Local functional connectivity abnormalities in mild cognitive impairment and Alzheimer's disease: A meta-analytic investigation using minimum Bayes factor activation likelihood estimation

NeuroImage, Journal Year: 2024, Volume and Issue: 298, P. 120798 - 120798

Published: Aug. 15, 2024

Functional magnetic resonance imaging research employing regional homogeneity (ReHo) analysis has uncovered aberrant local brain connectivity in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) comparison healthy controls. However, the precise localization, extent, possible overlap of these aberrations are still not fully understood. To bridge this gap, we applied a novel meta-analytic Bayesian method (minimum Bayes Factor Activation Likelihood Estimation, mBF-ALE) for systematic exploration functional alterations MCI AD brains. We extracted ReHo data via standardized MEDLINE database search, which included 35 peer-reviewed experiments, 1,256 or MCI, 1,118 controls, 205 x-y-z coordinates variation. then separated into two distinct datasets: one other AD. Two mBF-ALE analyses were conducted, thresholded at "very strong evidence" (mBF ≥ 150), minimum cluster size 200 mm³. also assessed spatial consistency sensitivity our results using canonical version ALE algorithm. For observed clusters decrease increase. Decreased was notable left precuneus (Brodmann area - BA 7) inferior temporal gyrus (BA 20), while increased evident right parahippocampal 36). The confirmed locations, except gyrus. In AD, each increase found, decreased posterior cingulate cortex 30 extending to 23) 31). These locations by ALE. identification patterns sheds new light on complex pathophysiology offering promising directions future neuroimaging-based interventions. Additionally, use framework statistical thresholding enhances robustness neuroimaging meta-analyses, broadening its applicability small datasets.

Language: Английский

Gray Matter Volume Correlates of Co-Occurring Depression in Autism Spectrum Disorder

Journal of Autism and Developmental Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Language: Английский

Structural and functional whole brain changes in autism spectrum disorder at different age stages

European Child & Adolescent Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Language: Английский