Introducing Braining—physical exercise as adjunctive therapy in psychiatric care: a retrospective cohort study of a new method DOI Creative Commons

Åsa Anger,

Anna Wallerblad,

Leida Kaaman

et al.

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: Aug. 7, 2023

Abstract Background Patients with severe mental disorders suffer from higher rates of poor somatic health and have shorter life expectancy than the average population. Physical activity can treat prevent several diseases, e.g. cardiovascular metabolic as well psychiatric symptoms. It is therefore utmost importance to develop effective methods integrate physical into care. To meet this need, intervention Braining was developed. This study aims describe Braining, assess number patients reached during first years pilot testing, analyze clinical data in group participating 2017–2020 intervention. Methods In descriptive retrospective we analyzed all training sessions ≥ 3 times ( n = 239), Participants. Regular at clinic served a comparison. Furthermore, medical records were studied for smaller cohort 51), Pilot Cohort. Data using Chi-square Fisher’s tests. Results During introduction period 580 attended an information meeting about or least one session. 239 participated sessions, considered be participants Braining. These Participants ages 19 82, males 23.4%, between 308 (median 9). The main diagnoses affective anxiety disorders. Number ranged 0 10 2). For subsample, Cohort 208 20). Twelve percent working full-time, symptom severity depression general moderate. Two thirds had different classes medication. Regarding morbidity, 28% been diagnosed hypertension, though blood lipids, glucose pressure within normal range. Thirty-seven prescribed Activity on Prescription 2017–2020. One adverse event reported. Conclusions age-groups wide representative diagnostic panorama, suggesting that could promising safe method implementing patient

Language: Английский

Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity DOI Creative Commons
Pau Soldevila-Matías, Joan Vicent Sánchez‐Ortí, Patricia Correa‐Ghisays

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0313759 - e0313759

Published: Jan. 3, 2025

Introduction This study aimed to evaluate the predictive validity and discriminatory ability of clinical outcomes, inflammatory activity, oxidative vascular damage, metabolic mechanisms for detecting significant improve maximum heart rate after physical activity training in individuals with psychiatric disorders obesity comorbid using a longitudinal design transdiagnostic perspective. Methods Patients major depressive disorder, bipolar disorder and, schizophrenia (n = 29) were assigned 12-week structured exercise program. Peripheral blood biomarkers inflammation, stress, mechanisms, as well neurocognitive functional performance assessed twice, before intervention. Maximum was considered marker effectiveness activity. Mixed one-way analysis variance linear regression analyses performed. Results Individuals exhibited an improvement cognition, mood symptoms body mass index, increase anti-inflammatory together enhancement cardiovascular (p<0.05 0.0001; d 0.47 1.63). A better outcomes along regulation inflammatory, oxidative, critical predicting variation over time (χ 2 32.2 39.0, p < 0.0001). Conclusions The may be essential maintained healthy across obesity. Likewise, cardio-metabolic useful identify at greater risk multi-comorbidity.

Language: Английский

Citations

0
Association between lifestyle behaviors and depression in 90.814 Brazilian adults: A cluster analysis DOI

Sarah Vitória Bristot Carnevalli,

Renato Cláudino,

Luís Almeida

et al.

Mental health and physical activity, Journal Year: 2025, Volume and Issue: unknown, P. 100672 - 100672

Published: Jan. 1, 2025

Language: Английский

Citations

0
A Unified Pathogenic Hypothesis for Mental Disorders Based on Schismogenesis DOI Creative Commons
Mauro García‐Toro, Rocío Gómez-Juanes

Biosystems, Journal Year: 2025, Volume and Issue: unknown, P. 105431 - 105431

Published: Feb. 1, 2025

Language: Английский

Citations

0
Bipolar disorder: Diagnosis, treatment and future directions DOI
Natalie M Lane, Daniel J. Smıth

The Journal of the Royal College of Physicians of Edinburgh, Journal Year: 2023, Volume and Issue: 53(3), P. 192 - 196

Published: Aug. 30, 2023

Bipolar disorder is a relatively common mental illness, characterised by recurrent episodes of mania (or hypomania) and major depression, associated with significant burden morbidity premature mortality. Physicians across all specialities are likely to encounter individuals the condition within their clinical practice. This short review provides an up-to-date overview features, epidemiology, pathophysiology, evidence-based management, prognosis future directions for treatment research in bipolar disorder. Aspects cross-specialty relevance highlighted, including physical health condition, side effects safety considerations medication regimes used

Language: Английский

Citations

9
EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence DOI Creative Commons
Isabel Maurus, Sarah Wagner, Johanna Spaeth

et al.

European Psychiatry, Journal Year: 2024, Volume and Issue: 67(1)

Published: Jan. 1, 2024

Abstract There is growing interest in lifestyle interventions as stand-alone and add-on therapies mental health care due to their potential benefits for both physical outcomes. We evaluated focusing on activity, diet, sleep adults with severe illness (SMI) the evidence effectiveness. To this end, we conducted a meta-review searched major electronic databases articles published prior 09/2022 updated our search 03/2024. identified 89 relevant systematic reviews assessed quality using SIGN checklist. Based findings of clinical expertise authors, formulated seven recommendations. In brief, supports application that combine behavioural change techniques, dietary modification, activity reduce weight improve cardiovascular parameters SMI. Furthermore, should be used an adjunct treatment SMI, including psychotic symptoms cognition schizophrenia or depressive depression. ameliorate quality, cognitive informed can considered. Additionally, provide overview key gaps current literature. Future studies integrate outcomes reflect multi-faceted interventions. Moreover, highlighted relative dearth relating bipolar disorder nutritional research could help establish core component care.

