Biomarkers of blood–brain barrier and neurovascular unit integrity in human cognitive impairment and dementia DOI Creative Commons
Scott French,

B Meyer,

Juan Carlos Arias

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Abstract Blood–brain barrier (BBB) dysfunction is recognized as an early step in the development of Alzheimer's disease and related dementias (ADRD). Biomarkers are needed to monitor BBB integrity over time, better understand role neurodegeneration, potentially help define long‐term ADRD risk, effects therapeutics. In this review, we discuss current biomarkers used detect human context cognitive decline dementia. We also promising candidate fluid blood. Highlights permeability occurs during normal aging further exacerbated ADRD. vivo imaging CSF currently setting humans. review blood‐based that may represent dysfunction.

Language: Английский

Biomarkers of blood–brain barrier and neurovascular unit integrity in human cognitive impairment and dementia DOI Creative Commons
Scott French,

B Meyer,

Juan Carlos Arias

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Abstract Blood–brain barrier (BBB) dysfunction is recognized as an early step in the development of Alzheimer's disease and related dementias (ADRD). Biomarkers are needed to monitor BBB integrity over time, better understand role neurodegeneration, potentially help define long‐term ADRD risk, effects therapeutics. In this review, we discuss current biomarkers used detect human context cognitive decline dementia. We also promising candidate fluid blood. Highlights permeability occurs during normal aging further exacerbated ADRD. vivo imaging CSF currently setting humans. review blood‐based that may represent dysfunction.

Language: Английский

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