Myelin oligodendrocyte glycoprotein-associated transverse myelitis after SARS-CoV-2 infection: A case report DOI Open Access

Jian-Rong Zheng,

Junlei Chang, Jun Hu

et al.

World Journal of Radiology, Journal Year: 2024, Volume and Issue: 16(9), P. 446 - 452

Published: Sept. 26, 2024

BACKGROUND Cases of myelin oligodendrocyte glycoprotein (MOG) antibody-related disease have a history coronavirus 2019 infection or its vaccination before onset. Severe acute respiratory syndrome virus 2 (SARS-CoV-2) has been considered to be trigger central nervous system autoimmune diseases. CASE SUMMARY Here we report 20-year male with MOG-associated transverse myelitis after SARS-CoV-2 infection. The patient received near-complete recovery standard immunological treatments. CONCLUSION Attention should paid the evaluation typical atypical neurological symptoms that may triggered by

Language: Английский

The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19 DOI Creative Commons
Xuan Niu,

Wenrui Bao,

Zhaoyao Luo

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: 306, P. 121011 - 121011

Published: Jan. 9, 2025

Language: Английский

Citations

0
Neuroimaging insights into lung disease-related brain changes: from structure to function DOI Creative Commons
Miao He, Yubo Liu,

Zhongtian Guan

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Feb. 20, 2025

Lung diseases induce changes in brain structure and function, leading to a range of cognitive, emotional, motor deficits. The concept the lung-brain axis has been proposed through neuroanatomy, endocrine, immune pathway, while considerable number studies also explored existence from neuroimaging perspective. This survey summarizes exploring relationship between lung disease function perspective, particular magnetic resonance imaging (MRI). We have collated existing categorized them into four types: chronic obstructive pulmonary (COPD), coronavirus 2019 (COVID-19), cancer other diseases. observed structural functional cognitive dysfunction induced by are discussed. present distinct pattern various Neuroimaging COPD concentrated frontal lobes, including gray matter atrophy, white damage, reduced perfusion. Patients with COVID-19 exhibit extensive microhemorrhages neuroinflammation, regions functionally connected primary olfactory cortex show greater changes. For patients, mainly attributed neurotoxicity radiotherapy chemotherapy, damage subcortical structures, patients pain demonstrate hyperconnectivity visual networks. discusses pathological mechanisms revealed clinical significance current studies. Finally, we analyzed limitations, terms small sample size, non-standardized criteria, reliance on correlation analyses, lack longitudinal studies, absence reliable biomarkers. suggest future research directions should include leveraging artificial intelligence for biomarker development, conducting multicenter investigating systemic effects neuromodulation strategies.

Language: Английский

Citations

0
Elucidating SARS-CoV-2 Neurotropism: A Comprehensive Mendelian Randomization Study on Cerebrospinal Fluid Biomarkers and their Relevance to COVID-19 Neurological Manifestations DOI

Ziyan Wu,

Honglin Xu,

Siyuan Fan

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Abstract A mendelian randomization (MR) analysis was conducted to investigate whether SARS-CoV-2 invaded the human nervous system. This confirmed by an increase in biomarkers found cerebrospinal fluid (CSF) and plasma of COVID-19 patients. To confirm neuroinvasive properties SARS-CoV-2, a series analyses were utilizing accessible datasets MR. In addition, external validation testing specific proteins retrospective cohort study, which included 40 patients with neurological complications 15 disease controls (DC). Our investigation revealed hospitalization, severity increased area volume certain brain regions, but no other significant causal effects imaging-derived phenotypes (IDPs) on COVID-19. Notably, hospitalization significantly left caudal middle frontal gyrus (p_fdr = 0.012; p_fdr 0.012, respectively). Additionally, linked area, right anterior-cingulate cortex cuneus 0.023; 0.025; 0.026, CSF patients, median level CHI3L1 higher (13677 pg/mL) compared DC group (8421 pg/mL, p < 1.00E-04). Similar trends also KLK6 NGF-β. NRGN (1013.00 control (360.00 6.50E-03). subgroup demonstrated that experiencing moderate critical symptoms exhibited levels GFAP their those without. Elevated S100B decreased consciousness comorbidities. MR provided evidence may invade system, as indicated CHI3L1, NGF-β, These findings suggested neuroinflammation could be potential mechanism underlying seen

Language: Английский

Citations

0
Dynamic brain glymphatic changes and cognitive function in COVID-19 recovered patients: a DTI-ALPS prospective cohort study DOI Creative Commons
Chengcheng He, Jindong Xie, Weiwei Fang

et al.

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

Objective This study aimed to evaluate brain glymphatic function in COVID-19 recovered patients using the non-invasive Diffusion Tensor Imaging-Analysis Along Perivascular Space (DTI-ALPS) technique. The DTI-ALPS technique was employed investigate changes these and explore correlations with cognitive fatigue. Materials methods Follow-up assessments were conducted at 1, 3, 12 months post-recovery. A total of 31 completed follow-ups all three time points, 30 healthy controls (HCs) for comparison. Results Compared HCs, showed a significant decline MoCA scores 3 post-recovery ( p &lt; 0.05), which returned near-normal levels by months. Mental fatigue, measured Fatigue Assessment Scale (FAS), significantly higher follow-up points compared HCs 0.05). index both hemispheres differences 0.001), indicating increased activity. Longitudinal analysis revealed peak post-recovery, then decreased Correlation negative correlation between Bilateral hemisphere (right side: r = −0.373, 0.003; left −0.255, 0.047), positive mental fatigue 0.275, 0.032; 0.317, 0.013). Conclusion demonstrates dynamic patients, activity These are associated suggesting potential targets addressing neurological symptoms long COVID. proves be valuable tool assessing this population.

Language: Английский

Citations

0
Elucidating SARS-CoV-2 neurotropism: a comprehensive Mendelian randomization study on cerebrospinal fluid biomarkers and their relevance to COVID-19 neurological manifestations DOI Creative Commons

Ziyan Wu,

Honglin Xu,

Siyuan Fan

et al.

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 28, 2025

Language: Английский

Citations

0
Persistent neurocognitive deficits in long COVID: Evidence of structural changes and network abnormalities following mild infection DOI
Bedia Samancı, Ulaş Ay, Haşim Gezegen

et al.

Cortex, Journal Year: 2025, Volume and Issue: 187, P. 98 - 110

Published: May 2, 2025

Language: Английский

Citations

0
A multimodal neuroimaging meta-analysis of functional and structural brain abnormalities in attention-deficit/hyperactivity disorder DOI
Chao Chen, Shilin Sun,

Ruoyi Chen

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown, P. 111199 - 111199

Published: Nov. 1, 2024

Language: Английский

Citations

1
Myelin oligodendrocyte glycoprotein-associated transverse myelitis after SARS-CoV-2 infection: A case report DOI Open Access

Jian-Rong Zheng,

Junlei Chang, Jun Hu

et al.

World Journal of Radiology, Journal Year: 2024, Volume and Issue: 16(9), P. 446 - 452

Published: Sept. 26, 2024

BACKGROUND Cases of myelin oligodendrocyte glycoprotein (MOG) antibody-related disease have a history coronavirus 2019 infection or its vaccination before onset. Severe acute respiratory syndrome virus 2 (SARS-CoV-2) has been considered to be trigger central nervous system autoimmune diseases. CASE SUMMARY Here we report 20-year male with MOG-associated transverse myelitis after SARS-CoV-2 infection. The patient received near-complete recovery standard immunological treatments. CONCLUSION Attention should paid the evaluation typical atypical neurological symptoms that may triggered by

Language: Английский

Citations

0