Freezing of gait in Chinese patients with multiple system atrophy: prevalence and risk factors DOI Creative Commons
Yalan Chen, Hui Wang,

Hongyan Huang

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: June 7, 2023

Freezing of gait (FOG) is common in neurodegenerative forms atypical parkinsonism, but few studies have examined FOG multiple system atrophy (MSA). In this study, we the prevalence freezing and its relationship to clinical features a large cohort Chinese MSA patients.This exploratory study included 202 patients with probable MSA. was defined as score ≥ 1 on item 14 Unified Parkinson's Disease Rating Scale. Patients or without were compared terms Scale (UMSARS) well cognitive neuropsychiatric assessments.The frequency 48.0, 52.1, 38.7% MSA, predominant parkinsonism (MSA-P), cerebellar ataxia (MSA-C), respectively. associated worse subscores parts I, II IV UMSARS total score; greater likelihood speech difficulties, falls, impairment balance disorder; more severe symptoms anxiety depression; lower activities daily living. The binary logistic regression model indicated that higher scores MSA-P, MSA-C patients.Freezing may be among patients, correlate motor symptoms, anxiety, depression Total an independent risk factor for FOG.

Language: Английский

Effects of activity-oriented physiotherapy with and without eye movement training on dynamic balance, functional mobility, and eye movements in patients with Parkinson’s disease: An assessor-blinded randomised controlled pilot trial DOI Creative Commons
Sarah Mildner, Isabella Hotz,

Franziska Kübler

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(6), P. e0304788 - e0304788

Published: June 14, 2024

Objectives To describe changes in balance, walking speed, functional mobility, and eye movements following an activity-oriented physiotherapy (AOPT) or its combination with movement training (AOPT-E) patients Parkinson’s disease (PD). explore the feasibility of a full-scale randomised controlled trial (RCT). Methods Using assessor-blinded pilot RCT, 25 PD were allocated to either AOPT AOPT-E. Supervised interventions performed 30 minutes, 4x/weekly, for 4 weeks, alongside inpatient rehabilitation. Outcomes assessed at baseline post-intervention, including dynamic dual-task ability safely health-related quality life (HRQoL), depression, (number/duration fixations) using mobile tracker. Freezing gait (FOG), falls-related self-efficacy baseline, 4-week follow-up. Effect sizes 0.10 considered weak, 0.30 moderate, ≥0.50 strong. Feasibility was predefined criteria: recruitment, retention adherence rates, adverse events, falls, post-intervention acceptability qualitative interviews. Results Improvements observed balance (effect size r = 0.216–0.427), speed (r 0.165), mobility 0.306–0.413), 0.247), HRQoL 0.024–0.650), depression 0.403). Falls-related 0.621) FOG 0.248) showed varied improvements, partly sustained Eye improvements after AOPT-E only. analysis revealed that recruitment below target, less than two recruited per month due COVID-19 restrictions. targets met, rate 96% (95% confidence interval [CI]: 77.68–99.79) 98.18% CI: 96.12–99.20) rate, exceeding 80% 75%, respectively. One event unrelated study intervention confirmed safety, interview data indicated high acceptability. Conclusions appeared be effective PD. larger RCT is needed validate results.

Language: Английский

Citations

3
Augmented reality cueing for freezing of gait: Reviewing an emerging therapy DOI Open Access
Brendan Baugher, Nathaniel J. Szewczyk, James Liao

et al.

Parkinsonism & Related Disorders, Journal Year: 2023, Volume and Issue: 116, P. 105834 - 105834

Published: Sept. 7, 2023

Language: Английский

Citations

7
Engaging multi-stakeholders to develop a great digital assistive technology that Parkinson's disease patients love, value, and use to improve motor aspects of daily living DOI
Roongroj Bhidayasiri,

Tittaya Prasertpan,

Michèle Tinazzi

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 233 - 255

Published: Jan. 1, 2024

Language: Английский

Citations

2
Spatiotemporal, kinematic and kinetic gait characteristics in Parkinson's disease compared to healthy individuals: A systematic review with meta-analysis DOI
Daniele Bonacina,

Diego Tosatto,

Alessandro Ugolini

et al.

