treatment
depression.
American Journal of Psychiatry,
Journal Year:
2025,
Volume and Issue:
182(1), P. 47 - 53
Published: Jan. 1, 2025
The
last
few
years
have
seen
exponential
growth
in
interest,
investment,
advocacy,
and
research
into
psychedelics
as
therapeutics.
This
reflects
an
optimism
about
the
potential
promise
of
As
with
all
therapeutic
interventions,
is
needed
not
only
their
benefits
but
also
risks.
Indeed,
when
substances
are
scrutinized
over
time,
especially
broad
populations
psychiatric
medical
comorbidities
typically
excluded
from
clinical
trials,
applied
less
well-regulated
or
controlled
settings,
a
greater
understanding
cautions
emerges.
Here,
we
review
literature
on
known
harms,
including
enduring
perceptual
disturbances;
triggering
enhancing
risk
for
onset
mania
psychosis;
overuse,
misuse,
dependence;
challenging
experiences
"bad
trips";
risks
associated
increased
neuroplastic
potential;
acute
cumulative
cardiovascular
effects.
Each
these
issues
addressed
this
review,
along
call
continued
research,
recommendations
further
monitoring.
Translational Psychiatry,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: July 11, 2022
The
serotonin-transporter-linked
promoter
region
(5-HTTLPR)
has
been
widely
investigated
as
contributing
to
depression
vulnerability.
Nevertheless,
empirical
research
provides
wide
contrasting
findings
regarding
its
involvement
in
the
etiopathogenesis
of
disorder.
Our
hypothesis
was
that
such
discrepancy
can
be
explained
considering
time
moderating
factor.
We
explored
this
hypothesis,
exploiting
a
meta
analytic
approach.
searched
PubMed,
PsychoINFO,
Scopus
and
EMBASE
databases
1096
studies
were
identified
screened,
resulting
22
included
meta-analyses.
effect
5-HTTLPR
x
stress
interaction
on
risk
found
moderated
by
following
temporal
factors:
duration
(i.e.
chronic
vs.
acute)
interval
between
end
assessment
within
1
year
more
than
year).
When
stratifying
for
stress,
emerged
only
case
with
significant
subgroup
difference
(p
=
0.004).
stratification
according
revealed
intervals
year,
though
no
subgroups
found.
critical
role
clearly
when
stress:
confirmed
exclusively
0.01).
These
results
show
is
dynamic
process,
producing
different
effects
at
points,
indirectly
confirm
s-allele
carriers
are
both
higher
capable
recover
from
depression.
Overall,
these
expand
current
view
interplay
adding
dimension,
three-way
interaction:
gene
environment
time.
European Journal of Neuroscience,
Journal Year:
2024,
Volume and Issue:
60(5), P. 4687 - 4706
Published: April 1, 2024
Abstract
Notwithstanding
the
huge
progress
in
molecular
and
cellular
neuroscience,
our
ability
to
understand
brain
develop
effective
treatments
promoting
mental
health
is
still
limited.
This
can
be
partially
ascribed
reductionist,
deterministic
mechanistic
approaches
neuroscience
that
struggle
with
complexity
of
central
nervous
system.
Here,
I
introduce
Context
theory
constrained
systems
proposing
a
novel
role
contextual
factors
genetic,
neural
substrates
determining
functioning
behavior.
entails
key
conceptual
implications.
First,
context
main
driver
behavior
states.
Second,
substrates,
from
genes
areas,
have
no
direct
causal
link
complex
behavioral
responses
as
they
combined
multiple
ways
produce
same
response
different
impinge
on
substrates.
Third,
biological
play
distinct
roles
behavior:
drives
behavior,
constrain
repertoire
implemented.
Fourth,
since
interface
between
system
environment,
it
privileged
level
control
orchestration
functioning.
Such
implications
are
illustrated
through
Kitchen
metaphor
brain.
theoretical
framework
calls
for
revision
concepts
psychiatry,
including
causality,
specificity
individuality.
Moreover,
at
clinical
level,
proposes
inducing
changes
interventions
having
highest
impact
reorganize
human
mind
achieve
long‐lasting
improvement
health.
Translational Psychiatry,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 28, 2025
Predicting
disease
trajectories
in
patients
with
major
depressive
disorder
(MDD)
can
allow
designing
personalized
therapeutic
strategies.
