Published: April 26, 2024
The overall health of the US population has been improving for last 100 years. People are living longer although healthcare disparities continue. By 2050, number adults over 40 with dementia is projected to increase from 5.2 million people 10.5 million, according Lancet published in January 2022. will be nearly tripling globally. Dementia an escalated cost healthcare, social welfare and emotional financial burdens caregivers.
Language: Английский
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Journal Year: 2025, Volume and Issue: 17(2)
Published: April 1, 2025
Abstract INTRODUCTION We investigated whether a composite measure of late‐midlife lifestyle was associated with (1) longitudinal brain changes and (2) cognitive when adjusting for these changes. METHODS used linear mixed models to examine the LIfestyle BRAin Health (LIBRA) index in tau, white matter hyperintensity, neurodegeneration, cognition were similar amyloid positive (A+; > 17 Centiloids) negative participants. RESULTS included 324 individuals from Wisconsin Registry Alzheimer's Prevention (39% apolipoprotein E [ APOE ] 4 carrier, 30% A+, prior baseline age 67 [50–75]). The LIBRA not biomarker trajectories or primary outcome trajectory. There inconsistent effects on secondary domain‐specific trajectories. In contrast, tau neurodegeneration strongly DISCUSSION age‐range disease‐range studied, did exhibit meaningful effect disease vascular accumulation consistently Highlights this age‐range, Effects lifestyle, if any, may take more time manifest.
Language: Английский
Citations
0
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: May 3, 2024
Abstract Gut microbiome composition has been associated with early preclinical Alzheimer’s disease (AD), as reflected by cerebrospinal fluid (CSF) amyloid beta pathology, and mild cognitive impairment (MCI). However, the presence of distinct microbiota across different stages not fully characterized. We profiled gut in 50 nondemented individuals 16S ribosomal RNA sequencing taxonomic profiles were compared between amyloid-based (amyloid-normal vs. amyloid-pathology) clinically- based (cognitively normal MCI) diagnosis groups using linear models (adjusted for sex, age diet). Elastic net regression model was used to assess discriminative performance amyloid-pathology MCI. Microbial diversity measures did differ groups. identified specific genera MCI such Oxalobacter, Marvinbryantia Escherichia-Shigella , mostly linked inflammation. Distinct found be unique Microbiota shown have a fairly good performance. Overall, we suggest stage AD MCI, which needs further explored.
Language: Английский
Citations
2
Published: April 26, 2024
The overall health of the US population has been improving for last 100 years. People are living longer although healthcare disparities continue. By 2050, number adults over 40 with dementia is projected to increase from 5.2 million people 10.5 million, according Lancet published in January 2022. will be nearly tripling globally. Dementia an escalated cost healthcare, social welfare and emotional financial burdens caregivers.
Language: Английский
Citations
0