Annals of Neurology,
Journal Year:
2018,
Volume and Issue:
84(1), P. 23 - 36
Published: May 7, 2018
Chronic
systemic
inflammation
contributes
to
the
pathogenesis
of
many
age-related
diseases.
Although
not
well
understood,
alterations
in
gut
microbiota,
or
dysbiosis,
may
be
responsible
for
inflammation.Using
stroke
as
a
disease
model,
we
tested
hypothesis
that
youthful
when
established
aged
mice,
produces
positive
outcomes
following
ischemic
stroke.
Conversely,
an
young
negative
after
Young
and
male
mice
had
either
microbiota
by
fecal
transplant
gavage
(FTG).
Mice
were
subjected
(middle
cerebral
artery
occlusion;
MCAO)
sham
surgery.
During
subsequent
weeks,
underwent
behavioral
testing
samples
collected
16S
ribosomal
RNA
analysis
bacterial
content.We
found
is
altered
experimental
resembles
biome
uninjured
mice.
In
ratio
Firmicutes
Bacteroidetes
(F:B),
two
main
phyla
increased
∼9-fold
(p
<
0.001)
compared
young.
This
F:B
indicative
dysbiosis.
Altering
resemble
(∼6-fold
increase
ratio,
p
mortality
MCAO,
decreased
performance
testing,
cytokine
levels.
altering
(∼9-fold
decrease
survival
improved
recovery
MCAO.Aged
levels
proinflammatory
cytokines.
We
conclude
can
modified
positively
impact
from
Ann
Neurol
2018;83:23-36.
Translational Psychiatry,
Journal Year:
2019,
Volume and Issue:
9(1)
Published: Aug. 5, 2019
Abstract
Alzheimer’s
disease
(AD)
is
the
most
common
dementia
in
elderly.
Treatment
for
AD
still
a
difficult
task
clinic.
associated
with
abnormal
gut
microbiota.
However,
little
known
about
role
of
fecal
microbiota
transplantation
(FMT)
AD.
Here,
we
evaluated
efficacy
FMT
treatment
We
used
an
APPswe/PS1dE9
transgenic
(Tg)
mouse
model.
Cognitive
deficits,
brain
deposits
amyloid-β
(Aβ)
and
phosphorylation
tau,
synaptic
plasticity
as
well
neuroinflammation
were
assessed.
Gut
its
metabolites
short-chain
fatty
acids
(SCFAs)
analyzed
by
16S
rRNA
sequencing
1
H
nuclear
magnetic
resonance
(NMR).
Our
results
showed
that
could
improve
cognitive
deficits
reduce
deposition
mice.
These
improvements
accompanied
decreased
tau
protein
levels
Aβ40
Aβ42.
observed
increases
Tg
mice,
showing
postsynaptic
density
95
(PSD-95)
synapsin
I
expression
increased
after
FMT.
also
decrease
COX-2
CD11b
mice
found
reversed
changes
SCFAs.
Thus,
may
be
potential
therapeutic
strategy
Journal of Alzheimer s Disease,
Journal Year:
2017,
Volume and Issue:
60(4), P. 1241 - 1257
Published: Oct. 10, 2017
The
topic
of
gut
microbiota
is
currently
attracting
considerable
interest
as
a
potential
factor
in
Alzheimer's
disease
(AD).
However,
the
extent
and
time
course
alterations
microbiota,
their
effects
on
AD
pathology
remain
uncertain.
Herein,
we
compared
fecal
microbiomes
short
chain
fatty
acid
composition
(SCFAs)
between
wild-type
model
mice
at
different
ages
under
strictly
controlled
specific
pathogen
free
conditions,
also
conducted
microscopic
investigations
intestinal
structures.
Our
results
showed
that
diversity
were
perturbed
level
SCFAs
was
reduced
mice,
predicting
more
than
30
metabolic
pathways,
which
may
be
associated
with
amyloid
deposition
ultrastructural
abnormalities
mouse
intestine.
These
findings
indicate
might
not
only
affect
brain
function
directly,
but
exacerbate
cognitive
deficits
through
reducing
via
induced
by
deposition.
data
support
role
suggest
novel
route
for
therapeutic
intervention
AD.
Journal of Neuroinflammation,
Journal Year:
2019,
Volume and Issue:
16(1)
Published: May 22, 2019
Alzheimer's
disease
(AD)
is
a
neurodegenerative
whose
various
pathophysiological
aspects
are
still
being
investigated.
Recently,
it
has
been
hypothesized
that
AD
may
be
associated
with
dysbiosis
of
microbes
in
the
intestine.
In
fact,
intestinal
flora
able
to
influence
activity
brain
and
cause
its
dysfunctions.Given
growing
interest
this
topic,
purpose
review
analyze
role
antibiotics
relation
gut
microbiota
AD.
first
part
review,
we
briefly
theories
supporting
hypothesis
can
pathophysiology.
second
part,
possible
these
events.
Antibiotics
normally
used
remove
or
prevent
bacterial
colonization
human
body,
without
targeting
specific
types
bacteria.
As
result,
broad-spectrum
greatly
affect
composition
microbiota,
reduce
biodiversity,
delay
for
long
period
after
administration.
Thus,
action
could
wide
even
opposite,
depending
on
type
antibiotic
microbiome
pathogenesis.Alteration
induce
changes
activity,
which
raise
possibility
therapeutic
manipulation
other
neurological
disorders.
This
field
research
currently
undergoing
great
development,
but
applications
far
away.
Whether
achieved
using
not
known.
The
future
depends
progresses
We
must
understand
how
when
bacteria
act
promote
Once
well
established,
one
think
modifications
use
pre-,
pro-,
produce
effects.
Annals of Neurology,
Journal Year:
2018,
Volume and Issue:
84(1), P. 23 - 36
Published: May 7, 2018
Chronic
systemic
inflammation
contributes
to
the
pathogenesis
of
many
age-related
diseases.
Although
not
well
understood,
alterations
in
gut
microbiota,
or
dysbiosis,
may
be
responsible
for
inflammation.Using
stroke
as
a
disease
model,
we
tested
hypothesis
that
youthful
when
established
aged
mice,
produces
positive
outcomes
following
ischemic
stroke.
Conversely,
an
young
negative
after
Young
and
male
mice
had
either
microbiota
by
fecal
transplant
gavage
(FTG).
Mice
were
subjected
(middle
cerebral
artery
occlusion;
MCAO)
sham
surgery.
During
subsequent
weeks,
underwent
behavioral
testing
samples
collected
16S
ribosomal
RNA
analysis
bacterial
content.We
found
is
altered
experimental
resembles
biome
uninjured
mice.
In
ratio
Firmicutes
Bacteroidetes
(F:B),
two
main
phyla
increased
∼9-fold
(p
<
0.001)
compared
young.
This
F:B
indicative
dysbiosis.
Altering
resemble
(∼6-fold
increase
ratio,
p
mortality
MCAO,
decreased
performance
testing,
cytokine
levels.
altering
(∼9-fold
decrease
survival
improved
recovery
MCAO.Aged
levels
proinflammatory
cytokines.
We
conclude
can
modified
positively
impact
from
Ann
Neurol
2018;83:23-36.
