The interface of depression and diabetes: treatment considerations

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 24, 2025

This state-of-the-art review explores the relationship between depression and diabetes, highlighting two-way influences that make treatment challenging worsen outcomes of both conditions. Depression diabetes often co-occur share genetic, lifestyle, psychosocial risk factors. Lifestyle elements such as diet, physical activity, sleep patterns play a role on development management conditions, need for integrated strategies. The evidence suggests traditional strategies focusing either condition in isolation fall short addressing intertwined nature depression. Instead, care models encompassing psychological support medical are recommended to improve efficacy patient adherence. Such require collaboration across multiple healthcare disciplines, including endocrinology, psychiatry, primary care, offer holistic approach care. also identifies significant patient-related barriers effective management, stigma, resistance, health literacy, which be addressed through patient-centered education systems. Future directions research include longitudinal studies diverse populations further elucidate causal relationships exploration novel therapeutic targets, well effectiveness aimed at preventing onset one individuals diagnosed with other.

Language: Английский

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The Patient’s Perspective on the Effects of Intranasal Esketamine in Treatment-Resistant Depression

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(10), P. 1494 - 1494

Published: Oct. 22, 2023

The effectiveness of the esketamine nasal spray (ESK-NS) for treatment-resistant depression (TRD) has been confirmed by real-world studies. Available evidence derived from clinician-rated assessments might differ patients' perceptions about helpfulness treatments. We aimed to verify effect ESK-NS view in 25 TRD patients (56% males, 55.1 ± 10.9 years) treated with (mean dose: 78.4 11.43 mg) three months and evaluated at different time-points through self-administered scales, assessing changes depression, anhedonia, sleep, cognition, suicidality, anxiety. observed an overall early improvement that lasted over time (endpoint total score reduction Montgomery-Åsberg Depression Rating Scale, p < 0.001, Beck Inventory, = 0.003). Patients reported a significant self-rated decrease anhedonia two (Snaith-Hamilton Pleasure 0.04) suicide ideation endpoint (BDI subitem 9, 0.039) vs. earlier improvements detected clinicians (one-month MADRS 8, 0.005, 10, 0.007). These findings confirm three-month treatment patients, highlighting overlapping response clinicians' perspectives, although some differential effects on specific symptoms given time-points. Including viewpoints routine could inform clinical practice, ensuring better characterization phenotypes deliver personalized interventions.

Language: Английский

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Translational models of stress and resilience: An applied neuroscience methodology review

Neuroscience Applied, Journal Year: 2024, Volume and Issue: 3, P. 104064 - 104064

Published: Jan. 1, 2024

Stress, encompassing psychological, physical, and physiological challenges, is an important factor affecting individual's well-being potentially leading to psychiatric, neurodegenerative, immune, metabolic disorders. However, not everyone exposed stress develops these conditions, highlighting the concept of resilience. Resilience a dynamic process categorized into four dimensions: pre-existing resilience capacity, ongoing processes, post-stress outcomes, recovery from psychopathologies. These dimensions involve genomic, cellular, systemic interactions influenced by genetic factors, early life experiences, adult experiences in addition community/environmental health behaviors. The biological response encompasses endocrine, autonomic, immunological, behavioral components, modulated stressor characteristics individual traits. Due limitations studying humans, translational models using rodents cell cultures are essential. Rodent include acute, chronic, traumatic paradigms, aiding study stress-related molecular outcomes. Additionally, models, such as prenatal maternal separation, provide insights developmental impacts. In this review, first, rodent for lifelong exposure will be summarized considering their validity, advantages, limitations. Subsequently, overview designed enhance capacity rodents, later employed outcomes given. Lastly, focus shifted culture iPSCs models. Finally, future considerations focused on improving used discussed. It aimed designs access more effective biomarkers associated with Stress complex phenomena various spanning levels. Integrating data across remains crucial unraveling complexities disorders

Language: Английский

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Prevalence of anhedonia in women with deep endometriosis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 4, 2025

Anhedonia, characterized by diminished motivation and pleasure sensitivity, is increasingly recognized as prevalent among patients with chronic pain. Deep Endometriosis (DE), the most severe endophenotype of disease, commonly presented pelvic This cross-sectional study reports, for first time, prevalence anhedonia in a sample comprised 212 premenopausal women suspected DE referred to tertiary hospital. Our findings show that 27,8% [95% CI 22.1, 26.5] experience abnormal hedonic tone. Severity pain-related symptoms significantly correlated anhedonia, consistent previous findings. Chronic pain emerged significant predictor (OR 1.5, 95% 1.0–1.22, p < 0.05) odds increasing 2.28 1.12, 4.23] when was severe. The affected areas were interests, social interaction food pleasure. present results are representative under multimodal treatment, limiting generalizability. Overall, our highlights impact on functioning DE. Therapeutic approaches targeting capacity crucial restoring health well-being.

