Reviews in Endocrine and Metabolic Disorders,
Journal Year:
2021,
Volume and Issue:
23(4), P. 753 - 772
Published: Dec. 4, 2021
Abstract
The
prefrontal
cortex
is
appreciated
as
a
key
neurobiological
player
in
human
eating
behavior.
A
special
focus
herein
dedicated
to
the
dorsolateral
(DLPFC),
which
critically
involved
executive
function
such
cognitive
control
over
eating.
Persons
with
obesity
display
hypoactivity
this
brain
area,
linked
overconsumption
and
food
craving.
Contrary
that,
higher
activity
DLPFC
associated
successful
weight-loss
weight-maintenance.
Transcranial
direct
current
stimulation
(tDCS)
non-invasive
neurostimulation
tool
used
enhance
self-control
inhibitory
control.
number
of
studies
using
tDCS
influence
behavior
rapidly
increased
last
years.
However,
effectiveness
still
unclear,
show
mixed
results
individual
differences
were
shown
be
an
important
factor
stimulation.
Here,
we
describe
state
research
intake,
craving,
subjective
feeling
hunger
body
weight.
Excitatory
right
seems
most
promising
reduce
cravings
highly
palatable
food,
while
other
provide
evidence
that
stimulating
left
shows
effects
on
weight
loss
maintenance,
especially
multisession
approaches.
Overall,
reported
findings
are
heterogeneous
pointing
large
interindividual
responsiveness.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 18, 2024
Abstract
The
hypothalamus
is
the
key
regulator
for
energy
homeostasis
and
functionally
connected
to
striatal
cortical
regions
vital
inhibitory
control
of
appetite.
Hence,
ability
non-invasively
modulate
network
could
open
new
ways
treatment
metabolic
diseases.
Here,
we
tested
a
novel
method
network-targeted
transcranial
direct
current
stimulation
(net-tDCS)
influence
excitability
brain
involved
in
Based
on
resting-state
functional
connectivity
map
hypothalamus,
12-channel
net-tDCS
protocol
was
generated
(Neuroelectrics
Starstim
system),
which
included
anodal,
cathodal
sham
stimulation.
Ten
participants
with
overweight
or
obesity
were
enrolled
sham-controlled,
crossover
study.
During
control,
completed
stop-signal
task
measure
control.
Overall,
well
tolerated.
Anodal
resulted
faster
stop
signal
reaction
time
(SSRT)
compared
(
p
=
0.039)
0.042).
Baseline
target
correlated
SSRT
after
anodal
0.016).
These
preliminary
data
indicate
that
modulating
via
may
result
improved
Further
studies
need
evaluate
effects
eating
behavior
metabolism.
Psychosomatic Medicine,
Journal Year:
2019,
Volume and Issue:
82(3), P. 261 - 271
Published: Dec. 3, 2019
Obesity
is
associated
with
differences
in
task-evoked
and
resting-state
functional
brain
connectivity
(FC).
However,
no
studies
have
compared
obesity-related
FC
evoked
by
high-calorie
food
cues
from
that
observed
at
rest.
Such
a
comparison
could
improve
our
understanding
of
the
neural
mechanisms
reward
valuation
decision
making
context
obesity.The
sample
included
122
adults
(78%
female;
mean
age
=
44.43
[8.67]
years)
body
mass
index
(BMI)
overweight
or
obese
range
(mean
31.28
[3.92]
kg/m).
Participants
completed
magnetic
resonance
imaging
scan
resting
period
followed
visual
cue
task.
Whole-brain
analyses
examined
seed-to-voxel
signal
covariation
during
presentation
rest
using
seeds
located
left
right
orbitofrontal
cortex,
hippocampus,
dorsomedial
prefrontal
cortex.For
all
examined,
BMI
was
stronger
food,
but
weaker
Regions
exhibiting
BMI-related
modulation
coherence
presence
palatable
were
largely
within
default
mode
network
(z
2.34-4.91),
whereas
regions
frontostriatal
networks
3.05-4.11).
All
results
exceeded
voxelwise
threshold
p
<
.01
cluster-defining
familywise
error
.05.These
dissociable
patterns
may
suggest
separate
contributing
to
variation
distinct
cognitive,
psychological,
behavioral
domains
be
related
individual
risk
for
obesity.
Reviews in Endocrine and Metabolic Disorders,
Journal Year:
2021,
Volume and Issue:
23(4), P. 753 - 772
Published: Dec. 4, 2021
Abstract
The
prefrontal
cortex
is
appreciated
as
a
key
neurobiological
player
in
human
eating
behavior.
A
special
focus
herein
dedicated
to
the
dorsolateral
(DLPFC),
which
critically
involved
executive
function
such
cognitive
control
over
eating.
Persons
with
obesity
display
hypoactivity
this
brain
area,
linked
overconsumption
and
food
craving.
Contrary
that,
higher
activity
DLPFC
associated
successful
weight-loss
weight-maintenance.
Transcranial
direct
current
stimulation
(tDCS)
non-invasive
neurostimulation
tool
used
enhance
self-control
inhibitory
control.
number
of
studies
using
tDCS
influence
behavior
rapidly
increased
last
years.
However,
effectiveness
still
unclear,
show
mixed
results
individual
differences
were
shown
be
an
important
factor
stimulation.
Here,
we
describe
state
research
intake,
craving,
subjective
feeling
hunger
body
weight.
Excitatory
right
seems
most
promising
reduce
cravings
highly
palatable
food,
while
other
provide
evidence
that
stimulating
left
shows
effects
on
weight
loss
maintenance,
especially
multisession
approaches.
Overall,
reported
findings
are
heterogeneous
pointing
large
interindividual
responsiveness.