In
this
study,
we
aimed
to
show
that
measuring
patients'
plasticity
–
is
the
susceptibility
modify
mental
state
identifies
at
baseline
who
will
recover,
anticipating
time
transition
wellbeing.
We
conducted
a
secondary
analysis
two
randomized
clinical
trials,
STAR*D
and
CO-MED.
Symptom
severity
was
assessed
using
Quick
Inventory
of
Depressive
Symptomatology
while
context
measured
enrollment
Quality-of-Life
Enjoyment
Satisfaction
Questionnaire.
Patients
were
retrospectively
grouped
based
on
both
their
response
or
remission
levels
through
network-based
mathematical
approach
operationalizes
as
inverse
symptom
network
connectivity
strength.
The
results
anticipate
remission.
Connectivity
strength
among
symptoms
significantly
lower
thus
higher
experiencing
fast
recovery.
When
interplay
between
considered,
are
predictive
only
subjects
favorable
context,
confirming
magnifies
influence
mood.
conclusion,
assessment
holds
promise
for
predicting
MDD
trajectories,
potentially
informing
design
treatments
interventions.
combination
high
experience
emerges
critical
achieve
World Journal of Psychiatry,
Journal Year:
2025,
Volume and Issue:
15(3)
Published: Feb. 26, 2025
Depression
and
anxiety
are
prevalent
psychological
challenges
among
patients
with
adolescent
idiopathic
scoliosis
(AIS),
affecting
individuals
across
both
sex
age
groups.
To
explore
the
network
structure
of
depression
symptoms,
a
focus
on
identifying
differences
at
symptom
level
between
subgroups.
A
total
1955
participants
diagnosed
AIS
aged
10-18
years
were
assessed
using
Patient
Health
Questionnaire
Scale
(PHO-9)
Generalized
Anxiety
Disorder
(GAD-7),
765
exhibiting
PHQ-9
or
GAD-7
scores
≥
5
enrolled
in
our
study.
Network
analysis
comparison
tests
utilized
to
construct
compare
depression-anxiety
symptoms
networks
The
results
revealed
GAD3
"Excessive
worry"
PHQ2
"Sad
mood"
most
significant
central
all
subgroups,
while
had
higher
strength
than
lower
group.
In
comparisons,
female
exhibited
tighter
connectivity,
especially
GAD6
"Irritability"
GAD2
"Uncontrollable
worry",
only
PHQ3
"Sleep"
PHQ9
"Suicidal
ideation"
local
Several
interventions
targeting
excessive
worry
sad
mood
could
reduce
risk
population.
Furthermore,
specific
females,
along
sleep
disturbances
suicidal
ideation
group,
should
be
addressed
an
early
stage
prevent
disruptions
mental
health
trajectories.
Neuroscience Applied,
Journal Year:
2023,
Volume and Issue:
3, P. 103923 - 103923
Published: Nov. 8, 2023
Immune
alterations
have
been
widely
implicated
in
the
onset,
progression,
and
treatment
of
major
depressive
disorder.
However,
our
comprehension
intricate
link
between
immune
function
psychopathology
remains
fragmented
limited.
Here
we
propose
that
interplay
neural
plasticity
is
key
transition
from
to
mental
wellbeing.
In
particular,
any
deviation
toward
an
extreme
activation
or
suppression
leads
a
dysregulation
molecular
machinery
underlying
plasticity.
Therefore,
pro–inflammatory
conditions
depressed
patients
are
associated
with
impaired
plasticity,
limiting
potential
recover.
Patient's
confinement
within
their
pathological
state
here
referred
as
inflammatory
trap
depression.
The
normalization
reinstates
thereby
restoring
capacity
attain
Since
growing
evidence
showing
reinstating
does
not
lead
improvement
per
se
but
increases
likelihood
recovery,
combining
activity
environmental
promoting
wellbeing
critical
achieve
beneficial
outcome.
This
theoretical
framework
allows
reconcile
conceptual
discrepancies
immunopsychiatry
such
egg
chicken
nor
sufficient
necessary
issues.
Overall,
tuning
system
promote
promising
approach
refine
develop
innovative
therapeutic
strategies
for
depression,
leading
personalized
highly
effective
treatments.