Language: Английский

Citations

1
The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls DOI Open Access

Bernadette Leser,

Nina Dalkner, Adelina Tmava‐Berisha

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4111 - 4111

Published: Sept. 22, 2023

Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, link cognitive ability with bipolar disorder has not been studied yet. Thus, we aimed to investigate 25-hydroxyvitamin (25(OH)D), 24,25 dihydroxyvitamin (24,25(OH)2D, metabolite ratio (VMR) a cohort of euthymic patients disorder. Vitamin metabolites were measured simultaneously by liquid-chromatography tandem mass-spectrometry serum samples from 86 outpatients 93 controls. Neither inactive precursor 25(OH)D, nor primary catabolite 24,25(OH)2D, or significantly associated domains “attention”, “memory”, “executive function” Further, no deficiency effect interaction group × was found domain scores. In summary, present study does support metabolism as modulating factor function BD patients. Considering current study’s cross-sectional design, future research should expand these results longitudinal setting include additional aspects mental health, such manic depressive symptoms, long-term illness course psychopharmacological treatment.

Language: Английский

Citations

3
Vitamin D Status in Bipolar Disorder DOI Open Access

Zita Späth,

Adelina Tmava‐Berisha, Frederike T. Fellendorf

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(22), P. 4752 - 4752

Published: Nov. 11, 2023

Vitamin D status may impact acute affective symptomatology and the severity of symptoms in patients with bipolar disorder (BD). Therefore, this cross-sectional study analyzed 25(OH)D, 24,25(OH)2D, vitamin metabolite ratio (VMR) BD correlated results clinical functionality. The inactive precursor its principal catabolite were measured simultaneously a validated liquid chromatography–tandem mass spectrometry method 170 outpatients 138 healthy controls. VMR was calculated as follows: = 100×(24,25(OH)2D/25(OH)D). psychometric assessment comprised: Beck Depression Inventory-II, Hamilton Rating Scale, Young Mania Global Assessment Functioning, number suicide attempts. We did not find significant difference between controls concentrations 25(OH)D 24,25(OH)2D. Additionally, comparable both groups. calculations for parameters showed negative correlation Scale 24,25(OH)2D (r −0.154, p 0.040), well −0.238, 0.015). Based on small effect size predominantly euthymic sample, further exploration individuals manic would be needed to confirm association. In addition, long-term markers an different phases disease provide additional insights.

Language: Английский

Citations

3
Gene expression insights: Chronic stress and bipolar disorder: A bioinformatics investigation DOI Creative Commons

Rongyanqi Wang,

Lan Li, Man Chen

et al.

Mathematical Biosciences & Engineering, Journal Year: 2023, Volume and Issue: 21(1), P. 392 - 414

Published: Jan. 1, 2023

<abstract><p>Bipolar disorder (BD) is a psychiatric that affects an increasing number of people worldwide. The mechanisms BD are unclear, but some studies have suggested it may be related to genetic factors with high heritability. Moreover, research has shown chronic stress can contribute the development major illnesses. In this paper, we used bioinformatics methods analyze possible affecting through various aspects. We obtained gene expression data from postmortem brains patients and healthy controls in datasets GSE12649 GSE53987, identified 11 stress-related genes (CSRGs) were differentially expressed BD. Then, screened five biomarkers (IGFBP6, ALOX5AP, MAOA, AIF1 TRPM3) using machine learning models. further validated diagnostic value other (GSE5388 GSE78936) performed functional enrichment analysis, regulatory network analysis drug prediction based on biomarkers. Our revealed affect occurrence many aspects, including monoamine oxidase production decomposition, neuroinflammation, ion permeability, pain perception others. confirm importance studying influences disorders potential tools therapeutic targets for BD.</p></abstract>

Language: Английский

Citations

2
Use of a virtual environment to promote self-management and lifestyle changes in persons with bipolar disorder DOI
Rebecca L. Casarez, Constance Johnson, Jair C. Soares

et al.

Archives of Psychiatric Nursing, Journal Year: 2024, Volume and Issue: 49, P. 73 - 82

Published: Feb. 12, 2024

Language: Английский

Citations

0
Experiences of self-recovery among adults with bipolar disorder: a narrative review DOI

Emilie Carey-Hock

Mental Health Practice, Journal Year: 2024, Volume and Issue: 27(4), P. 22 - 27

Published: April 9, 2024

Bipolar disorder is a potentially lifelong and disabling condition characterised by episodes of mania or hypomania depressed mood. In recent decades the focus management has shifted towards supporting patients self-recovery. The author this article conducted narrative review qualitative literature to explore experiences self-recovery among adult with bipolar disorder. Six themes emerged from thematic synthesis – relapse prevention, acceptance, social professional support, lifestyle, psychological therapy psychoeducation. Understanding psychosocial factors that influence recovery in can guide recovery-oriented interventions, leading enhanced well-being quality life for patients.

Language: Английский

Citations

0