Innovations in noninvasive sensory stimulation treatments to combat Alzheimer’s disease DOI Creative Commons
Jung M. Park, Li‐Huei Tsai

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(2), P. e3003046 - e3003046

Published: Feb. 28, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide. There no known cure for AD, highlighting an urgent need new, innovative treatments. Recent studies have shed light on promising, noninvasive approach using sensory stimulation as potential therapy AD. Exposing patients to and sound pulses at frequency of 40 hertz induces brain rhythms in the gamma range that are important healthy activity. Using this treatment animal models, we now beginning understand molecular, cellular, circuit-level changes underlie improvements pathology, cognition, behavior. A mechanistic understanding basic biology underlies 40-hertz will inform ongoing clinical trials offer promising avenue without side effects high costs typically associated with pharmacological interventions. Concurrent advancements neurotechnology can also noninvasively stimulate illuminating new possibilities alternative therapies. Altogether, these approaches could herald era treating making them beacon hope patients, families, caregivers facing challenges debilitating condition.

Language: Английский

Innovations in noninvasive sensory stimulation treatments to combat Alzheimer’s disease DOI Creative Commons
Jung M. Park, Li‐Huei Tsai

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(2), P. e3003046 - e3003046

Published: Feb. 28, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide. There no known cure for AD, highlighting an urgent need new, innovative treatments. Recent studies have shed light on promising, noninvasive approach using sensory stimulation as potential therapy AD. Exposing patients to and sound pulses at frequency of 40 hertz induces brain rhythms in the gamma range that are important healthy activity. Using this treatment animal models, we now beginning understand molecular, cellular, circuit-level changes underlie improvements pathology, cognition, behavior. A mechanistic understanding basic biology underlies 40-hertz will inform ongoing clinical trials offer promising avenue without side effects high costs typically associated with pharmacological interventions. Concurrent advancements neurotechnology can also noninvasively stimulate illuminating new possibilities alternative therapies. Altogether, these approaches could herald era treating making them beacon hope patients, families, caregivers facing challenges debilitating condition.

Language: Английский

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