Dissociable neurofunctional and molecular characterizations of reward and punishment sensitivity DOI Creative Commons
Ting Xu,

Chunhong Zhu,

Xinqi Zhou

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract While the hyper-and hypo-reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, lack an overarching neurobiological characterization currently limits their early identifications and neuromodulations. Here we combined microarray data from Allen Human Brain Atlas with a multimodal fMRI approach to uncover signatures RS PS in discovery-replication design (N=655 participants). Both were mapped separately brain, intrinsic functional connectome fronto-striatal network encoding reward responsiveness, while fronto-insular system was particularly engaged sensitivity. This dissociable patterns related also specific differentiating decisions driven by social monetary motivations. Further imaging transcriptomic analyses revealed that variations for associated topography gene sets enriched ontological pathways, including synaptic transmission, dopaminergic metabolism, immune response stress adaptation. On neurotransmitter level, serotonin neuromodulator identified pivotal hub regulating PS, this process critically dependent on its interactions dopaminergic, opioid GABAergic systems. Overall, these findings indicate neural mapping highlight linkage profiles, which may offer valuable insights into treatment evaluation symptomatology relevant reward/punishment processing deficits.

Language: Английский

Sex-specific differences in peripheral blood metabolites and biological functions in major depressive disorder: a systematic review and meta-analysis DOI
Zhengyang Wang, Yajie Xiang,

Ruozhi Dang

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 170, P. 106052 - 106052

Published: Feb. 5, 2025

Language: Английский

Citations

0
Temporomandibular disorders and mental health: shared etiologies and treatment approaches DOI Creative Commons

Jiamin Wan,

Jiu Lin,

Tingfeng Zha

et al.

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 12, 2025

The biopsychosocial model suggests that temporomandibular disorders (TMDs) often coexist with mental health disorders, particularly depression and anxiety, affecting a significant portion of the global population. interplay between TMDs contributes to complex comorbidity, perpetuating cycle mutual influence reinforcement. This review investigates neurobiological mechanisms epidemiological evidence supporting shared etiology exploring potential vulnerabilities bidirectional causal relationships. Shared may stem from genetic epigenetic predispositions, psychosocial factors, behavioral aspects. Inflammatory cytokines, neurotransmitters, neurotrophins, neuropeptides play pivotal roles in both peripheral central sensitization as well neuroinflammation. Brain imaging studies suggest exhibit overlapping brain regions indicative reward processing deficits anomalies within triple network model. Future research efforts are crucial for developing comprehensive understanding underlying confirming reciprocal effects disorders. provides valuable insights oral healthcare professionals, stressing importance optimizing treatment strategies individuals dealing concurrent issues through personalized, holistic, multidisciplinary approach.

Language: Английский

Citations

0
Identifying early screening factors for depression in middle-aged and older adults: A cohort study DOI Creative Commons
Guanqun Chao, Lan Zhang,

Zheli Zhan

et al.

Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

This study aims to explore the current status of depression and related factors in middle-aged elderly people China using a cohort database with multi-year follow-up. The population for this project was derived from Health Retirement Longitudinal Study. Participants were divided into control groups based on scores Center Epidemiological Research Depression Scale. Continuous variables compared t-tests or Mann-Whitney U tests, while categorical chi-square tests. A multivariate logistic regression model employed evaluate associated depression. total 9,749 participants included study. Correlation analyses revealed that age, body mass index, diastolic blood pressure, waist circumference, cholesterol, uric acid, length sleep significantly (p < 0.05). Women exhibited higher risk middle old age men An increase circumference decreased Longer duration educational levels also reduced Unfavorable marital frequency alcohol consumption found In individuals, women, low education level, experiencing dissatisfaction marriage are connected high On other hand, increased moderate consumption, longer

Language: Английский

Citations

0
The psychopathology of mood disorders: implications for identifying neurocognitive intervention targets DOI Creative Commons
Roland Zahn

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 119423 - 119423

Published: May 1, 2025

Neurofeedback and neuromodulation treatments are of increasing clinical interest, but their neurocognitive targets poorly understood. In this review, we will use Jaspers' phenomenological psychopathology combined with modern network analysis to identify treatment by focussing on distinctive necessary symptoms mood disorders as well subsyndromal prognostic variations. We discuss the early descriptions Kraepelin's mixed affective states suggest a model four (depressed, anxious, irritable, elated) dynamic evolution mixing. Blame praise internalisation externalisation biases proposed key mechanisms underpinning states, together approach/withdrawal-related action tendencies. Whilst self-worth interest emerge most symptom dimensions, that for bipolar recurrent unipolar depressive disorders, also anxiety potential primary in subgroup chronic depression. Based neuroanatomical conceptual self, anterior temporal subgenual networks importance self-blame worthlessness, hypothesised role septo-hypothalamic affiliative discussed. The latter is distinguished from ventral striatal relevant more general approach-related tendencies hedonic (anticipatory anhedonia). Finally, recent target validation early-stage fMRI neurofeedback trials reviewed. It was not feasible employ systematic review approach. studies only new treatments, enhancing our pathophysiological understanding could gain impact ongoing advances scalable neurotechnologies.

Language: Английский

Citations

0
Dysfunctional mesocorticolimbic circuitry in cluster headache DOI Creative Commons
Stefania Ferraro, Greta Demichelis, Jean Paul Medina

et al.

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: May 19, 2025

Language: Английский

Citations

0
Bibliometric analysis of research hotspots and trends on the relationship between the gut microbiota and depression from 2020 to 2024 DOI Creative Commons

Dingwen Xu,

Jinnan Wu,

Zhihua Lu

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 11, 2024

In recent years, an increasing body of research has illustrated a strong correlation between gut microbiota and depression. However, there yet to be comprehensive discussion or summary the latest advancements trends in this field.

Language: Английский

Citations

0
Dissociable neurofunctional and molecular characterizations of reward and punishment sensitivity DOI Creative Commons
Ting Xu,

Chunhong Zhu,

Xinqi Zhou

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract While the hyper-and hypo-reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, lack an overarching neurobiological characterization currently limits their early identifications and neuromodulations. Here we combined microarray data from Allen Human Brain Atlas with a multimodal fMRI approach to uncover signatures RS PS in discovery-replication design (N=655 participants). Both were mapped separately brain, intrinsic functional connectome fronto-striatal network encoding reward responsiveness, while fronto-insular system was particularly engaged sensitivity. This dissociable patterns related also specific differentiating decisions driven by social monetary motivations. Further imaging transcriptomic analyses revealed that variations for associated topography gene sets enriched ontological pathways, including synaptic transmission, dopaminergic metabolism, immune response stress adaptation. On neurotransmitter level, serotonin neuromodulator identified pivotal hub regulating PS, this process critically dependent on its interactions dopaminergic, opioid GABAergic systems. Overall, these findings indicate neural mapping highlight linkage profiles, which may offer valuable insights into treatment evaluation symptomatology relevant reward/punishment processing deficits.

Language: Английский

Citations

0