Multi-Epigenome-Wide Analyses and Meta-Analysis of Child Maltreatment in Judicial Autopsies and Intervened Children and Adolescents DOI Creative Commons
Akemi Tomoda, Shota Nishitani, Takashi X. Fujisawa

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 15, 2023

Abstract Child maltreatment (CM) leads to adverse outcomes in later life. We describe the epigenome-wide analyses and meta-analysis results of three original cohorts consisting judicially or socially certified CM cases controls gain further insight into epigenetic signatures engraved maltreated children. also show associations with biological indicators (endophenotypes) each cohort that represent features history, thus providing confidence identified methylations. Four methylations ATE1 , CHST11 SERPINB9P1 FOXP1 associate meta-analysis, addition several genome-wide level significant cohort. a gene related neurodevelopmental disorders, is particular interest, as its methylation correlates atypical brain structures representing children contributes accuracy risk score predict CM. These suggest severe experiences may contribute neurodevelopmental-like traumatic symptoms via alterations.

Language: Английский

Intergenerational transmission of complex traits and the offspring methylome DOI Creative Commons
Fiona A. Hagenbeek, René Pool, Austin J. Van Asselt

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 16, 2024

Abstract The genetic makeup of parents can directly or indirectly affect their offspring phenome through transmission via the environment that is influenced by parental heritable traits. Our understanding mechanisms which indirect effects operate limited. Here, we hypothesize one mechanism methylome. To test this hypothesis, polygenic scores (PGSs) for schizophrenia, smoking initiation, educational attainment (EA), social deprivation, body mass index (BMI), and height were analyzed in a cohort 1,528 (51.5% boys, mean [ SD ] age = 10 [2.8] years). We modelled parent PGSs on buccal-DNA methylation, accounting own PGS offspring, found significant associations between EA, BMI, height, buccal methylation sites, comprising 16, 2, 1, 6 respectively (alpha 2.7 × −5 ). More DNA sites associated with maternal than paternal PGSs, possibly reflecting pre- periconceptional stronger involvement shaping offspring’s during early childhood.

Language: Английский

Citations

0
Am Ende der Gewalt begannen die Schmerzen DOI
Philipp Wülfing, Carsten Spitzer

Trauma und Gewalt, Journal Year: 2024, Volume and Issue: 18(2), P. 170 - 175

Published: April 23, 2024

Frühe biografische Traumatisierungen in Form von Missbrauch und Vernachlässigung stellen allgemeine Risikofaktoren für eine große Bandbreite psychopathologischer Phänomene psychischer Störungen dar. In der klinischen Praxis gibt es immer wieder Einzelfälle mit einer hohen intraindividuellen Variabilität Psychopathologie über die Lebensspanne. Mit hier präsentierten Krankengeschichte eines Anfang 50-jährigen Mannes wird illustriert, dass schwerer körperlicher Missbrauch, den Patient bis zu seinem 16. Lebensjahr durch seinen Stiefvater erlitten hat, Aggressivität bzw. Delinquenz, Substanzabhängigkeit, einem ängstlich-depressiven Syndrom chronischen Schmerzen assoziiert sein kann.

Citations

0
Mediating effects of DNA methylation levels (cg04622888 and cg05037505) on the association between childhood maltreatment and non-suicidal self-injury in adolescents DOI
Yanqi Li,

Shaungshuang Guo,

Xinyi Xie

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract Aims It is unclear whether DNA methylation underlies the associations of childhood maltreatment (CM) with non-suicidal self-injury (NSSI) in adolescents. We aim to explore mediating effect specific sites’ levels on CM and its subtypes NSSI, following investigation association between NSSI. Methods A nested case-control study was conducted examine 155 adolescents aged 12–14 years who had NSSI 201 controls. were evaluated using Childhood Trauma Questionnaire. The 850k chip used discover differences whole genome peripheral blood 10 cases Pyrosequencing employed detect differential sites among population, which selected based bioinformatics analysis. Results After controlling for potential confounders, subtypes, cg04622888 cg05037505 all significantly associated level mediated emotional abuse (proportion estimates: 0.09; 95% CI: 0.06–0.14), neglect (0.08; 95%CI: 0.05–0.13), or physical (0.18; 0.08–0.31) (0.14; 0.06–0.25) Conclusions independently early adolescents, they partially abuse, neglect, Targeted interventions should focus individuals have experienced exhibit high cg05037505.

