Exploration of neuroscience, Journal Year: 2025, Volume and Issue: 4
Published: March 24, 2025
Aim: Alzheimer’s disease (AD) is associated with several electrophysiological biomarkers. These biomarkers are global decline in cognition and a diagnosis of AD. However, specific biomarker not characterized as normal-functioning older adults convert to The longitudinal retrospective study was conducted describe an indicator for AD the continuum over 2-year period. Methods: 54 community-residing adults, ranging from normal functioning All initial follow-up evaluations were completed New York University Brain Research Laboratories, overall assessments Global Deterioration Scale (GDS) Aging Dementia Center. Data included measurements GDS raw resting-state electroencephalogram (rsEEG), which transformed into quantitative EEG (qEEG) data. analysis consisted descriptive statistics Kruskal-Wallis test. level significance 0.05 moderate effect size. Topographic brain images displayed Results: A consistently increasing rsEEG theta frequency (P ≤ 0.01) occurred converted across all stages frontal posterior regions progressive decline. No discernible consistent changes observed delta, alpha, or beta frequencies stages. differed at baseline 0.01). increased Conclusions: may be within continuum. This will enhance assessment risk, onset, progression potentially inform treatment
Language: Английский