Language: Английский

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Perinatal Protein Restriction Induces Anhedonic‐Like Behavior: Disturbed Hippocampal Neurotrophic Signaling and Neuronal Structural Plasticity in Adult Offspring

Hippocampus, Journal Year: 2025, Volume and Issue: 35(2)

Published: Feb. 13, 2025

ABSTRACT Early protein malnutrition has been shown to affect the brain reward circuitry, leading enduring molecular, neurochemical, and behavioral alterations. This study explored how maternal restriction contributes anhedonia, a key depression symptom, focusing on hippocampal BDNF–TrkB signaling structural plasticity changes in CA1 subregion of dorsal hippocampus (DH). To achieve our goal, adult rats submitted schedule from 14th day gestation up 30 days age (PR‐rats) were subjected sucrose preference test (SPT) compared with animals fed normoprotein diet. Immediately after SPT, we assessed levels BDNF its receptor TrkB changes. Interestingly, PR‐rats showed significant decrease preference. Furthermore, perinatal protein‐restriction‐induced anhedonia correlated decreased p‐TrkB DH, alongside reduced dendritic spine density pyramidal neurons, particularly mature spines (i.e., stubby mushroom spines). These findings suggest that accompanied by remodeling neurons may contribute ability undernourished respond rewarding stimuli, increasing their vulnerability later life.

Language: Английский

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An approach to screen susceptible rats and efficacy of an antidepressive treatment after chronic stress.

IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Network Pharmacology-Guided Evaluation of Ginger and Cornelian Cherry Extracts Against Depression and Metabolic Dysfunction in Estrogen-Deficient Chronic Stressed Rats

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4829 - 4829

Published: May 18, 2025

This study investigated the therapeutic effects of water extracts from Zingiber officinale Roscoe (ginger) and Cornus officinalis Siebold Zucc. fruits (COF) on depression-like behavior metabolic dysfunction in estrogen-deficient rats exposed to chronic mild stress (CMS). Network pharmacology analysis identified three bioactive compounds ginger four COF, with 11 overlapping targets linked both depression pathways, primarily involving NR3C1, HTR2A, MAOA, SLC6A4 genes associated hypothalamic–pituitary–adrenal (HPA) axis regulation neurotransmitter modulation. Ovariectomized received 200 mg/kg/day or COF for 7 weeks, a 4-week CMS protocol initiated at week 3. Both significantly improved behaviors, memory performance, glucose tolerance, lipid profiles, bone mineral density, normalized HPA markers (corticosterone ACTH), increased hippocampal serotonin dopamine levels. Ginger demonstrated greater efficacy improving outcomes compared COF. Molecular docking further validated these findings, revealing strong stable interactions between key phytochemicals—such as hydroxygenkwanin telocinobufagin—and target proteins supporting their mechanistic role mood regulation. These results support supplementing promising botanical interventions estrogen-deficiency-related disorders, potential clinical application human-equivalent dose 1.5 g/day.

Language: Английский

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Lifetime history of major depressive disorder is associated with decreased reward learning: Evidence from a novel online version of the probabilistic reward task

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 350, P. 1007 - 1015

Published: Jan. 25, 2024

Language: Английский

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The presence of anhedonia in individuals with subacute and chronic stroke: an exploratory cohort study

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Feb. 7, 2024

Anhedonia refers to the diminished capacity experience pleasure. It has been described both as a symptom of depression and an enduring behavioral trait that contributes its development. Specifically, in stroke patients, anhedonia closely linked depression, resulting reduced sensitivity everyday pleasures intrinsic motivation engage rehabilitation programs maintain healthy active lifestyle. This condition may hinder patients' recovery, diminishing their autonomy, functioning, quality life. We aimed explore prevalence level those variables might be associated patients with ischemic hemorrhagic at subacute chronic phases disease. conducted exploratory cohort study sample 125 presenting upper-limb motor deficits. measured participants' four items from Beck Depression Inventory-II describe symptoms this condition: loss pleasure, interest, energy, interest sex. also collected demographic clinical information evaluated cognitive functions well levels apathy, various mood states. The results were compared 71 participants similar age, sex, education. Stroke demonstrated significantly higher (18.5-19.7%) controls (4.3%), regardless phase, impairment, other variables. Furthermore, post-stroke was lower negative states such fatigue anger long term. Importantly, superior than while controlling for confounding effects related emotional conditions. provides novel evidence on prevalence, factors post-stroke. emphasize importance assessing treating population, conducting large-scale longitudinal studies test influence long-term functional recovery.

Language: Английский

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The relationship of peripheral blood cell inflammatory biomarkers and psychological stress in unmedicated major depressive disorder

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 176, P. 155 - 162

Published: June 9, 2024

Recent research has explored the linkage between major depressive disorder (MDD) and inflammation, especially via altered peripheral blood immune markers. However, relationship several novel leukocyte-derived ratios (LDR) psychological stress in MDD remains uncertain. This study aimed to explore LDR, clinical characteristics, recent life events, childhood maltreatment patients.

Language: Английский

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