Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review
Mary E Faulkner,
No information about this author
Zhaoyuan Gong,
No information about this author
Alex Guo
No information about this author
et al.
Journal of Neurochemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 8, 2024
Abstract
Myelin
water
fraction
(MWF)
imaging
has
emerged
as
a
promising
magnetic
resonance
(MRI)
biomarker
for
investigating
brain
function
and
composition.
This
comprehensive
review
synthesizes
the
current
state
of
knowledge
on
MWF
human
cerebral
aging,
neurodegenerative
diseases,
risk
factors
influencing
myelination.
The
databases
used
include
Web
Science,
Scopus,
Science
Direct,
PubMed.
We
begin
with
brief
discussion
theoretical
foundations
imaging,
including
its
basis
in
MR
physics
mathematical
modeling
underlying
calculation,
an
overview
most
adopted
MRI
methods
imaging.
Next,
we
delve
into
clinical
research
applications
that
have
been
explored
to
date,
highlighting
advantages
limitations.
Finally,
explore
potential
serve
predictive
neurological
disorders
identify
future
directions
optimizing
protocols
interpreting
various
contexts.
By
harnessing
power
may
gain
new
insights
health
disease
across
lifespan,
ultimately
informing
novel
diagnostic
therapeutic
strategies.
image
Language: Английский
Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence
Christina Stammen,
No information about this author
Javier Schneider Penate,
No information about this author
Dorothea Metzen
No information about this author
et al.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Abstract
White
matter
is
fundamental
for
efficient
and
accurate
information
transfer
throughout
the
human
brain
thus
crucial
intelligence.
Previous
studies
often
demonstrated
associations
between
fractional
anisotropy
(FA)
as
a
metric
of
white
“microstructural
integrity”
intelligence,
but
it
still
unclear,
whether
this
relation
due
to
greater
axon
density,
parallel,
homogenous
fiber
orientation
distributions,
or
myelination
since
all
these
measures
influence
FA.
Using
neurite
dispersion
density
imaging
(NODDI)
myelin
water
fraction
(MWF)
data,
we
analyzed
microstructural
architecture
intelligence
in
more
detail
sample
500
healthy
young
adults.
Furthermore,
were
interested
specific
indices
play
intermediary
roles
pathway
that
links
genetic
disposition
phenotype.
Thus,
conducted
first
time
mediation
analyses
investigating
(NDI),
(ODI),
MWF
64
tracts
mediate
effects
polygenic
scores
(PGS
GI
)
on
general
By
doing
so,
showed
NDI,
not
ODI
was
significantly
associated
with
NDI
six
mediated
variability
g
.
These
findings
are
step
forward
decoding
neurogenetic
underpinnings
they
identify
relates
variation
,
whereas
did
not.
Language: Английский
Synergistic effects of plasma S100B and MRI measures of cerebrovascular disease on cognition in older adults
GeroScience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
There
is
growing
interest
in
studying
vascular
contributions
to
cognitive
impairment
and
dementia
(VCID)
developing
biomarkers
identify
at-risk
individuals.
A
combination
of
biofluid
neuroimaging
markers
may
better
profile
early
stage
VCID
than
individual
measures.
Here,
we
tested
this
possibility
focusing
on
plasma
levels
S100
calcium-binding
protein
B
(S100B),
which
has
been
linked
with
blood–brain-barrier
(BBB)
integrity,
measures
assessing
BBB
function
(water
exchange
rate
across
the
(k
w
))
cerebral
small
vessel
disease
(white
matter
hyperintensities
(WMHs)).
total
74
older
adults
without
had
samples
collected
underwent
assessment.
subsample
data
including
diffusion
prepared
pseudo-continuous
arterial
spin
labeling
(DP-pCASL)
for
assessment
k
T2-weighted
fluid-attenuated
inversion
recovery
(FLAIR)
quantification
WMHs.
Results
indicated
that
higher
S100B
were
associated
poorer
episodic
memory
performance
(
β
=
−
.031,
SE
.008,
p
<
.001).
Moreover,
significant
interactions
observed
between
parietal
lobe
(interaction
.095,
.042,
.028)
deep
WMH
volume
.025,
.009,
.007)
memory.
Individuals
poorest
showed
both
high
either
low
or
increased
burden.
Taken
together,
our
results
provide
support
combined
use
study
VCID.
Language: Английский
The cognitive neuroscience and neurocognitive rehabilitation of dance
BMC Neuroscience,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Nov. 6, 2024
Abstract
Creative
movement,
in
the
form
of
music-
and
dance-based
exercise
rehabilitation,
can
serve
as
a
model
for
learning
memory,
visuospatial
orientation,
mental
imagery,
multimodal
sensory-motor
integration.
This
review
summarizes
advancement
cognitive
neuroscience
aimed
at
determining
processes
brain
structural
functional
correlates
involved
dance
or
creative
well
which
accompany
such
activities.
We
synthesize
evidence
use
cognitive,
motor,
cognitive-motor
function
dance’s
potential
application
neurological
therapy
neurorehabilitation.
Finally,
we
discuss
how
partnered
interaction
sensorimotor
integration
dance,
“dancing
robots”
could
shed
light
on
future
used
technology
mechanisms
benefit
from
Language: Английский
Brain perfusion alterations in patients and survivors of COVID‐19 infection using arterial spin labeling: A systematic review
Brain‐X,
Journal Year:
2024,
Volume and Issue:
2(3)
Published: Sept. 1, 2024
Abstract
Coronavirus
disease
(COVID‐19)
has
been
shown
to
impact
the
central
nervous
system,
leading
various
neurological
complications.
Arterial
spin
labeling
(ASL),
a
non‐invasive
magnetic
resonance
imaging
technique,
enables
measurement
of
cerebral
blood
flow
and
perfusion
abnormalities.
This
systematic
review
aims
synthesize
ASL
findings
in
patients
with
COVID‐19
assess
potential
role
diagnosing
managing
A
comprehensive
search
was
conducted
on
PubMed
Scopus
for
studies
related
individuals
or
post‐COVID‐19
syndrome
published
between
December
2019
August
2024.
Extracted
data
encompassed
study
characteristics,
protocols,
cognitive
assessments,
principal
findings.
The
most
consistent
observation
across
hypoperfusion
detected
brain
regions,
particularly
within
frontal
lobes,
which
may
correlate
impairment
olfactory
dysfunction.
Additionally,
some
investigations
reported
hyperperfusion
localized
leptomeninges.
These
results
reflect
underlying
mechanisms
such
as
hypoxic–ischemic
injury,
inflammation,
vascular
dysfunction,
neuronal
damage
attributable
COVID‐19.
In
conclusion,
emerged
valuable
tool
evaluating
among
affected
by
recovering
from
since
it
offers
critical
insights
into
hemodynamics
metabolism.
Further
research
is
warranted
validate
these
elucidate
whether
contributes
persistent
issues.
Language: Английский