Anxiety, brain structure and socioeconomic status in middle-aged and older adults DOI Creative Commons
Sasha Johns, Caroline Lea‐Carnall, Nick Shryane

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Anxiety disorders confer a significant global burden, impacting mental health, quality of life, and well-being, particularly in aging populations. Prior studies showed the association between anxiety abnormal brain structure, socioeconomic status (SES) is linked with both structure. However, limited research considers interaction these three factors, older adults. Multivariate regression analysis was conducted using 27,563 participants from UK Biobank to investigate relationship volume 30 cortical subcortical regions for whole sample separately by sex. It then investigated whether SES affects this relationship. Five out had negative associations population. These were thalamus, gyrus, insular cortex, supramarginal gyrus precentral but relationships abolished each area apart when included analyses. For females, no found. males, lower significantly associated higher anxiety, longer considered. The most robustly across conditions that may affect not excluded time assessment scans varied widely participants. Information about past during development also available. To conclude, affected SES. Clinicians researchers should take into account working imaging data.

Language: Английский

Anxiety, brain structure and socioeconomic status in middle-aged and older adults DOI Creative Commons
Sasha Johns, Caroline Lea‐Carnall, Nick Shryane

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Anxiety disorders confer a significant global burden, impacting mental health, quality of life, and well-being, particularly in aging populations. Prior studies showed the association between anxiety abnormal brain structure, socioeconomic status (SES) is linked with both structure. However, limited research considers interaction these three factors, older adults. Multivariate regression analysis was conducted using 27,563 participants from UK Biobank to investigate relationship volume 30 cortical subcortical regions for whole sample separately by sex. It then investigated whether SES affects this relationship. Five out had negative associations population. These were thalamus, gyrus, insular cortex, supramarginal gyrus precentral but relationships abolished each area apart when included analyses. For females, no found. males, lower significantly associated higher anxiety, longer considered. The most robustly across conditions that may affect not excluded time assessment scans varied widely participants. Information about past during development also available. To conclude, affected SES. Clinicians researchers should take into account working imaging data.

Language: Английский

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