Offline ensemble co-reactivation links memories across days

Nature, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Memories are encoded in neural ensembles during learning 1–6 and stabilized by post-learning reactivation 7–17 . Integrating recent experiences into existing memories ensures that contain the most recently available information, but how brain accomplishes this critical process remains unclear. Here we show mice, a strong aversive experience drives offline ensemble of not only memory also neutral formed 2 days before, linking fear to previous memory. Fear specifically links retrospectively, prospectively, across days. Consistent with studies, find is reactivated period after learning. However, increases co-reactivation period. Ensemble occurs more wake than sleep. Finally, expression context associated shared between memories. Collectively, these results demonstrate mechanism which integrated

Language: Английский

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Prefrontal coding of learned and inferred knowledge during REM and NREM sleep

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 24, 2024

Idling brain activity has been proposed to facilitate inference, insight, and innovative problem-solving. However, it remains unclear how when the idling can create novel ideas. Here, we show that cortical offline is both necessary sufficient for building unlearned inferential knowledge from previously acquired information. In a transitive inference paradigm, male C57BL/6J mice gained 1 day after, but not shortly complete training. Inhibiting neuronal computations in anterior cingulate cortex (ACC) during post-learning either non-rapid eye movement (NREM) or rapid (REM) sleep, wakefulness, disrupted without affecting learned knowledge. vivo Ca

Language: Английский

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Engram mechanisms of memory linking and identity

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(6), P. 375 - 392

Published: April 25, 2024

Language: Английский

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Aversive experience drives offline ensemble reactivation to link memories across days

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 14, 2023

Abstract Memories are encoded in neural ensembles during learning and stabilized by post-learning reactivation. Integrating recent experiences into existing memories ensures that contain the most recently available information, but how brain accomplishes this critical process remains unknown. Here we show mice, a strong aversive experience drives offline ensemble reactivation of not only memory also neutral formed two days prior, linking fear from to previous memory. We find specifically links retrospectively, prospectively, across days. Consistent with prior studies, period following learning. However, increases co-reactivation period. Finally, expression context is associated shared between memories. Taken together, these results demonstrate can drive retrospective memory-linking through providing mechanism which be integrated

Language: Английский

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Exploring the memory: existing activity-dependent tools to tag and manipulate engram cells

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 8, 2024

The theory of engrams, proposed several years ago, is highly crucial to understanding the progress memory. Although it significantly contributes identifying new treatments for cognitive disorders, limited by a lack technology. Several scientists have attempted validate this but failed. With increasing availability activity-dependent tools, researchers found traces engram cells. Activity-dependent tools are based on mechanisms underlying neuronal activity and use combination emerging molecular biological genetic Scientists used these tag manipulate neurons identified numerous internal connections between In review, we provide background, principles, selected examples applications existing tools. Using traditional definitions concepts cells, discuss limitations propose certain developmental directions further explore functions

Language: Английский

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Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration

Molecular Brain, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 23, 2025

Cognitive processes such as action planning and decision-making require the integration of multiple sensory modalities in response to temporal cues, yet underlying mechanism is not fully understood. Sleep has a crucial role for memory consolidation promoting cognitive flexibility. Our aim identify sleep integrating different enhance flexibility task execution while identifying specific brain regions that mediate this process. We have designed "Auditory-Gated Patience-to-Action" Task which mice should process auditory signals before well analyzing visual inputs feedback their action. Mice could learn rule apply it only after sleeping period keep performance constant across sessions. c-fos positive cells showed involvement prelimbic cortex (PrL) during execution. Chemo-genetic inhibition verified PrL required proper signal timing. These findings emphasize cortical activity are keys adapting modalities.

Language: Английский

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Enhancing and advancing the understanding and study of dreaming and memory consolidation: Reflections, challenges, theoretical clarity, and methodological considerations

Consciousness and Cognition, Journal Year: 2024, Volume and Issue: 123, P. 103719 - 103719

Published: June 27, 2024

Empirical investigations that search for a link between dreaming and sleep-dependent memory consolidation have focused on testing an association of what was learned, improved performance learned material. support this is mixed, perhaps owing to the inherent challenges presented by nature dreams, methodological inconsistencies. The purpose paper address critically prevalent assumptions practices, with aim clarifying enhancing research topic, chiefly providing theoretical synthesis existing models evidence. Also, it recommends method Targeted Memory Reactivation (TMR) as means investigating if dream content can be linked specific cued activations. Other recommendations enhance practice enquiry subject are also provided, focusing HOW WHY we sources in (if any) they might serve.

Language: Английский

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Prefrontal coding of learned and inferred knowledge during REM & NREM sleep

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: April 10, 2021

ABSTRACT Idling brain activity has been proposed to facilitate inference, insight, and innovative problem-solving 1-4 . However, it remains unclear how when the subconscious can create novel ideas. Here, we show coordinated roles of non-rapid eye movement (NREM) rapid-eye (REM) sleep in weaving inferential information from learned information. In a transitive inference paradigm, mice gained one day, but not shortly, after complete training. Inhibiting neuronal computations anterior cingulate cortex (ACC) during post-learning either NREM or REM sleep, wakefulness, disrupted without affecting knowledge. vivo Ca 2+ imaging showed gradual development inference-related representation, peaking at post-training sleep. Neurons representing co-reactivated significantly while their co-reactivation with neurons was higher Furthermore, insufficient learning, artificial activation medial entorhinal cortex-ACC dialogue only created These findings suggest that organizes scattered knowledge hierarchy, computes organized hierarchy. Collectively, our study provides mechanistic insight on coordination knowledge, thus highlighting power idling cognitive flexibility.

Language: Английский

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The Connection Between Mental Performance and Sleep

New Trends in Medicine Sciences, Journal Year: 2024, Volume and Issue: 5(2), P. 104 - 114

Published: May 27, 2024

Although our understanding of sleep physiology is growing, and many the mechanisms have been explained, studies focused on effect learning memory processes due to increase in after learning. However, it still unclear what kind information processing occurs brain during effects processing-related events are transferred from wakefulness sleep. Research suggests that has a positive impact function. whether specific stages, such as NREM REM, exclusively dedicated certain types memory, semantic or event memory. When evaluating research approaches discussed above, can be concluded important note limitations studying challenges conducting this state. Despite spending third lives asleep, benefits remains limited. It fact investigating phenomenon sleep, help us understand learning, consciousness, well function neurophysiology.

Language: Английский

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NSR special issue “The idling brain in cognition”

Neuroscience Research, Journal Year: 2023, Volume and Issue: 189, P. 1 - 2

Published: Feb. 23, 2023

Language: Английский

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