Retinal Microperimetry as a Novel Tool for Early Detection of Subclinical Cognitive Dysfunction and Brain Damage in Type 1 Diabetes: A Pilot Study DOI Creative Commons
Manuel Mateu‐Salat,

Nicole Stantonyonge,

Frederic Sampedro Santaló

et al.

Endocrinology Diabetes & Metabolism, Journal Year: 2024, Volume and Issue: 8(1)

Published: Dec. 21, 2024

ABSTRACT Context Retinal microperimetry (MPR) is a non‐invasive method that measures retinal light sensitivity (RS) and gaze fixation stability (GFS). MPR has been described as marker of cognitive impairment in people with Type 2 diabetes, but it never assessed 1 diabetes (T1D). Our group subclinical alterations, structural brain differences, increased levels chain neurofilament (NfL) T1D impaired awareness hypoglycaemia. Objective To measure RS GFS using individuals evaluate its correlation neuropsychological assessment, plasma NfL CGM‐derived glucometric parameters. Secondary objectives: to the possible differences depending on hypoglycaemia awareness. Design, Setting Participants Pilot observational study, without clinical impairment, moderate–severe retinopathy or glaucoma. was performed MAIA3. Results A total 30 subjects were studied: 40% women, age 58 ± 11 years; duration 31 9 years, mild 33%. 27.5 dB (26.1–28.3) GFS(%) 97.6% (93.5%–99.5%). We found between memory alteration tests ( p = 0.016) composite attention executive 0.025). An inverse time below range found. No NfL. Conclusion This first exploratory study supports potential utility screening tool for neurocognitive alterations this population.

Language: Английский

The relationship between diabetes and the dementia risk: a meta-analysis DOI Creative Commons
Fang Cao, Fushuang Yang, Jian Li

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 14, 2024

Abstract Background The link between diabetes and dementia risk is not well understood. This study evaluates the factors linking to onset, providing guidance for preventing in diabetic patients. Methods analysis utilized databases such as PubMed, Embase, Web of Science, Cochrane Library review literature from January 31, 2012, March 5, 2023. Articles were rigorously assessed using specific inclusion exclusion criteria. Newcastle-Ottawa Scale (NOS) was used evaluate quality studies. Data performed with STATA 15.0. Results analyzed 15 articles, covering 10,103,868 patients, 8,821,516 diagnosed diabetes. meta-analysis reveals a substantial association an increased [RR: 1.59, 95%CI (1.40–1.80), P < 0.01, I² =96.4%]. A duration less than five years linked higher 1.29, (1.20–1.39), =92.6%]. Additionally, hypoglycemia significantly raises 1.56, (1.13–2.16), =51.5%]. Analyses blood sugar control, glycated hemoglobin, fasting indicated no significant effects on onset dementia. Conclusion Diabetes notably increases risk, particularly where under or present. Registration research protocol registered PROSPERO assigned registration number CRD42023394942.

Language: Английский

Citations

9
Oculomics: Current Concepts and Evidence DOI Creative Commons
Zhuoting Zhu, Yueye Wang, Ziyi Qi

et al.

Progress in Retinal and Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 101350 - 101350

Published: March 1, 2025

Language: Английский

Citations

1
A Narrative Review on Cognitive Impairment in Type 2 Diabetes: Global Trends and Diagnostic Approaches DOI Creative Commons

Xiao-xing Liao,

Yibin Zhang,

Jialu Xu

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 473 - 473

Published: Feb. 14, 2025

Diabetes is a chronic disease that affects many people, with both its incidence and prevalence rising globally. can lead to various complications, among which cognitive impairment in diabetic patients significantly impacts their daily life blood glucose management, complicating treatment worsening prognosis. Therefore, the early diagnosis of are essential ensure health patients. However, there currently no widely accepted effective method for diabetes-related impairment. This review aims summarize potential screening diagnostic methods, as well biomarkers, diabetes, including retinal structure function examination, brain imaging, peripheral providing valuable information support clinical decision making future research.

Language: Английский

Citations

0
Deciphering the role of disturbed insulin signalling in brain disorders DOI
Jeanette C. Mostert, Barbara Franke, Janita Bralten

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106083 - 106083

Published: Feb. 1, 2025

Language: Английский

Citations

0
Graphene/amorphous MIL-101(Cr)-NH2 double layer composite for nonenzymatic sweat glucose sensing by voltammetry and chronoamperometry DOI
Jing Meng, Moustafa Zahran,

Ahmed S. Abou-Elyazed

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113560 - 113560

Published: April 1, 2025

Language: Английский

Citations

0
Abnormal eye movements: relationship with clinical symptoms and predictive value for Alzheimer’s disease DOI Creative Commons
Jing Qi,

Teng-hong Lian,

Peng Guo

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 21, 2024

Abnormal eye movements occur at the early stages of Alzheimer's disease (AD). However, characteristics abnormal patients with AD and their relationship clinical symptoms remain inconsistent, predictive value for diagnosing monitoring progression remains unclear.

Language: Английский

Citations

1
Retinal Microperimetry as a Novel Tool for Early Detection of Subclinical Cognitive Dysfunction and Brain Damage in Type 1 Diabetes: A Pilot Study DOI Creative Commons
Manuel Mateu‐Salat,

Nicole Stantonyonge,

Frederic Sampedro Santaló

et al.

Endocrinology Diabetes & Metabolism, Journal Year: 2024, Volume and Issue: 8(1)

Published: Dec. 21, 2024

ABSTRACT Context Retinal microperimetry (MPR) is a non‐invasive method that measures retinal light sensitivity (RS) and gaze fixation stability (GFS). MPR has been described as marker of cognitive impairment in people with Type 2 diabetes, but it never assessed 1 diabetes (T1D). Our group subclinical alterations, structural brain differences, increased levels chain neurofilament (NfL) T1D impaired awareness hypoglycaemia. Objective To measure RS GFS using individuals evaluate its correlation neuropsychological assessment, plasma NfL CGM‐derived glucometric parameters. Secondary objectives: to the possible differences depending on hypoglycaemia awareness. Design, Setting Participants Pilot observational study, without clinical impairment, moderate–severe retinopathy or glaucoma. was performed MAIA3. Results A total 30 subjects were studied: 40% women, age 58 ± 11 years; duration 31 9 years, mild 33%. 27.5 dB (26.1–28.3) GFS(%) 97.6% (93.5%–99.5%). We found between memory alteration tests ( p = 0.016) composite attention executive 0.025). An inverse time below range found. No NfL. Conclusion This first exploratory study supports potential utility screening tool for neurocognitive alterations this population.

Language: Английский

Citations

0