Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study DOI Creative Commons

Hongwei Wang,

Fangying Tian,

C W. Yang

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 26, 2024

Helicobacter pylori (Hp) infection and metabolic syndrome (MetS) have a high prevalence of co-morbidities both pose significant threat to human health survival. It has been suggested that Hp affects the development MetS in host, but causal relationship between two not confirmed. We conducted two-sample Mendelian randomization study investigate effect with its components. Summary statistics for exposure factors (Hp infection) were obtained from GWAS Catalog (anti-Hp IgG, n = 8,735; VacA antibody levels, 1,571; GroEL 2,716; OMP 2,640). outcome most comprehensive genome-wide association (GWAS) currently available (n 291,107) as well components MetS: fasting glucose 46,186), hypertension 461,880), serum triglycerides 115,082), waist circumference 21,949), high-density lipoprotein 400, 754). The inverse-variance weighted (IVW) method was used primary MR robustness results assessed through sensitivity analyses. analysis showed anti-Hp IgG levels positively correlated (β 0.08, P 0.012), an opposite correlation HDL (β= -0.03, 0.025) TG 0.02, 0.045). In contrast, antibodies FBG 0.064, 0.037 β 0.09, 0.003). estimation IVW main method, level associated negatively 0.008 β= -0.02, 0.007). Meanwhile, analyses no heterogeneity or pleiotropy. Our suggests there is Mets diagnosis composition, further studies are needed understand mechanism influence.

Language: Английский

Potential impact of Helicobacter pylori infection on primary-angle closure glaucoma and primary open-angle glaucoma pathophysiology DOI
Jannis Kountouras, Christos Zavos, Ioannis S. Papanikolaou

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Helicobacter pylori infection in the pathophysiology of metabolic dysfunction-associated steatotic liver disease and its complications DOI Creative Commons
Jannis Kountouras, Christos Zavos,

Ioannis S. Papanikolaou

et al.

Published: March 20, 2025

Language: Английский

Citations

0
Letter: Role of Helicobacter pylori and metabolic syndrome‐related insulin resistance and lipotoxicity in the pathogenesis of MAFLD and MASH DOI Open Access
Jannis Kountouras, Stergios A. Pοlyzos, Evangelos Kazakos

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(5), P. 660 - 661

Published: July 30, 2024

LINKED CONTENT This article is linked to Lin et al papers. To view these articles, visit https://doi.org/10.1111/apt.17930 and https://doi.org/10.1111/apt.18182 .

Language: Английский

Citations

2
Letter: Helicobacter pylori and metabolic syndrome‐related von Willebrand factor and plasminogen activator inhibitor‐1 activity levels for outcome prediction of advanced chronic liver disease DOI
Jannis Kountouras, Stergios A. Pοlyzos, Evangelos Kazakos

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(4), P. 540 - 541

Published: July 3, 2024

LINKED CONTENT This article is linked to Dominik et al papers. To view these articles, visit https://doi.org/10.1111/apt.17945 and https://doi.org/10.1111/apt.18144

Language: Английский

Citations

1
The 1st EoETALY consensus on the diagnosis and management of eosinophilic esophagitis and the missing link: Helicobacter pylori infection DOI
Michael Doulberis, Apostolis Papaefthymiou, Evangelos Kazakos

et al.

Digestive and Liver Disease, Journal Year: 2024, Volume and Issue: 56(11), P. 1946 - 1947

Published: July 26, 2024

Language: Английский

Citations

1
Helicobacter pylori Infection and Cholelithiasis DOI
Evangelos Kazakos, Jannis Kountouras

Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Language: Английский

Citations

0
Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study DOI Creative Commons

Hongwei Wang,

Fangying Tian,

C W. Yang

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 26, 2024

Helicobacter pylori (Hp) infection and metabolic syndrome (MetS) have a high prevalence of co-morbidities both pose significant threat to human health survival. It has been suggested that Hp affects the development MetS in host, but causal relationship between two not confirmed. We conducted two-sample Mendelian randomization study investigate effect with its components. Summary statistics for exposure factors (Hp infection) were obtained from GWAS Catalog (anti-Hp IgG, n = 8,735; VacA antibody levels, 1,571; GroEL 2,716; OMP 2,640). outcome most comprehensive genome-wide association (GWAS) currently available (n 291,107) as well components MetS: fasting glucose 46,186), hypertension 461,880), serum triglycerides 115,082), waist circumference 21,949), high-density lipoprotein 400, 754). The inverse-variance weighted (IVW) method was used primary MR robustness results assessed through sensitivity analyses. analysis showed anti-Hp IgG levels positively correlated (β 0.08, P 0.012), an opposite correlation HDL (β= -0.03, 0.025) TG 0.02, 0.045). In contrast, antibodies FBG 0.064, 0.037 β 0.09, 0.003). estimation IVW main method, level associated negatively 0.008 β= -0.02, 0.007). Meanwhile, analyses no heterogeneity or pleiotropy. Our suggests there is Mets diagnosis composition, further studies are needed understand mechanism influence.

Language: Английский

Citations

0