Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Medical Hypotheses, Journal Year: 2024, Volume and Issue: 189, P. 111403 - 111403
Published: June 12, 2024
Major depressive disorder (MDD) is characterized by symptoms such as low mood and anhedonia related to altered dopamine transmission in the reward system. In addition, approximately one-third of patients with MDD develop treatment-resistance pharmaceutical treatment, necessitating alternative therapeutic strategies. While non-invasive brain stimulation (NIBS) holds promise for improving treatment-resistant MDD, remission rates are still relatively modest. It has been demonstrated that NIBS effects not only depend properties but also "state-dependent", meaning when engage specific tasks or states involve similar neural networks targeted NIBS, a synergistic additive effect may occur. Therefore, recent strategy improve treatment outcomes combine other types interventions targeting same network. Numerous studies have clinically meaningful antidepressant combined psychotherapy, cognitive-behavioral approaches, cognitive remediation programs MDD. However, widespread use this combination be hindered barriers cost accessibility both clinicians patients. Alternatively, sensory-based alone (such music therapy exposure odors) represent promising, easy-to-implement, cost-effective innovative approach These known activate meso-cortico-limbic system, triggering release, modulating dopaminergic tone various structures, what observed NIBS. paper, hypothesis combining compelling alleviating tested. Specifically, it hypothesized dual activation system induced interventions, concurrent application will result effect, ultimately leading enhanced alleviation symptoms.
Language: Английский
Citations
1
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1067 - 1067
Published: Oct. 26, 2024
In schizophrenia, it was suggested that an integrated and multimodal approach, combining pharmacological non-pharmacological interventions, could improve functional outcomes clinical features in patients living with schizophrenia (PLWS). Among these alternatives, evidence-based psychosocial interventions (EBPIs) Non-Invasive Brain Stimulation (NIBS) represent feasible treatment options targeting the are unmet needs of PLWS (especially negative cognitive symptoms). As no clear evidence is available on combination approaches, this review aimed to collect literature EBPIs NIBS PLWS. We demonstrated field its infancy, as only 11 studies were reviewed. fact, a few trials, divergent results, combined modalities; while emerging remediation rTMS/iTBS, inconclusive results obtained. Conversely, albeit preliminary, more solid findings HF-rTMS family intervention. Moreover, despite fact activation not be considered EBPI, promising tDCS working memory domain. To overcome limitations, we several methodological issues promote research field.
Language: Английский
Citations
1
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 13, 2024
ABSTRACT Background Substance use disorders (SUDs) and Gambling Disorder (GD) are addictive with a chronic course. Given the limited efficacy of conventional treatments, there is increasing interest in alternative strategies targeting altered neural circuits associated disease. In this context, deep Transcranial Magnetic Stimulation (dTMS) has emerged as novel neuromodulation technique capable reaching brain regions. However, no definite recommendation for its addiction treatment exists. This study systematically reviewed quantitatively analyzed dTMS effects SUDs GD populations. Methods Following PRISMA guidelines, we screened four electronic databases up to February 2024 selected relevant English-written original research articles. 17 papers were included systematic review. As only minority studies employed sham-controlled design, ran meta-analysis on subset 12 studies, computing pre-post real stimulation standardized mean change (SMCC) effect size, using self-reported craving scores dependent variable. Results The results showed significant large active reducing (SMCC = - 1.26, 95% CI [-1.67, 0.86], p <.001). High heterogeneity at both quantitative qualitative levels across was found, focusing different types one gambling behaviors. Conclusions provide initial evidence feasibility care. further comprehensive needed unveil several methodological challenges. limitations available literature future directions critically discussed.
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: March 6, 2023
Abstract The extensive use of transcranial direct current stimulation (tDCS) in experimental and clinical settings does not correspond to an in-depth understanding its underlying neurophysiological mechanisms. In previous studies, we employed integrated system Transcranial Magnetic Stimulation Electroencephalography (TMS-EEG) track the effect tDCS on cortical excitability. At rest, anodal (a-tDCS) over right Posterior Parietal Cortex (rPPC) elicits a widespread increase contrast, cathodal (c-tDCS) fails modulate excitability, being indistinguishable from sham stimulation. Here investigated whether endogenous task-induced activation during might change this pattern, improving c-tDCS effectiveness modulating Study 1, tested performance Visuospatial Working Memory Task (VWMT) modified Posner Cueing (mPCT), involving rPPC, could be modulated by c-tDCS. Thirty-eight participants were involved two-session experiment receiving either or tasks execution. 2, recruited sixteen novel who performed same paradigm but underwent TMS-EEG recordings pre- 10 minutes post-sham Behavioral results showed that significantly mPCT compared sham. level, reduced excitability frontoparietal network task Taken together, our provide evidence state dependence effectively. conceptual applicative implications are discussed.
Language: Английский
Citations
2
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0