Thalamic iron in multiple sclerosis: Waning support for the early-rise late-decline hypothesis
NeuroImage Clinical,
Journal Year:
2025,
Volume and Issue:
unknown, P. 103771 - 103771
Published: March 1, 2025
Studies
of
thalamic
iron
levels
in
multiple
sclerosis
(MS)
have
yielded
variable
findings,
potentially
due
to
differences
study
cohorts.
For
example,
studies
relatively
young
cohorts
(average
ages
below
40
years)
reported
elevated
susceptibility
people
with
MS
(pwMS),
whereas
older
(above
found
decreased
susceptibility.
To
test
the
"early-rise
late-decline"
hypothesis,
which
posits
that
age
are
responsible
for
conflicting
findings
regarding
MS.
We
chose
replicate
one
previous
showed
evidence
concentrations
younger
pwMS
(Rudko
et
al.,
2014).
also
replicated
a
involving
(Pudlac
2020)
serve
as
control.
assessed
using
QSM
processing
and
analysis
methodology
outlined
by
Rudko
al.
RESULTS:
Although
cohort
characteristics,
processing,
analytical
methods
were
closely
matched,
we
significantly
lower
compared
controls
(-1.1
±
7.8
vs.
5.4
6.1
ppb;
effect
sizes:
-0.35
-0.91).
Study
outcomes
robust
across
wide
range
regularization
parameters,
size
influenced
background
field
removal
regularization.
A
similar
pattern
was
observed
cohort,
where
again
(4.0
9.5
9.6
10.7
size:
-0.55).
Our
contradict
"early
rise"
hypothesis
pwMS.
The
consistency
our
results
analyses
suggests
artifacts
unlikely
explain
reports
increased
iron.
Instead,
these
variations
may
stem
from
demographic
or
clinical
differences,
such
geographical
factors
treatment
regimens.
Language: Английский
A Review of the Association Between Dietary Intake and Brain Iron Levels in Older Adults: Preliminary Findings and Future Directions
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4193 - 4193
Published: Dec. 4, 2024
Non-heme
iron
is
essential
for
critical
neuronal
functions
such
as
ATP
generation,
synaptogenesis,
neurotransmitter
synthesis,
and
myelin
formation.
However,
non-heme
accumulates
with
age,
excessive
levels
can
contribute
to
oxidative
stress,
potentially
disrupting
integrity
contributing
cognitive
decline.
Despite
growing
evidence
linking
high
brain
poorer
performance,
there
are
currently
no
proven
methods
reduce
accumulation
in
aging
or
protect
function
from
iron's
negative
effects.
Recent
studies
suggest
that
nutrition
may
influence
levels,
though
the
remains
limited
mixed.
Language: Английский