Oxytocin receptors in the nucleus accumbens shell are necessary for the onset of maternal behavior

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 2, 2024

In rodents, oxytocin (Oxt) contributes to the onset of maternal care by shifting perception pups from aversive attractive. Both Oxt receptor knockout (Oxtr -/-) and forebrain-specific Oxtr (FB/FB) dams abandon their first litters, likely due a failure brain 'switch' more state. Whether this behavioral shift is neurochemically similar in virgin females, who can display behaviors when repeatedly exposed pups, or what neuroanatomical substrate critical for remains unknown. To understand similarities differences signaling pup-sensitized FB/FB as opposed post-parturient -/- dams, behavior (pup-sensitized females only) immediate early gene activation were assessed. Pup-sensitized retrieved faster on day one testing had reduced c-Fos expression dorsal lateral septum compared +/+ females. This differs was observed where increased nucleus accumbens (NAcc) shell. Based these data, we then disrupted NAcc shell posterior paraventricular thalamus (pPVT) (control region) female floxed mice using Cre recombinase expressing adeno-associated virus. Knockout only prevented Our data suggest that may differ behavior.

Language: Английский

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Oxytocin receptors within the caudal lateral septum regulate social approach-avoidance, long-term social discrimination, and anxiety-like behaviors in adult male and female rats

Neuropharmacology, Journal Year: 2025, Volume and Issue: 271, P. 110409 - 110409

Published: March 11, 2025

OTR signaling promotes social approach or facilitates avoidance, depending on the brain region involved. The lateral septum plays a critical role in regulating interactions and memory. We investigated of caudodorsal (LSc.d) modulating approach-avoidance behavior, long-term discrimination memory, anxiety-like behaviors adult rats. Local infusion selective antagonist L-368,899 (1 μg/0.5 μl) into LSc.d decreased approach, increased vigilance, reduced memory both sexes. Administration biased OTR/Gq agonist carbetocin (0.5 sexes, had anxiogenic effects (increased latency to consume palatable food test arena) only males. In contrast, full TGOT (50 ng/0.5 no effect (anxiolytic effect). results indicate that oxytocin system can promote inhibit differential activation G-protein subunits β-arrestins, as well pivotal LS behavior

Language: Английский

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Neurobiology of social interactions across species

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106001 - 106001

Published: Jan. 1, 2025

Language: Английский

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