Default Mode Network Segregation Decreases in Healthy Brain Aging DOI
Abhijot S Sidhu,

Talal H. Shahid,

Kauê Tartarotti Nepomuceno Duarte

et al.

Published: Nov. 15, 2023

The default mode network (DMN) constitutes a cluster of interconnected brain regions engaged in internal cognitive processes, such as interoception, memory recall, and self-referential thinking. DMN is task-negative network, displaying increased activity during rest but reduced tasks. Resting-state functional magnetic resonance imaging (rs-MRI) examines this nature by tracking low-frequency fluctuations the blood oxygenation level-dependent signal an indirect marker for changes activity. Many cross-sectional studies have focused on understanding organization healthy aging, however, these fail to account intra-individual variance. To address limitation, we conducted longitudinal, pilot analysis that investigated segregation index ($SI$), simply defined ratio within-network connectivity relative between-network connectivity, across adult lifespan. Specifically, subset Calgary Normative Study data (67 individuals scanned twice over interval 3.1 ± 0.3 years, mean standard deviation) was analyzed. A linear mixed effects model used examine $Age,Age^{2}$, Sex, well Age $\times$ Sex interactions SI. We observed significant decline $SI$ with $\operatorname{Age}^{2}(t_{128}=-2.79,\ p\leq 0.001)$. Males demonstrated compared females $(t_{126}=-2.53,p=0.01$). By identifying $SI$, our study advances age-and sex-associated architecture, laying groundwork future work. In conclusion, confirms significance aging using longitudinal analysis. Using metric strengthened investigation combining within- into more robust reflects complex dynamic changes.

Language: Английский

The Human Cerebello-Hippocampal Circuit Across Adulthood DOI Open Access
Tracey H. Hicks, Thamires Naela Cardoso Magalhães, Jessica A. Bernard

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Direct communication between the hippocampus and cerebellum has been shown via coactivation synchronized neuronal oscillations in animal models. Further, this novel cerebello-hippocampal circuit may be impacted by sex steroid hormones. The are dense with estradiol progesterone receptors relative to other brain regions. Females experience up a 90% decrease ovarian production after menopausal transition. Postmenopausal women show lower cerebello-cortical intracerebellar FC compared reproductive aged females. Sex hormones established modulators of both memory function synaptic organization non-human studies. However, investigation (CB-HP) limited studies small homogeneous samples young adults as it relates spatial navigation. Here, we investigate CB-HP 138 adult humans (53% female) from 35-86 years age, define its patterns, associations behavior, hormone levels, differences therein. We robust patterns CB HP sample. predicted found negative relationships age FC. As expected, levels exhibited positive CB-HP. higher progesterone. provide first characterization across middle older adulthood demonstrate that connectivity is sensitive levels. This work provides clear mapping human serves foundation for future neurological psychiatric diseases.

Language: Английский

Citations

0
Altered cerebellar activation patterns in Alzheimer’s disease: An activation likelihood estimation Meta-Analysis DOI Creative Commons
Jessica A. Bernard,

Ivan A. Herrejon,

Emily An

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: unknown, P. 103770 - 103770

Published: March 1, 2025

The past decade has seen an increased interest in the cerebellum, particularly non-motor behaviors. Emerging work across model systems and humans also implicated cerebellum Alzheimer's Disease (AD) mild cognitive impairment (MCI). While is not as being central to etiology of disease, it however recognized increasingly important, most certainly immune from disease-related pathology atrophy. In cognitively normal older adults (OA), been conceptualized critical scaffolding for cortical function. This may extend AD MCI. With respect functional imaging, this largely unexplored AD, a nascent literature. there are very few studies focused on at stage, meta-analysis provides powerful tool expanding our knowledge neurodegenerative and, turn, hypothesis generation. We took advantage activation likelihood estimation (ALE) investigate overlap present existing but included exploratory analysis MCI, based papers available search. Our total 29 studies, representing data 236 individuals with 159 382 OA. Across these no significant cerebellar though Analyses group differences suggest that patterns indicative both greater reduced AD/MCI relative all findings, was primarily centered Crus I Lobule VI. These findings function negatively impacted which turn impact behavior symptomatology.

Language: Английский

Citations

0
Sex-steroid hormones relate to cerebellar structure and functional connectivity across adulthood DOI Creative Commons
Thamires Naela Cardoso Magalhães, Tracey H. Hicks, T. Bryan Jackson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Aging involves complex biological changes that affect disease susceptibility and aging trajectories. Although females typically live longer than males, they have a higher to diseases like Alzheimer's, speculated be influenced by menopause, reduced ovarian hormone production. Understanding sex-specific differences is crucial for personalized medical interventions gender equality in health. Our study aims elucidate sex regional cerebellar structure connectivity during normal investigating both structural functional variations, with focus on these the context of sex-steroid hormones. The included 138 participants (mean age = 57(13.3) years, range 35-86 54% women). cohort was divided into three groups: 38 early middle-aged individuals (EMA) 41(4.7) years), 48 late (LMA) 58(4) 42 older adults (OA) 72(6.3) years). All underwent MRI scans, saliva samples were collected quantification (17β-estradiol (E), progesterone (P), testosterone (T)). We found less between Lobule I-IV cuneus, greater Crus I, II, precuneus increased age. Higher 17β-estradiol levels linked I II subregions. Analyzing all together, associated lower respectively, while females. Structural observed, EMA males having larger volumes compared LMA OA groups, particularly right I-IV, V, VI. showed lobules V These results highlight significant role hormones modulating across adulthood, emphasizing need consider hormonal status neuroimaging studies better understand age-related cognitive decline neurological disorders.

