Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets DOI Creative Commons

Jhoan Aguilar,

Amy W. Lasek

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 33, P. 100692 - 100692

Published: Nov. 1, 2024

Perineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity. Most PNNs the brain surround parvalbumin-expressing inhibitory interneurons, which tightly excitatory/inhibitory balance activity associated with optimal cognitive functioning. Alterations have been observed neurological diseases psychiatric disorders, suggesting they may be key contributors to neuropathological progression behavioral changes these diseases. Alcohol use disorder (AUD), major depressive (MDD), chronic pain highly comorbid conditions, animal models as well postmortem tissue from individuals diagnosed AUD MDD. This review focuses on literature describing stress-, alcohol-, pain-induced adaptations PNNs, potential cellular altered role behaviors related disorders. Medicines can restore non-pathological state novel therapeutic approach treating pain, AUD,

Language: Английский

ANTIDEPRESSANT USE AND SIDE EFFECTS AMONG ADOLESCENTS: AN INTEGRATED REVIEW DOI Creative Commons

Sarah Ahmed Awad,

Amira Shahid Sheikh,

Mubashir Ahmad

et al.

Published: March 27, 2024

Introduction: Depression is a pervasive psychological condition impacting individuals of all ages, with particularly severe implications for young people and children, affecting their social, academic, familial functioning. This study investigates the intake antidepressants associated side effects among adolescents. Methods: An integrated review approach was employed, utilizing databases such as PubMed, SciELO, VHL, LILACS. Keywords including Depression, adolescence, mental health, antidepressant medications were used to retrieve relevant English-language human research published within last 20 years. Results: Pharmacotherapy plays vital role in managing depressive disorders adolescents, according existing findings debates. However, it must be part comprehensive therapeutic rooted thorough health assessments. Despite importance medication, there remains scarcity on its safety efficacy children adults. Conclusion: While medication an essential component treating warrant further investigation. There pressing need more studies fill gap literature provide guidelines use this vulnerable population.

Language: Английский

Citations

1
Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets DOI Creative Commons

Jhoan Aguilar,

Amy W. Lasek

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 33, P. 100692 - 100692

Published: Nov. 1, 2024

Perineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity. Most PNNs the brain surround parvalbumin-expressing inhibitory interneurons, which tightly excitatory/inhibitory balance activity associated with optimal cognitive functioning. Alterations have been observed neurological diseases psychiatric disorders, suggesting they may be key contributors to neuropathological progression behavioral changes these diseases. Alcohol use disorder (AUD), major depressive (MDD), chronic pain highly comorbid conditions, animal models as well postmortem tissue from individuals diagnosed AUD MDD. This review focuses on literature describing stress-, alcohol-, pain-induced adaptations PNNs, potential cellular altered role behaviors related disorders. Medicines can restore non-pathological state novel therapeutic approach treating pain, AUD,

Language: Английский

Citations

0