The impact of Subclinical Psychotic Symptoms on Delay and Effort discounting: insights from behavioral, computational, and electrophysiological methods DOI Creative Commons
Damiano Terenzi, Massimo Silvetti,

Giorgia Zoccolan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 26, 2023

Abstract Background The ability to value rewards is crucial for adaptive behavior and influenced by the time effort required obtain them. Impairments in these computations have been observed patients with schizophrenia may be present individuals subclinical psychotic symptoms (PS). Methods In this study, we employed delay effort-discounting tasks food thirty-nine participants divided into high low levels of PS. We investigated underlying mechanisms through computational modelling dopamine prefrontal subcortical circuits electrophysiological biomarker both alterations resting-state frontal alpha asymmetry (FAA). Results revealed greater discounting High PS group compared Low but no differences task. However, task, same estimated release were associated a lower willingness exert high-calorie participants. Although there significant FAA between groups, was significantly severity participants’ negative symptoms. Conclusions Our study suggests that dysfunction temporal cost computations, seen schizophrenia, These findings provide valuable insight early vulnerability markers (behavioral, computational, electrophysiological) psychosis, which aid development preventive interventions.

Language: Английский

Translational Behavioral Neurotoxicology: Essential Considerations for Evaluation and Interpretation of Cognitive Function DOI
Deborah A. Cory‐Slechta,

Margaux C. Masten,

Marissa Sobolewski

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Temporal discounting and self-continuity: Age-dependent patterns and implications DOI
Lu‐lu Liu,

Yongle Lin,

Miao‐Kun Sun

et al.

Acta Psychologica, Journal Year: 2025, Volume and Issue: 255, P. 104970 - 104970

Published: April 7, 2025

Language: Английский

Citations

0
High delay discounting relates to core symptoms and to pulvinar atrophy in frontotemporal dementia DOI Creative Commons
Valérie Godefroy,

Anaïs Durand,

Richard Levy

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

Abstract Behavioural variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder characterized by behavioural changes and atrophy in brain regions important for decision-making. Computations such as trading off between larger later (LL) smaller sooner (SS) rewards — called delay discounting economics might be heavily impaired bvFTD. In this cross-sectional study, our objectives were to investigate (1) whether bvFTD patients show higher than healthy controls, (2) maladaptive correlates with impulsivity-related symptoms, (3) which related bvFTD’s steeper discounting. BvFTD (N=24) matched controls (N=18) performed two tasks: one monetary food rewards. We compared discount rates (log(k)) tested their correlations symptoms. used participants’ structural MRI data applied whole-brain mediation analyses structures mediating the effect of on For both rewards, was significantly controls. patients’ money associated greater disinhibition eating behaviour changes. Whole-brain revealed that several (left thalamic pulvinar, left parahippocampal cortex, right temporal lobe) predictive grey matter density these regions, including most prominently medial mediated The impulsive preference captured constitute common mechanism symptoms inhibition deficit Future studies could further potential role pulvinar modifications transdiagnostic marker therapeutic target impulsivity troubles.

Language: Английский

Citations

3
Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient DOI Creative Commons
Daniel T. Ohm, Emma Rhodes,

Alejandra Bahena

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 11, 2023

Frontotemporal dementia (FTD) is a spectrum of clinically and pathologically heterogenous neurodegenerative dementias. Clinical anatomical variants FTD have been described associated with underlying frontotemporal lobar degeneration (FTLD) pathology, including tauopathies (FTLD-tau) or TDP-43 proteinopathies (FTLD-TDP). patients predominant anterior temporal cortices often develop language disorder semantic knowledge loss and/or social characterized by compulsive rituals belief systems corresponding to left right hemisphere involvement, respectively. The neural substrates these complex disorders remain unclear. Here, we present comparative imaging postmortem study two patients, one FTLD-TDP (subtype C) FTLD-tau Pick disease), who both developed new rigid systems. patient set values centered on positivity specific physical behavioral features pigs, while the compulsive, goal-directed behaviors related general themes spirituality. Neuroimaging showed left-predominant atrophy in right-predominant patient. Consistent antemortem cortical atrophy, histopathologic examinations revealed severe neurons myelin predominantly lobes but more bilateral, dorsolateral involvement featuring greater pathology projection deep white matter. These findings highlight that regions within connected may differential vulnerability distinct FTLD serve important roles human

Language: Английский

Citations

5
The impact of subclinical psychotic symptoms on delay and effort discounting: Insights from behavioral, computational, and electrophysiological methods DOI
Damiano Terenzi, Massimo Silvetti,

Giorgia Zoccolan

et al.

