Journal of Neurochemistry, Journal Year: 2015, Volume and Issue: 136(4), P. 677 - 691

Published: Nov. 26, 2015

Manganese (Mn) is an essential element required for many physiological functions. While it at levels, excessive accumulation of Mn in the brain causes severe dysfunctions central nervous system known as manganism. Manganism extrapyramidal disorder characterized by motor disturbances associated with neuropsychiatric and cognitive disabilities similar to Parkinsonism. As primary regions targeted are basal ganglia, be involved pathophysiology disorders, this review will examine impact exposure on ganglia circuitry neurotransmitters relation non-motor disorders. The collected data from recent available studies humans experimental animal models provide new information about mechanisms which affects behavior, neurotransmitters, function observed effects alterations metals neurochemical functioning critical develop effective modalities not only treatment vulnerable populations (e.g., Mn-exposed workers) but also understanding etiology neurodegenerative diseases where metal imbalances involved, such Parkinson's disease. We manganese show that when accumulated globus pallidus, influences subthalamic (STN) substantia nigra (SN) neurons, origin changes thalamus cortex.

Language: Английский