The association of adverse family experiences, physical activity, and depression in a national sample of US adolescents DOI
Fanghong Dong

Journal of Child and Adolescent Psychiatric Nursing, Journal Year: 2023, Volume and Issue: 37(1)

Published: Dec. 7, 2023

Abstract Problems Sufficient engagement in physical activity could foster resilience adolescents and help alleviate the impact of adverse family experiences (AFEs), such as depression. However, association between cumulative AFEs exposure, activity, depression remains unclear. The aims this study are to determine relationship adolescent whether moderates relationship. Methods Secondary analyses were conducted on 29,617 aged 12–17 years from 2016–2017 National Survey Children's Health. Binomial logistic regression was used examine among AFEs, child depression, activity. Covariates include individual‐level, social‐level, societal‐level factors. Findings This reveals that 7.3% US had a diagnosis. odds having diagnosis children 1.6 times (adjusted OR: 1.6, 95% CI: 1.37–1.86) greater for with one type 3.4 3.39, 2.78–4.13) three or more compared living without AFEs. Physical 1–3 days per week remained significant, substantial protector childhood at least 0.73, 0.62–0.87). Conclusions These results suggest clinical concern Trauma‐informed care address multiple types trauma interventions reduce symptoms may be particularly important.

Language: Английский

Adverse childhood experiences and lifelong health DOI
Zulfiqar A Bhutta,

Supriya Bhavnani,

Theresa S. Betancourt

et al.

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(7), P. 1639 - 1648

Published: July 1, 2023

Language: Английский

Citations

73
From childhood adversity to latent stress vulnerability in adulthood: the mediating roles of sleep disturbances and HPA axis dysfunction DOI Open Access
Lisa Simon, Roee Admon

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 48(10), P. 1425 - 1435

Published: June 30, 2023

Language: Английский

Citations

27
Allostasis, health, and development in Latin America DOI
Joaquín Migeot, Carolina Panesso, Claudia Durán-Aniotz

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 162, P. 105697 - 105697

Published: May 4, 2024

Language: Английский

Citations

9
Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study DOI Creative Commons
Vanessa Kiyomi Ota,

Adrielle Martins Oliveira,

Amanda Bugiga

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 13, 2025

Introduction While the influence of both genetic and environmental factors on development psychiatric symptoms is well-recognized, precise nature their interaction throughout remains a subject ongoing debate. This study investigated association between expression 78 candidate genes, previously associated with phenotypes, in peripheral blood adversity psychopathology sample 298 young individuals assessed at two time points from Brazilian High Risk Cohort Study for Mental Conditions (BHRCS). Methods Psychopathology was using Child Behavior Checklist (CBCL), considering total CBCL, p-factor (i.e. general factor psychopathology), internalizing externalizing as clinical variables. The life adversities considered this includes four composite variables: child maltreatment, stressful events, threat deprivation. Gene measured next-generation sequencing target genes differential gene analyzed DESeq2 package. Results Mixed models revealed six symptoms: NR3C1, HSPBP1, SIN3A, SMAD4, CRLF3 exhibited negative correlation these symptoms, while FAR1 showed positive correlation. Additionally, we also found USP38 symptoms. Finally, DENND11 PRRC1 were negatively deprivation, latent characterized by neglect, parental absence, measures material forms No mediation or moderation effect observed meaning that they might distinct pathways. Discussion Among nine which encodes glucocorticoid receptor, far most investigated, being depressive early adversity, stress. further research needed to fully understand complex relationship expression, adversities, psychopathology, our findings provide valuable insights into molecular mechanisms underlying mental disorders.