Clinical Biomechanics, Journal Year: 2024, Volume and Issue: 120, P. 106359 - 106359

Published: Oct. 9, 2024

Language: Английский

Citations

2
Specialized Allied Health Care for Parkinson’s Disease: State of the Art and Future Directions DOI Creative Commons

Ingrid H.W.M. Sturkenboom,

Amir H. Talebi, Bart R. Maas

et al.

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(s1), P. S193 - S207

Published: July 19, 2024

People with Parkinson's disease (PD) experience a range of progressive motor and non-motor symptoms, that negatively affect their daily functioning, social participation quality life. Allied health therapies have emerged as an effective treatment approach-complementary to pharmacological neurosurgical treatments-which reduces the impact PD in In this article, we propose criteria for what constitutes specialized allied care PD, review research terms meeting these its outcomes monodisciplinary approaches well multi- or interdisciplinary interventions. We focus on three most studied disciplines PD: physical therapy, occupational therapy speech-language therapy. Overall, available evidence underscores importance potential benefits people PD. Our proposed recommendations future might help further delineating care.

Language: Английский

Citations

1
Efficacy of exercise interventions combined with Selegiline in ameliorating freezing of gait in Parkinson’s disease patients DOI

Yueying Fang,

Jian Wang,

Dongliang Nie

et al.

American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(7), P. 2852 - 2863

Published: Jan. 1, 2024

To evaluate the efficacy of exercise interventions combined with Selegiline in ameliorating freezing gait (FOG) Parkinson's disease (PD) patients.

Language: Английский

Citations

0
Impacto da utilização de pistas auditivas, visuais e táteis na dupla tarefa na Doença de Parkinson- uma revisão sistemática DOI Creative Commons
Marlene Rosa,

André Pedrosa,

Beatriz Magalhães

et al.

Retos, Journal Year: 2024, Volume and Issue: 59, P. 172 - 186

Published: July 26, 2024

Objetivo: Caracterizar, através de uma revisão sistemática, a influência diferentes tipologias pistas (auditiva, visual, tátil) no desempenho da dupla-tarefa na Doença Parkinson. Metodologia: A pesquisa primária foi realizada nas bases dados PubMed, Scopus e Science Direct. Os estudos foram incluídos acordo com os critérios elegibilidade: (i) artigos publicados em revistas/jornais científicos; (ii) nos últimos 10 anos; (iii) escritos língua portuguesa, espanhola inglesa; (iv) inclusão participantes doença Parkinson, mesmo que grupos mistos, mas específicos dupla tarefa; (v) descrição intervenção tarefa. Resultados: 13 nesta sistemática: 5 boa qualidade, 7 qualidade razoável, um pobre. Verifica-se maior utilização visuais, 6 estudos; 3 auditivas; 2 táteis audiovisuais. Relativamente à tarefa: 8 realizaram tarefa cognitiva, motora efetuaram ambas. Apenas usaram medidas correlação entre o presente demonstra as (visuais motoras) melhoram características espaciotemporais marcha Parkinson tarefa, por outro lado, representa exigência planeamento do movimento. Conclusão: Esta sistemática identificou significativa variabilidade metodologias usadas. As visuais destacam-se pela sua mais frequente De forma geral, parece aumentar nestes pacientes. Palavras-chave: Neuromuscular; Reabilitação; Terapia pelo Exercício; Retorno; Sensorial

Citations

0
Lower-Limb Exoskeletons for Gait Training in Parkinson’s Disease: The State of the Art and Future Perspectives DOI Open Access
Matteo Fortunati, Massimiliano Febbi, Massimo Negro