Language: Английский

Citations

0
Asma e interação gene-ambiente: estamos no caminho certo em nossa prática clínica? DOI Creative Commons
Karla Danielle Xavier do Bomfim

Revista Brasileira de Saúde Materno Infantil, Journal Year: 2024, Volume and Issue: 24

Published: Jan. 1, 2024

Citations

0
Asthma and gene-environment interaction: are we on the right path in our clinical practice? DOI Creative Commons
Karla Danielle Xavier do Bomfim

Revista Brasileira de Saúde Materno Infantil, Journal Year: 2024, Volume and Issue: 24

Published: Jan. 1, 2024

Language: Английский

Citations

0
Neuroendocrine Effects on the Risk of Metabolic Syndrome in Children DOI Open Access
Giovanna Scorrano, Saverio La Bella, Sara Matricardi

et al.

Published: May 30, 2023

Endocrine and nervous systems reciprocally interact to manage physiological individual functions homeostasis. The system modulates hormone release through the hypothalamus, main cerebrally specialized structure of neuroendocrine system. Indeed, it is involved in various metabolic processes, administering neuropeptide at different levels. This complex activity affected by neurons cerebral areas, environmental factors, peripheral organs, mediators feedback mechanisms. Therefore, pathways have a key role homeostasis control, their abnormalities been associated with development Metabolic Syndrome (MetS) children. impaired functioning genes, hormones, neuropeptides several processes has related an increased risk dyslipidaemia, visceral obesity, insulin resistance, type 2 diabetes mellitus, hypertension. review examines effects on MetS children, identifying underlying conditions pathway disruption. Neuroendocrine should be considered pathophysiology MetS, and, when genetic or epigenetic mutations "hot" occur, they could studied for new potential target therapies severe drug-resistant paediatric forms MetS.

Language: Английский

Citations

1
Gene–environment interaction: why genetic enhancement might never be distributed fairly DOI
Sinead Prince

Journal of Medical Ethics, Journal Year: 2023, Volume and Issue: 50(4), P. 272 - 277

Published: June 2, 2023

Ethical debates around genetic enhancement tend to include an argument that the technology will eventually be fairly accessible once available. That we can distribute has become a moral defence of enhancement. Two distribution solutions are argued for, first being equal distribution. Equality access is generally believed fairest and most just method Second, equitable distribution: providing enhancements reduce social inequalities. In this paper, I make two claims. argue very assumption distributed problematic when considering our understanding gene-environment interactions, for example, epigenetics. then arguments permissible because intended benefits as misinformed. My claim rests on assertion do not enhance traits in vacuum; genes dependent conducive environments expression. If society cannot guarantee fair environments, any benefit conferred from genetically enhanced undermined. Thus, therefore morally permissible, mistaken.

Language: Английский

Citations

1
Neuroendocrine Effects on the Risk of Metabolic Syndrome in Children DOI Creative Commons
Giovanna Scorrano, Saverio La Bella, Sara Matricardi

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(7), P. 810 - 810

Published: June 29, 2023

The endocrine and nervous systems reciprocally interact to manage physiological individual functions homeostasis. system modulates hormone release through the hypothalamus, main cerebrally specialized structure of neuroendocrine system. hypothalamus is involved in various metabolic processes, administering neuropeptide at different levels. This complex activity affected by neurons cerebral areas, environmental factors, peripheral organs, mediators feedback mechanisms. Therefore, pathways play a key role homeostasis control, their abnormalities are associated with development syndrome (MetS) children. impaired functioning genes, hormones, neuropeptides several processes related an increased risk dyslipidaemia, visceral obesity, insulin resistance, type 2 diabetes mellitus, hypertension. review examines effects on MetS children, identifying underlying conditions pathway disruption. Neuroendocrine should be considered pathophysiology MetS, and, when genetic or epigenetic mutations “hot” occur, they could studied for new potential target therapies severe drug-resistant paediatric forms MetS.

Language: Английский

Citations

1
Multi-Epigenome-Wide Analyses and Meta-Analysis of Child Maltreatment in Judicial Autopsies and Intervened Children and Adolescents DOI Creative Commons
Akemi Tomoda, Shota Nishitani, Takashi X. Fujisawa

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 15, 2023

Abstract Child maltreatment (CM) leads to adverse outcomes in later life. We describe the epigenome-wide analyses and meta-analysis results of three original cohorts consisting judicially or socially certified CM cases controls gain further insight into epigenetic signatures engraved maltreated children. also show associations with biological indicators (endophenotypes) each cohort that represent features history, thus providing confidence identified methylations. Four methylations ATE1 , CHST11 SERPINB9P1 FOXP1 associate meta-analysis, addition several genome-wide level significant cohort. a gene related neurodevelopmental disorders, is particular interest, as its methylation correlates atypical brain structures representing children contributes accuracy risk score predict CM. These suggest severe experiences may contribute neurodevelopmental-like traumatic symptoms via alterations.

Language: Английский

Citations

0