Brain perfusion alterations in patients and survivors of COVID‐19 infection using arterial spin labeling: A systematic review DOI Creative Commons
Sana Mohammadi, Sadegh Ghaderi, Farzad Fatehi

et al.

Brain‐X, Journal Year: 2024, Volume and Issue: 2(3)

Published: Sept. 1, 2024

Abstract Coronavirus disease (COVID‐19) has been shown to impact the central nervous system, leading various neurological complications. Arterial spin labeling (ASL), a non‐invasive magnetic resonance imaging technique, enables measurement of cerebral blood flow and perfusion abnormalities. This systematic review aims synthesize ASL findings in patients with COVID‐19 assess potential role diagnosing managing A comprehensive search was conducted on PubMed Scopus for studies related individuals or post‐COVID‐19 syndrome published between December 2019 August 2024. Extracted data encompassed study characteristics, protocols, cognitive assessments, principal findings. The most consistent observation across hypoperfusion detected brain regions, particularly within frontal lobes, which may correlate impairment olfactory dysfunction. Additionally, some investigations reported hyperperfusion localized leptomeninges. These results reflect underlying mechanisms such as hypoxic–ischemic injury, inflammation, vascular dysfunction, neuronal damage attributable COVID‐19. In conclusion, emerged valuable tool evaluating among affected by recovering from since it offers critical insights into hemodynamics metabolism. Further research is warranted validate these elucidate whether contributes persistent issues.

Language: Английский

Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review DOI Creative Commons

Mary E Faulkner,

Zhaoyuan Gong,

Alex Guo

et al.

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

Abstract Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance (MRI) biomarker for investigating brain function and composition. This comprehensive review synthesizes the current state of knowledge on MWF human cerebral aging, neurodegenerative diseases, risk factors influencing myelination. The databases used include Web Science, Scopus, Science Direct, PubMed. We begin with brief discussion theoretical foundations imaging, including its basis in MR physics mathematical modeling underlying calculation, an overview most adopted MRI methods imaging. Next, we delve into clinical research applications that have been explored to date, highlighting advantages limitations. Finally, explore potential serve predictive neurological disorders identify future directions optimizing protocols interpreting various contexts. By harnessing power may gain new insights health disease across lifespan, ultimately informing novel diagnostic therapeutic strategies. image

Language: Английский

Citations

9
Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence DOI Open Access

Christina Stammen,

Javier Schneider Penate,

Dorothea Metzen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Abstract White matter is fundamental for efficient and accurate information transfer throughout the human brain thus crucial intelligence. Previous studies often demonstrated associations between fractional anisotropy (FA) as a metric of white “microstructural integrity” intelligence, but it still unclear, whether this relation due to greater axon density, parallel, homogenous fiber orientation distributions, or myelination since all these measures influence FA. Using neurite dispersion density imaging (NODDI) myelin water fraction (MWF) data, we analyzed microstructural architecture intelligence in more detail sample 500 healthy young adults. Furthermore, were interested specific indices play intermediary roles pathway that links genetic disposition phenotype. Thus, conducted first time mediation analyses investigating (NDI), (ODI), MWF 64 tracts mediate effects polygenic scores (PGS GI ) on general By doing so, showed NDI, not ODI was significantly associated with NDI six mediated variability g . These findings are step forward decoding neurogenetic underpinnings they identify relates variation , whereas did not.

Language: Английский

Citations

0
Synergistic effects of plasma S100B and MRI measures of cerebrovascular disease on cognition in older adults DOI Creative Commons
Colleen Pappas, Christopher E. Bauer, Valentinos Zachariou

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract There is growing interest in studying vascular contributions to cognitive impairment and dementia (VCID) developing biomarkers identify at-risk individuals. A combination of biofluid neuroimaging markers may better profile early stage VCID than individual measures. Here, we tested this possibility focusing on plasma levels S100 calcium-binding protein B (S100B), which has been linked with blood–brain-barrier (BBB) integrity, measures assessing BBB function (water exchange rate across the (k w )) cerebral small vessel disease (white matter hyperintensities (WMHs)). total 74 older adults without had samples collected underwent assessment. subsample data including diffusion prepared pseudo-continuous arterial spin labeling (DP-pCASL) for assessment k T2-weighted fluid-attenuated inversion recovery (FLAIR) quantification WMHs. Results indicated that higher S100B were associated poorer episodic memory performance ( β = − .031, SE .008, p < .001). Moreover, significant interactions observed between parietal lobe (interaction .095, .042, .028) deep WMH volume .025, .009, .007) memory. Individuals poorest showed both high either low or increased burden. Taken together, our results provide support combined use study VCID.

Language: Английский

Citations

0
The cognitive neuroscience and neurocognitive rehabilitation of dance DOI Creative Commons
Madeleine E. Hackney,

Agnieszka Z. Burzynska,

Lena H. Ting

et al.

BMC Neuroscience, Journal Year: 2024, Volume and Issue: 25(1)

Published: Nov. 6, 2024

Abstract Creative movement, in the form of music- and dance-based exercise rehabilitation, can serve as a model for learning memory, visuospatial orientation, mental imagery, multimodal sensory-motor integration. This review summarizes advancement cognitive neuroscience aimed at determining processes brain structural functional correlates involved dance or creative well which accompany such activities. We synthesize evidence use cognitive, motor, cognitive-motor function dance’s potential application neurological therapy neurorehabilitation. Finally, we discuss how partnered interaction sensorimotor integration dance, “dancing robots” could shed light on future used technology mechanisms benefit from

Language: Английский

Citations

1
Brain perfusion alterations in patients and survivors of COVID‐19 infection using arterial spin labeling: A systematic review DOI Creative Commons
Sana Mohammadi, Sadegh Ghaderi, Farzad Fatehi

et al.

Brain‐X, Journal Year: 2024, Volume and Issue: 2(3)

Published: Sept. 1, 2024

Abstract Coronavirus disease (COVID‐19) has been shown to impact the central nervous system, leading various neurological complications. Arterial spin labeling (ASL), a non‐invasive magnetic resonance imaging technique, enables measurement of cerebral blood flow and perfusion abnormalities. This systematic review aims synthesize ASL findings in patients with COVID‐19 assess potential role diagnosing managing A comprehensive search was conducted on PubMed Scopus for studies related individuals or post‐COVID‐19 syndrome published between December 2019 August 2024. Extracted data encompassed study characteristics, protocols, cognitive assessments, principal findings. The most consistent observation across hypoperfusion detected brain regions, particularly within frontal lobes, which may correlate impairment olfactory dysfunction. Additionally, some investigations reported hyperperfusion localized leptomeninges. These results reflect underlying mechanisms such as hypoxic–ischemic injury, inflammation, vascular dysfunction, neuronal damage attributable COVID‐19. In conclusion, emerged valuable tool evaluating among affected by recovering from since it offers critical insights into hemodynamics metabolism. Further research is warranted validate these elucidate whether contributes persistent issues.

Language: Английский

Citations

0