Language: Английский

Citations

1
Treg cell: Critical role of regulatory T-cells in depression DOI Creative Commons
Xiao Gao, Yuru Tang, Lingli Kong

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 195, P. 106893 - 106893

Published: Aug. 21, 2023

Depression is a highly prevalent disorder of the central nervous system. The neuropsychiatric symptoms clinical depression are persistent and include fatigue, anorexia, weight loss, altered sleep patterns, hyperalgesia, melancholia, anxiety, impaired social behaviours. Mounting evidences suggest that neuroinflammation triggers dysregulated cellular immunity increases susceptibility to psychiatric diseases. Neuroimmune responses have transformed approach because their roles in its pathophysiology therapeutic potential. In particular, activated regulatory T (Treg) cells play an increasingly evident role inflammatory immune response. this review, we summarized available data discussed depth fundamental Tregs pathogenesis depression, as well potential Tregs. We aimed provide recent information regarding immune-modulating biologics for treatment prevention long-term depression.

Language: Английский

Citations

19
Adverse childhood experiences and mental health disorder in China: A nationwide study from CHARLS DOI Creative Commons
Ning Ma,

Xiaoxiao Ji,

Yixin Shi

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 355, P. 22 - 30

Published: March 26, 2024

Mental health disorder is highly prevalent worldwide, and factors attributable to its development have not been fully understood. We aimed explore the association of adverse childhood experiences (ACEs) with mental using data from China Health Retirement Longitudinal Study (CHARLS).

Language: Английский

Citations

7
Two identical twin pairs discordant for longstanding anorexia nervosa and OSFED: lived experience accounts of eating disorder and recovery processes DOI Creative Commons
Rosiel Elwyn, Marie Williams,

Eloise Smith

et al.

Journal of Eating Disorders, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 2, 2024

Research into the risk of anorexia nervosa (AN) has examined twin pairs to further understanding contributions genetics, trait inheritance, and environmental factors eating disorder (ED) development. Investigations experiences EDs have been biologically-based not considered qualitative, phenomenological aspects experiences. A gap in literature exists regarding discordant twins with EDs. This research was developed response, aim deepen AN create novel ideas for testing. The case studies presented this article provide lived experience insights two identical pairs: one pair longstanding 'atypical' (the recovered). perspectives each co-twin (one without) explore a number that may contributed discordance these cases, how responded impact their lives. Through use first-person accounts study presentation, centres social justice values leadership involvement research. aims extend current knowledge twins, particularly ED development, duration, diagnosis treatment, recovery processes.

Language: Английский

Citations

3
Molecular insights into trauma: A framework of epigenetic pathways to resilience through intervention DOI
Sarah M. Merrill, Chaini Konwar,

Zaid Fraihat

et al.

Med, Journal Year: 2024, Volume and Issue: unknown, P. 100560 - 100560

Published: Dec. 1, 2024

Language: Английский

Citations

3
Trauma-related disorders and the bodily self: current perspectives and future directions DOI Creative Commons
Daniela Laricchiuta, Carlo Garofalo, Claudia Mazzeschi

et al.

Frontiers in Psychology, Journal Year: 2023, Volume and Issue: 14

Published: May 19, 2023

Trauma-related disorders are debilitating psychiatric conditions that influence people who have directly or indirectly witnessed adversities. Dramatic brain/body transformations and altered person's relationship with self, others, the world occur when experiencing multiple types of traumas. In turn, these unfortunate modifications may contribute to predisposition trauma-related vulnerability conditions, such as externalizing (aggression, delinquency, conduct disorders) problems. This mini-review analyzes relations between traumatic experiences (encoded implicit embodied procedural memories) bodily sense safety for own body, also in presence conducts. Furthermore, an emerging research area is considered, highlighting principles techniques body-oriented sensorimotor therapies designed remodel self-aspects trauma, discussing their potential application individuals showing

Language: Английский

Citations

4
Violence as an obstacle to HIV medication adherence and viral suppression: A daily diary investigation among adolescent boys DOI
Elizabeth M. Inman, Xiaoyue Zhang,

Phumla Madi

et al.

Social Science & Medicine, Journal Year: 2024, Volume and Issue: 364, P. 117549 - 117549

Published: Nov. 22, 2024

Language: Английский

Citations

1