Congenital cytomegalovirus retinitis of prematurity: a case report and literature review

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: April 3, 2025

Ophthalmopathy induced by cytomegalovirus (CMV) infection is most common in immunodeficient patients without other congenital infections. This paper reports a clinical case of retinitis due to CMV preterm infant and reviews the relevant literature. A 2-day-old female at 36+2 gestation weeks presented with 2-day history scattered bleeding spots across body, hemorrhagic diathesis, thrombocytopenia, positive blood IgM, urine DNA levels significantly above detection limit PCR analysis. Maternal serological examination indicated IgM positivity. The laboratory test results, positivity mother's was used confirm diagnosis infection. Later, antiviral treatment ganciclovir provided for 3 weeks. Fundus few white exudates along peripheral retina both eyes, sheath retinal vessels temporal plane right eye. considered after obtaining abnormal fluorescein fundus angiography results. Ganciclovir administered 0.5 mg weekly into vitreous cavities eyes weeks, vascular sheaths disappeared. Retinitis recurred 6 months age, recommended. However, family rejected it. Congenital carries substantial risks. For infants suspected this condition, early initiation therapy crucial enable timely intervention, improve prognosis, enhance child's quality life.

Language: Английский

Parahydrogen-Hyperpolarized Propane-d₆ Gas Contrast Agent: T₁ Relaxation Dynamics and Pilot Millimeter-Scale Ventilation MRI

The Journal of Physical Chemistry A, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Hyperpolarized (HP) MRI provides enhanced signals over conventional due to the increase in nuclear spin polarization by orders of magnitude compared thermal polarization. Therefore, HP can be successfully utilized toward imaging low-density gases void spaces, such as human lungs. Specifically, clinical pulmonary imaging, employs a gaseous contrast agent that fills lungs during inhalation under physiologically relevant conditions prior imaging. FDA-approved 129Xe gas now used first inhalable for functional lung adults and pediatric patients above 12 years diagnosis monitoring responses treatment many diseases. However, despite substantial success research settings, production this novel remain expensive not universally available on scanners. An alternative approach is deploy proton-hyperpolarized cheap fast produce detected any scanner without modification. propane has recently emerged potential next-generation hyperpolarized agent. Here, relaxation dynamics two deuterated isotopologues have been explored at clinically 1 atm pressure 0.35 1.4 T magnetic fields using pairwise addition parahydrogen corresponding unsaturated precursor heterogeneous Rh/TiO2 catalyst. The T1 time propane-d6 (0.91±0.03 s) was found similar (0.81±0.06 because dominating mechanism coupling spins molecular rotation these isotopologues. Moreover, effective decay constant increases 1.35±0.05 s (and 1.35±0.10 T, pointing likely "partial" presence long-lived states (LLSS) field, intermediate spin-spin regime parahydrogen-derived sites. Furthermore, pilot feasibility rapid ventilation with × 9 mm2 voxel-size spatial resolution open demonstrated inflating excised rabbit lungs, reduction 0.78 ± 0.02

Language: Английский

ASAP1 protein macromolecule promotes the growth and development of gastric cancer cells and the remodeling of F-actin cytoskeleton: Expression of VEGF and HIF-1 α proteins

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 315, P. 144589 - 144589

Published: May 26, 2025

Language: Английский