Terbinafine for prostate cancer: development of coated zein nanospheres for ameliorated pro-apoptosis in PC3 cells DOI
Majid Mohammad Al-Sawahli,

Yasmin A. El-Feky,

Ahmed J. Mohammed

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 2, 2025

The purpose of this study was to investigate comparatively the anticancer potential Terbinafine loaded Dextran Sulphate coated Zein nanospheres against human prostate cancer PC3 cells enhance repurposing profile terbinafine utilizing optimized nano-sized delivery systems. formula fabricated using thin film hydration technique. Particle size analysis, drug diffusion, and encapsulation efficiency were considered when evaluating formula, which developed a Box-Behnken statistical design. Due optimization, mean particle 273.2 ± 1.98 nm, zeta -38.4 2.77 mV, amount released after 36 h 97.4 5.7%. exhibited significantly reduced IC50 in by around 14-fold. A higher cellular uptake observed. cell cycle assay results obtained suppression proliferation, especially G0/G1 S phases. This pro-apoptotic pattern confirmed increased mRNA expression CASP3 P53 CDK1, CDK7, CDK9. Furthermore, production reactive oxygen species achieved. revealed enhanced pro-apoptosis support toward cancer.

Language: Английский

Elucidating the anti-inflammatory potential of nanoscaled polymeric-albumin blends of garcinol: Optimization, in silico, in vitro, and in vivo studies DOI

Shayeri Chatterjee Ganguly,

Soumya Ganguly,

Beduin Mahanti

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 303, P. 140469 - 140469

Published: Feb. 1, 2025

Language: Английский

Citations

0
Neuro-nutraceuticals: Emerging molecular and functional insights into how natural products improve brain health DOI
Kochupurackal P. Mohanakumar, Catarina Rendeiro, Philip M. Beart

et al.

Neurochemistry International, Journal Year: 2025, Volume and Issue: unknown, P. 105948 - 105948

Published: Feb. 1, 2025

Language: Английский

Citations

0
Terbinafine for prostate cancer: development of coated zein nanospheres for ameliorated pro-apoptosis in PC3 cells DOI
Majid Mohammad Al-Sawahli,

Yasmin A. El-Feky,

Ahmed J. Mohammed

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 2, 2025

The purpose of this study was to investigate comparatively the anticancer potential Terbinafine loaded Dextran Sulphate coated Zein nanospheres against human prostate cancer PC3 cells enhance repurposing profile terbinafine utilizing optimized nano-sized delivery systems. formula fabricated using thin film hydration technique. Particle size analysis, drug diffusion, and encapsulation efficiency were considered when evaluating formula, which developed a Box-Behnken statistical design. Due optimization, mean particle 273.2 ± 1.98 nm, zeta -38.4 2.77 mV, amount released after 36 h 97.4 5.7%. exhibited significantly reduced IC50 in by around 14-fold. A higher cellular uptake observed. cell cycle assay results obtained suppression proliferation, especially G0/G1 S phases. This pro-apoptotic pattern confirmed increased mRNA expression CASP3 P53 CDK1, CDK7, CDK9. Furthermore, production reactive oxygen species achieved. revealed enhanced pro-apoptosis support toward cancer.

Language: Английский

Citations

0