Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors DOI Open Access
Michel Fallah, Kenea C. Udobi, Aleksandra E Swiatek

et al.

Published: Oct. 30, 2024

The canonical basal ganglia model predicts that the substantia nigra pars reticulata (SNr) and globus pallidus externa (GPe) will have specific effects on locomotion: SNr inhibiting locomotion GPe enhancing it. In this manuscript, we use in vivo optogenetics to show a projection-defined neural subpopulation within each structure exerts non-canonical locomotion. These subpopulations are defined by their projection pedunculopontine nucleus (PPN) mediate opposing reward. To understand how these structures differentially modulate PPN, ex whole-cell recording with comprehensively dissect connections regionally– molecularly-defined populations of PPN neurons. inhibits all subtypes, but most strongly caudal glutamatergic selectively GABAergic neurons, avoiding both cholinergic rostral cells. This circuit characterization reveals pathways for valence.

Language: Английский

Neuromodulatory signaling contributing to the encoding of aversion DOI Creative Commons

Cheng-Hsi Wu,

Léa Camelot,

Salvatore Lecca

et al.

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

The appropriate and rapid encoding of stimuli bearing a negative valence enables behaviors that are essential for survival. Recent advances in neuroscience using rodents as model system highlight the relevance cell type-specific neuronal activities diverse brain networks aversion, well their importance subsequent behavioral strategies. Within these networks, neuromodulators influence excitability, adjust fast synaptic neurotransmission, affect plasticity, ultimately modulating behaviors. In this review we first discuss contemporary findings leveraging use cutting-edge neurotechnologies to define aversion-related neural circuits. spatial temporal dynamics release neuropeptides upon exposure aversive described within defined Together, mechanistic insights update present framework through which aversion drives motivated

Language: Английский

Citations

0
Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors. DOI Creative Commons
Michel Fallah, Kenea C. Udobi, Aleksandra E Swiatek

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

The canonical basal ganglia model predicts that the substantia nigra pars reticulata (SNr) and globus pallidus externa (GPe) will have specific effects on locomotion: SNr inhibiting locomotion GPe enhancing it. In this manuscript, we use in vivo optogenetics to show a projection-defined neural subpopulation within each structure exerts non-canonical locomotion. These subpopulations are defined by their projection pedunculopontine nucleus (PPN) mediate opposing reward. To understand how these structures differentially modulate PPN, ex whole-cell recording with comprehensively dissect connections regionally- molecularly-defined populations of PPN neurons. inhibits all subtypes, but most strongly caudal glutamatergic selectively GABAergic neurons, avoiding both cholinergic rostral cells. This circuit characterization reveals pathways for valence.

Language: Английский

Citations

0
Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors DOI Open Access
Michel Fallah, Kenea C. Udobi, Aleksandra E Swiatek

et al.

Published: Oct. 30, 2024

The canonical basal ganglia model predicts that the substantia nigra pars reticulata (SNr) and globus pallidus externa (GPe) will have specific effects on locomotion: SNr inhibiting locomotion GPe enhancing it. In this manuscript, we use in vivo optogenetics to show a projection-defined neural subpopulation within each structure exerts non-canonical locomotion. These subpopulations are defined by their projection pedunculopontine nucleus (PPN) mediate opposing reward. To understand how these structures differentially modulate PPN, ex whole-cell recording with comprehensively dissect connections regionally– molecularly-defined populations of PPN neurons. inhibits all subtypes, but most strongly caudal glutamatergic selectively GABAergic neurons, avoiding both cholinergic rostral cells. This circuit characterization reveals pathways for valence.

Language: Английский

Citations

0
Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke opposite motor and valence behaviors DOI Open Access
Michel Fallah, Kenea C. Udobi, Aleksandra E Swiatek

et al.

Published: Oct. 30, 2024

The canonical basal ganglia model predicts that the substantia nigra pars reticulata (SNr) and globus pallidus externa (GPe) will have specific effects on locomotion: SNr inhibiting locomotion GPe enhancing it. In this manuscript, we use in vivo optogenetics to show a projection-defined neural subpopulation within each structure exerts non-canonical locomotion. These subpopulations are defined by their projection pedunculopontine nucleus (PPN) mediate opposing reward. To understand how these structures differentially modulate PPN, ex whole-cell recording with comprehensively dissect connections regionally– molecularly-defined populations of PPN neurons. inhibits all subtypes, but most strongly caudal glutamatergic selectively GABAergic neurons, avoiding both cholinergic rostral cells. This circuit characterization reveals pathways for valence.

Language: Английский

Citations

0