Schizophrenia Research, Journal Year: 2024, Volume and Issue: 271, P. 271 - 280

Published: July 27, 2024

Language: Английский

Citations

0
A structural MRI marker predicts individual differences in impulsivity and classifies patients with behavioral-variant frontotemporal dementia from matched controls DOI Creative Commons
Valérie Godefroy,

Anaïs Durand,

Marie‐Christine Simon

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

ABSTRACT Impulsivity and higher preference for sooner over later rewards (i.e., delay discounting) are transdiagnostic markers of many psychiatric neurodegenerative disorders. Yet, their neurobiological basis is still debated. Here, we aimed at 1) identifying a structural MRI signature discounting in healthy adults, 2) validating it patients with behavioral variant frontotemporal dementia (bvFTD)—a disease characterized by high impulsivity. We used machine-learning algorithm to predict individual differences rates based on whole-brain grey matter density maps male adults (Study 1, N=117). This resulted cross-validated prediction-outcome correlation r =0.35 ( p =0.0028). tested the validity this brain an independent sample 166 its clinical relevance 24 bvFTD 18 matched controls 3). In Study 2, responses did not correlate significantly rates, but both Studies 1 they correlated psychometric measures trait urgency—a measure 3, brain-based predictions separated from 81% accuracy, were associated severity disinhibition among patients. Our results suggest new pattern—the Structural Signature (SIS)—which predicts impulsivity structure, albeit small-to-moderate effect sizes. It provides target that can be future studies assess diagnostic value other conditions

Language: Английский

Citations

0
Single-nucleus RNA sequencing-based construction of a hippocampal neuron atlas in mice with epileptic cognitive impairment DOI Creative Commons

Jia-Qi Ma,

Lu Wang, Yue Zhang

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(10), P. 111065 - 111065

Published: Sept. 28, 2024

Language: Английский

Citations

0
A structural MRI marker predicts individual differences in impulsivity and classifies patients with behavioral-variant frontotemporal dementia from matched controls DOI
Valérie Godefroy,

Anaïs Durand,

Marie‐Christine Simon

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract Impulsivity and higher preference for sooner over later rewards (i.e., delay discounting) are transdiagnostic markers of many psychiatric neurodegenerative disorders. Yet, their neurobiological basis is still debated. Here, we aimed at 1) identifying a structural MRI signature discounting in healthy adults, 2) validating it patients with behavioral variant frontotemporal dementia (bvFTD)—a disease characterized by high impulsivity. We used machine-learning algorithm to predict individual differences rates based on whole-brain grey matter density maps male adults (Study 1, N = 117). This resulted cross-validated prediction-outcome correlation r 0.35 (p 0.0028). tested the validity this brain an independent sample 166 its clinical relevance 24 bvFTD 18 matched controls 3). In Study 2, responses did not correlate significantly rates, but both Studies 1 they correlated psychometric measures trait urgency—a measure 3, brain-based predictions separated from 81% accuracy, were associated severity disinhibition among patients. Our results suggest new pattern—the Structural Signature (SIS)—which predicts impulsivity structure, albeit small-to-moderate effect sizes. It provides target that can be future studies assess diagnostic value other conditions

Language: Английский

Citations

0
The impact of Subclinical Psychotic Symptoms on Delay and Effort discounting: insights from behavioral, computational, and electrophysiological methods DOI Creative Commons
Damiano Terenzi, Massimo Silvetti,

Giorgia Zoccolan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 26, 2023

Abstract Background The ability to value rewards is crucial for adaptive behavior and influenced by the time effort required obtain them. Impairments in these computations have been observed patients with schizophrenia may be present individuals subclinical psychotic symptoms (PS). Methods In this study, we employed delay effort-discounting tasks food thirty-nine participants divided into high low levels of PS. We investigated underlying mechanisms through computational modelling dopamine prefrontal subcortical circuits electrophysiological biomarker both alterations resting-state frontal alpha asymmetry (FAA). Results revealed greater discounting High PS group compared Low but no differences task. However, task, same estimated release were associated a lower willingness exert high-calorie participants. Although there significant FAA between groups, was significantly severity participants’ negative symptoms. Conclusions Our study suggests that dysfunction temporal cost computations, seen schizophrenia, These findings provide valuable insight early vulnerability markers (behavioral, computational, electrophysiological) psychosis, which aid development preventive interventions.

Language: Английский

Citations

0