Language: Английский

Citations

3
Severe menopausal symptoms linked to cognitive impairment: an exploratory study DOI

Andrés Calle,

Juan E. Blümel, Peter Chedraui

et al.

Menopause The Journal of The North American Menopause Society, Journal Year: 2024, Volume and Issue: 31(11), P. 959 - 965

Published: Aug. 13, 2024

To evaluate the association between menopausal symptoms and cognitive decline in postmenopausal women.

Language: Английский

Citations

3
Hormone-sleep interactions predict cerebellar connectivity and behavior in aging females DOI Creative Commons
Hannah K. Ballard, T. Bryan Jackson, Tracey H. Hicks

et al.

Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 150, P. 106034 - 106034

Published: Jan. 25, 2023

Language: Английский

Citations

7
Network segregation in aging females and evaluation of the impact of sex steroid hormones DOI Creative Commons
Tracey H. Hicks, Thamires Naela Cardoso Magalhães, Hannah K. Ballard

et al.

Frontiers in Human Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Feb. 1, 2023

Males and females show differential patterns in connectivity resting-state networks (RSNs) during normal aging, from early adulthood to late middle age. Age-related differences network integration (effectiveness of specialized communication at the global level) segregation (functional specialization local level specific brain regions) may also differ by sex. These be due least part endogenous hormonal fluctuation, such as that which occurs midlife with transition menopause when levels estrogens progesterone drop markedly. A limited number studies have investigated sex action steroid hormones networks. Here we how relate age-network relationships both males females, a focus on segregation. Females displayed significant quadratic relationship between age for cerebellar-basal ganglia salience In cases, was still increasing through adulthood, highest midlife, downturn thereafter. However, there were no hormone they did not exhibit associations or 17β-estradiol Patterns cerebellum basal been associated cognitive performance self-reported balance confidence older adults. Together, these findings suggest vary network, are this measure cross-sectional analysis. Though is null effect, it remains critical understanding extent architecture.

Language: Английский

Citations

7
Cerebello-Hippocampal Interactions in the Human Brain: A New Pathway for Insights Into Aging DOI
Jessica A. Bernard

The Cerebellum, Journal Year: 2024, Volume and Issue: 23(5), P. 2130 - 2141

Published: March 4, 2024

Language: Английский

Citations

2
Age‐related differences in functional network segregation in the context of sex and reproductive stage DOI Creative Commons
Hannah K. Ballard, T. Bryan Jackson,

Abigail C. Symm

et al.

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 44(5), P. 1949 - 1963

Published: Dec. 21, 2022

Age is accompanied by differences in the organization of functional brain networks, which impact behavior adulthood. Functional networks become less segregated and more integrated with age. However, sex network segregation declines age are not well-understood. Further, context female reproductive stage relatively understudied, though unmasking such relationships would be informative for elucidating biological mechanisms that contribute to sex-specific aging. In current work, we used data from Cambridge Centre Ageing Neuroscience (Cam-CAN) repository evaluate resting-state as a product stage. Reproductive was categorized using Stages Aging Workshop (STRAW+10) criteria. Replicating prior investigated following networks: auditory, cerebellar-basal ganglia, cingulo-opercular task control, default mode, dorsal attention, fronto-parietal salience, sensory somatomotor mouth, hand, ventral visual. First, our results mirror findings previous work indicating lower increasing Second, when analyzing associations between within each separately, find qualitative females males. Finally, report significant effects on segregation, these likely driven Broadly, suggest impacts may important investigating across adulthood, further needed determine unique role menopause hormones aging females.

Language: Английский

Citations

9
New frontiers for the understanding of aging: the power and possibilities of studying the cerebellum DOI Creative Commons
Jessica A. Bernard,

Kaitlin M McOwen,

Angelina T Huynh

et al.

Current Opinion in Behavioral Sciences, Journal Year: 2023, Volume and Issue: 54, P. 101311 - 101311

Published: Sept. 21, 2023

Language: Английский

Citations

4
Relationships of functional connectivity of motor cortex, primary somatosensory cortex, and cerebellum to balance performance in middle-aged and older adults DOI Creative Commons
Ashwini Sansare, Thamires Naela Cardoso Magalhães, Jessica A. Bernard

et al.

Neurobiology of Aging, Journal Year: 2024, Volume and Issue: 147, P. 1 - 11

Published: Nov. 29, 2024

Language: Английский

Citations

1