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(16), P. 1636 - 1636

Published: Aug. 16, 2024

Gait dysfunction (GD) is a common impairment of Parkinson's disease (PD), which negatively impacts patients' quality life. Among the most recent rehabilitation technologies, lower-limb powered exoskeleton (LLEXO) arises as useful instrument for gait training in several neurological conditions, including PD. However, some questions relating to methods use, achievable results, and usefulness compared traditional methodologies still require clear answers. Therefore, this review, we aim summarise analyse all studies that have applied an LLEXO train PD patients. Literature research on PubMed Scopus retrieved five articles, comprising 46 participants stable medications (age: 71.7 ± 3.7 years, 24 males, Hoehn Yahr: 2.1 0.6). Compared rehabilitation, low-profile (lp-LLEXO) brought major improvements towards walking capacity speed, while there are no benefits regarding dual-task cost index freezing symptoms. Importantly, results suggest lp-LLEXO more beneficial patients with intermediate-to-severe level severity (Hoehn Yahr > 2.5). This review could provide novel framework implementing clinical practise, highlighting its limitations training.

Language: Английский

Citations

0
A Pilot Interventional Study on Feasibility and Effectiveness of the CUE1 device in Parkinson's disease. DOI Open Access
Viktoria Azoidou,

Kira Rowsell,

Ellen Camboe

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 11, 2024

SCIENTIFIC ABSTRACT Introduction Current treatments for patients with Parkinson’s disease (PwP) can fail to address gait disturbance and falls, which in turn affect quality of life (QoL). The CUE1 device delivers cueing vibrotactile stimulation showing potential alleviate motor symptoms reduce falls based on preliminary user testing results. Objectives To evaluate the feasibility, safety, tolerability its effect non-motor PwP. Methods PwP used 9-weeks were assessed at week 0, 3, 6, 9 MDS-UPDRS Part-III, Timed Up Go (TUG), TUG dual task (DT), Functional Gait Assessment (FGA), Bradykinesia Akinesia Incoordination (BRAIN) test. Patients reported outcomes through Part-I, -II, -IV Pittsburgh Sleep Quality Index (PSQI). Results Ten (5 females, age range: 46-80; duration: 3-9 years) completed intervention 100% compliance no adverse events. comfort usability rated highly (80%). Immediate was observed MDS-UPDRS- III(45.40±12.22 vs 39.60±11.74, p=0.008), TUG(11.53±1.92 11.08±1.94, p=0.022), DT(18.57±5.75 17.61±6.28, p=0.037) FGA(16.40±3.86 18.60±3.92, p=0.007). Cumulative noted MDS-UPDRS-III(45.40±12.22 27.80±12.32, p=0.005), FGA(18.60±3.92 23.10± 2.85, p<0.001), 13.58±7.05, p=0.031), BRAIN kinesia (45.10±14.39 42.10±12.74, p<0.001) incoordination (24331.09±38017.46 14059.91± 9030.96, p=0.016) scores, PSQI(10.10±4.95 6.90±3.81, p=0.002), MDS-UPDRS-I(18.60±6.75 12.20±3.68, p=0.011), II(17.30±7.29 11.90±8.67, MDS-UPDRS-IV(7.50±3.75 3.40±2.95, p=0.003). Conclusion In this unblinded, feasibility study, appeared be a feasible safe improving features. PLAIN Background This study looked use called CUE1, provides rhythmic pulsing vibration help movement non-movement people (PwP). Even current treatments, issues walking falling still many patients. goal see if could helpful, safe, easy-to-use tool symptoms, like risk falling, as well sleep. Procedures women, aged 46-80) who had years weeks. Everyone finished using regularly negative side effects. 80% ease use. Significant improvements seen abilities (using MDS-UPDRS-III test), speed, fall risk. Over weeks, participants showed further progress movement, balance, coordination. Non-movement sleep, also improved. Conclusions device, gentle vibrations assist found easy use, effective. It improved both movement-related balance walking, makes it promising new treatment option Parkinson’s.

Language: Английский

Citations

0
The effect of tactile cueing on dual task performance in Parkinson’s disease. A systematic review and meta-analysis DOI Creative Commons
Viktoria Azoidou, Alastair Noyce, Cristina Simonet

et al.

Clinical Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 11, P. 100284 - 100284

Published: Jan. 1, 2024

Dual-task (DT) performance is impaired in Parkinson's disease (PD), contributing to bradykinesia, postural instability, freezing of gait, and falls. Tactile cueing, including vibrotactile stimulation, has been suggested improve DT PD.

Language: Английский

Citations

0