Daytime Dysfunction: Symptoms Associated with Nervous System Disorders Mediated by SIRT1 DOI Creative Commons

T. Edgar Huang,

Xianxie Zhang, Ling Qi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2070 - 2070

Published: Sept. 11, 2024

Daytime dysfunction, including symptoms like sleepiness, poor memory, and reduced responsiveness, is not well researched. It crucial to develop animal models study the biological mechanisms involved. We simulated sleep disorders through deprivation, stressful stimuli were used establish daytime functional models. tests sodium pentobarbital synergy test DSI telemetry system measure duration structure. also Morris water maze, open field test, grip baton twirling assess mental physical fatigue. To intrinsic mechanisms, we measured sleep-wake-related neurotransmitters related receptor proteins, circadian rhythm-related proteins cognition-related in hypothalamus tissue, oxidative stress, inflammatory factors, S100β, HPA axis-related indexes serum. Multi-factor deprivation resulted disruption of sleep-wakefulness structure, memory-cognitive function degradation, decreased coordination, other manifestations energetic strength. The disturbed expression sleep-wake, rhythm, memory-cognition-related as significant elevation axis, indicators. Intrinsically sirt1 can lead rhythms; resulting their neurotransmitter content expression. Meanwhile, synapse-associated proteins. This prepared an model dysfunction by means multi-factor deprivation. With a core target, relevant neurological modulated.

Language: Английский

The Extract of Piper nigrum Improves the Cognitive Impairment and Mood in Sleep-Deprived Mice Through the JAK1/STAT3 Signalling Pathway DOI Open Access

Dongyan Guan,

Zhiying Hou,

Bei Fan

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1842 - 1842

Published: Feb. 21, 2025

Piper nigrum L. (PN), which contains various bioactive compounds, is a plant with homologous medicine and food. Sleep deprivation (SD) profoundly impacts cognitive function emotional health. However, the mechanisms by PN improves depressive mood induced SD remain unclear. In our study, network pharmacology molecular docking techniques were used to predict potential regulates SD. this 220 compounds identified in PN, 10 core targets screened through pharmacology. Animal experiments showed that ameliorated deficits sleep-deprived mice, upregulated serum activities of superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), downregulated malondialdehyde (MDA) levels. The ELISA assay significantly decreased tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β) Histopathological staining brain tissue demonstrated mitigates SD-induced hippocampal damage, enables hippocampus produce more neurotransmitters, including 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (GABA), dopamine (DA), reduces glutamate (Glu) RT-qPCR WB analyses further indicated could exert anti-SD effects inhibiting over-activation JAK1/STAT3 signalling pathway. PC12 cell model, reduce inflammation prevent apoptosis, exerting neuroprotective effects. summary, has positive on alleviating symptoms dysfunction

Language: Английский

Citations

0
Echoes in the night: How sleep quality influences auditory health DOI
Peng Zhang, Xiaogang An,

Runqin Yang

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Daytime Dysfunction: Symptoms Associated with Nervous System Disorders Mediated by SIRT1 DOI Creative Commons

T. Edgar Huang,

Xianxie Zhang, Ling Qi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2070 - 2070

Published: Sept. 11, 2024

Daytime dysfunction, including symptoms like sleepiness, poor memory, and reduced responsiveness, is not well researched. It crucial to develop animal models study the biological mechanisms involved. We simulated sleep disorders through deprivation, stressful stimuli were used establish daytime functional models. tests sodium pentobarbital synergy test DSI telemetry system measure duration structure. also Morris water maze, open field test, grip baton twirling assess mental physical fatigue. To intrinsic mechanisms, we measured sleep-wake-related neurotransmitters related receptor proteins, circadian rhythm-related proteins cognition-related in hypothalamus tissue, oxidative stress, inflammatory factors, S100β, HPA axis-related indexes serum. Multi-factor deprivation resulted disruption of sleep-wakefulness structure, memory-cognitive function degradation, decreased coordination, other manifestations energetic strength. The disturbed expression sleep-wake, rhythm, memory-cognition-related as significant elevation axis, indicators. Intrinsically sirt1 can lead rhythms; resulting their neurotransmitter content expression. Meanwhile, synapse-associated proteins. This prepared an model dysfunction by means multi-factor deprivation. With a core target, relevant neurological modulated.

Language: Английский

Citations

3