Can the Atherogenic Index of Plasma (AIP) Be a Prognostic Marker for Good Clinical Outcome After Mechanical Thrombectomy for Acute Ischemic Stroke? DOI Creative Commons
Sena Boncuk Ulaş, Türkan Acar, Halil Alper Eryılmaz

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(8), P. 947 - 947

Published: April 8, 2025

Background: Stroke remains a leading cause of morbidity and mortality worldwide, with dyslipidemia playing crucial role in atherosclerosis stroke development. The Atherogenic Index Plasma (AIP), calculated as log(triglyceride/HDL), has emerged biomarker for cardiovascular risk. However, its relationship prognosis unclear. This study aimed to investigate the association between AIP favorable clinical outcomes at three months acute ischemic patients undergoing mechanical thrombectomy. Methods: We conducted retrospective analysis 222 who underwent thrombectomy December 2019 April 2023. demographic variables, etiology, successful recanalization, intracerebral hemorrhage, three-month mRS was evaluated. values were compared good (mRS 0–2) poor 3–6) outcomes. Results: most common comorbidity hypertension (72.1%), followed by AF (50%). etiologies included large artery (16.2%), cardioembolism (57.2%), undetermined causes (26.6%). significantly lower functional Additionally, inversely associated but positively correlated DM previous history. No significant observed recanalization or hemorrhage. Conclusions: is first demonstrate that elevated after Given strong correlation prognosis, may serve valuable identifying high-risk patients. Future prospective studies are needed further validate these findings explore potential management.

Language: Английский

Unravelling neuroregenerative and neuroprotective roles of Wnt/β-catenin pathway in ischemic stroke: Insights into molecular mechanisms DOI

Srikanth Yadava,

Dontiboina Harikrishna Reddy,

Venkata Prasuja Nakka

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

6
Veterinary medical care in rodent models of stroke: Pitfalls and refinements to balance quality of science and animal welfare DOI Creative Commons
Sara Gargiulo, Sandra Albanese, Rosario Megna

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Rodent models of cerebral ischemia provide a valuable contribution to better understanding stroke pathophysiology, validate diagnostic methods, and enable testing new treatments for ischemia-reperfusion damage comorbidities. However, ethical concerns have led increased attention the welfare aspects such models. Supportive therapies are an essential part overall animal care use program should be tailored experimental model being studied, regulatory requirements, research objectives achieve high-quality preclinical studies practices. On other hand, veterinary medical in must balance needs potential sources bias results. This report provides systematic review scientific literature covering relevant period from years 1988 September 2024, with aim investigating interventions useful minimize suffering rodent without producing bias. The findings, consolidated 181 selected studies, published 1991 2023, indicate feasibility implementing personalized protocols anesthesia, analgesics, antibiotics, supportive stroke, while avoiding interferences. These data fill gap current knowledge could interest interdisciplinary audience working stimulating further refinements safeguard both validity may promote culture conduct various fields disciplines.

Language: Английский

Citations

0
Neuro-nutraceuticals: Emerging molecular and functional insights into how natural products improve brain health DOI
Kochupurackal P. Mohanakumar, Catarina Rendeiro, Philip M. Beart

et al.

Neurochemistry International, Journal Year: 2025, Volume and Issue: unknown, P. 105948 - 105948

Published: Feb. 1, 2025

Language: Английский

Citations

0
Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review DOI Creative Commons
Srikanth Yalabaka,

Dontiboina Harikrishna Reddy,

Vinjavarapu Lakshmi Anusha

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(5), P. 827 - 827

Published: March 6, 2025

Cruciferae family vegetables are remarkably high in phytochemicals such as Indole-3-carbinol (I3C) and Diindolylmethane (DIM), which widely known nutritional supplements. I3C DIM have been studied extensively different types of cancers like breast, prostate, endometrial, colorectal, gallbladder, hepatic, cervical, well other tissues. In this review, we summarized the protective effects against cardiovascular, neurological, reproductive, metabolic, bone, respiratory, liver, immune diseases, infections, drug- radiation-induced toxicities. Experimental evidence suggests that offer protection due to their antioxidant, anti-inflammatory, antiapoptotic, immunomodulatory, xenobiotic properties. Apart from beneficial effects, present review also discusses possible toxicities reported various preclinical investigations. So far, most reports about diseases only studies; emphasizes dire need for large-scale clinical trials on these human diseases. Further, in-depth research is required improve bioavailability two achieve desirable effects. Overall, our may become potential drug candidates combating dreadful

Language: Английский

Citations

0
Can the Atherogenic Index of Plasma (AIP) Be a Prognostic Marker for Good Clinical Outcome After Mechanical Thrombectomy for Acute Ischemic Stroke? DOI Creative Commons
Sena Boncuk Ulaş, Türkan Acar, Halil Alper Eryılmaz

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(8), P. 947 - 947

Published: April 8, 2025

Background: Stroke remains a leading cause of morbidity and mortality worldwide, with dyslipidemia playing crucial role in atherosclerosis stroke development. The Atherogenic Index Plasma (AIP), calculated as log(triglyceride/HDL), has emerged biomarker for cardiovascular risk. However, its relationship prognosis unclear. This study aimed to investigate the association between AIP favorable clinical outcomes at three months acute ischemic patients undergoing mechanical thrombectomy. Methods: We conducted retrospective analysis 222 who underwent thrombectomy December 2019 April 2023. demographic variables, etiology, successful recanalization, intracerebral hemorrhage, three-month mRS was evaluated. values were compared good (mRS 0–2) poor 3–6) outcomes. Results: most common comorbidity hypertension (72.1%), followed by AF (50%). etiologies included large artery (16.2%), cardioembolism (57.2%), undetermined causes (26.6%). significantly lower functional Additionally, inversely associated but positively correlated DM previous history. No significant observed recanalization or hemorrhage. Conclusions: is first demonstrate that elevated after Given strong correlation prognosis, may serve valuable identifying high-risk patients. Future prospective studies are needed further validate these findings explore potential management.

Language: Английский

Citations

0