FEMA: Fast and efficient mixed‐effects algorithm for large sample whole‐brain imaging data

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(2)

Published: Jan. 29, 2024

Abstract The linear mixed‐effects model (LME) is a versatile approach to account for dependence among observations. Many large‐scale neuroimaging datasets with complex designs have increased the need LME; however LME has seldom been used in whole‐brain imaging analyses due its heavy computational requirements. In this paper, we introduce fast and efficient algorithm (FEMA) that makes vertex‐wise, voxel‐wise, connectome‐wide large samples possible. We validate FEMA extensive simulations, showing estimates of fixed effects are equivalent standard maximum likelihood but obtained orders magnitude improvement speed. demonstrate applicability by studying cross‐sectional longitudinal age on region‐of‐interest level vertex‐wise cortical thickness, as well functional connectivity values derived from resting state MRI, using data Adolescent Brain Cognitive Development SM Study release 4.0. Our reveal distinct spatial patterns annualized changes thickness early adolescence, highlighting critical time brain maturation. simulations application real show enables advanced investigation relationships between numbers metrics variables interest while considering study designs, including repeated measures family structures, manner. source code available via: https://github.com/cmig-research-group/cmig_tools/ .

Language: Английский

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Parental education and income are linked to offspring cortical brain structure and psychopathology at 9–11 years

JCPP Advances, Journal Year: 2024, Volume and Issue: 4(1)

Published: Feb. 6, 2024

A child's socioeconomic environment can shape central aspects of their life, including vulnerability to mental disorders. Negative environmental influences in youth may interfere with the extensive and dynamic brain development occurring at this time. Indeed, there are numerous yet diverging reports associations between parental status (SES) child cortical morphometry. Most these studies have used single metric- or unimodal analyses standard morphometry that downplay probable scenario where biological pathways

Language: Английский

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Too Much Heat May Make You Smoke

Global Journal of Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: 4(1), P. 1 - 10

Published: Jan. 15, 2025

Background: The rising concerns surrounding climate change have drawn attention to its potential impact on health, particularly among vulnerable groups such as children and older adults. Despite extensive research health consequences, limited studies explored the connection between extreme heat exposure tobacco use initiation adolescents in United States. Objectives: This study examines relationship of adolescents, using data from Adolescent Brain Cognitive Development (ABCD) study. It also evaluates mediating roles major depressive disorder (MDD) childhood behavioral problems. Methods: Data 11,878 participants ABCD were analyzed explore link (independent variable) (dependent variable). Covariates included age, sex, race/ethnicity, while MDD problems (measured Child Behavior Checklist, CBCL) assessed mediators. Structural equation modeling (SEM) was applied for analysis. Results: findings indicated a significant association an increased likelihood aged 9 15. partially mediated this relationship. Conclusions: These results underscore importance targeted interventions aimed at mitigating adolescent including influence initiation. Addressing mental challenges could help reduce these risks. Future longitudinal is needed confirm evaluate efficacy strategies protect youth populations.

Language: Английский

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Heat Exposure Predicts Earlier Childhood Pubertal Initiation, Behavioral Problems, and Tobacco Use

Global Journal of Epidemiology and Infectious Disease, Journal Year: 2025, Volume and Issue: 5(1), P. 1 - 11

Published: Jan. 16, 2025

Climate change has raised significant concerns about its impact on health, particularly for vulnerable populations such as children and adolescents. While extensive research examined physical health effects, limited attention been given to the influence of extreme heat developmental behavioral outcomes. This study investigates association between exposure early puberty initiation (ages 9-10), using data from Adolescent Brain Cognitive Development (ABCD) study. It further explores how correlates with problems tobacco use initiation. Data 11,878 participants in ABCD were analyzed examine relationship (independent variable) (outcome). Behavioral evaluated downstream outcomes puberty. Covariates included age, sex, race/ethnicity, assessed Child Behavior Checklist (CBCL). Structural equation modeling (SEM) was employed analysis. Extreme significantly associated earlier at ages 9-10. Early puberty, turn, correlated higher levels an increased likelihood These findings underscore importance addressing environmental factors reduce risks maturation, including substance challenges. Targeted interventions policies are needed mitigate child development, longitudinal studies essential confirm these results inform effective prevention strategies.

Language: Английский

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Extreme Heat Exposure and Adolescent Cognitive Function

Universal journal of neuroscience., Journal Year: 2025, Volume and Issue: 3(1), P. 1 - 9

Published: Jan. 16, 2025

Extreme heat exposure is an increasing public health concern, particularly in the context of climate change. Limited research has explored its impact on children's cognitive outcomes. This study investigates association between extreme and function 9-10-year-old children, using data from Adolescent Brain Cognitive Development (ABCD) study. Additionally, we assess whether this effect independent socio-demographic factors such as race, family socioeconomic status (SES), neighborhood SES. Data were drawn ABCD study, comprising over 10,000 children aged 9-10 years. was assessed through standardized tests, while estimated geographic data. Structural equation modeling (SEM) employed to examine direct effects outcomes account for potential confounding variables, including SES, Black families, low SES households, neighborhoods disproportionately exposed heat. significantly associated with lower remained robust even after adjusting factors. linked diminished among socio-economically disadvantaged marginalized populations. Given frequency events due change, future should further explore these implications Policy interventions that improve access cooling infrastructure, expand green spaces, prioritize at-risk populations are critical mitigating adverse communities.

Language: Английский

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Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study

Developmental Cognitive Neuroscience, Journal Year: 2021, Volume and Issue: 52, P. 101022 - 101022

Published: Oct. 19, 2021

Adversity exposure is a risk factor for psychopathology, which most frequently onsets during adolescence, and prior research has demonstrated that alterations in cortico-limbic connectivity may account part this association. In sample of youth from the Adolescent Brain Cognitive Development (ABCD) Study (N = 4006), we tested longitudinal structural equation model to examine indirect effect adversity (negative life events) on later psychopathology via changes resting-state functional (rsFC). We also examined potential protective effects parental acceptance. Generally, became more strongly negative between baseline year 2 follow-up, suggesting stronger correlations within these networks reflect mature phenotype. Exposure greater number events was associated with rsFC which, turn, lower internalizing (but not externalizing) symptoms. The symptoms significant. Parental acceptance did moderate association rsFC. Our findings highlight how stressful childhood experiences accelerate neurobiological maturation specific connections, potentially reflecting an adaptive process protects against problems context adversity.

Language: Английский

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Microstructural development from 9 to 14 years: Evidence from the ABCD Study

Developmental Cognitive Neuroscience, Journal Year: 2021, Volume and Issue: 53, P. 101044 - 101044

Published: Dec. 3, 2021

During late childhood behavioral changes, such as increased risk-taking and emotional reactivity, have been associated with the maturation of cortico-cortico cortico-subcortical circuits. Understanding microstructural changes in both white matter subcortical regions may aid our understanding how individual differences these behaviors emerge. Restriction spectrum imaging (RSI) is a framework for modelling diffusion-weighted that decomposes diffusion signal from voxel into hindered, restricted, free compartments. This yields greater specificity than conventional methods characterizing diffusion. Using RSI, we quantified voxelwise restricted across brain measured age associations large sample (n = 8086) Adolescent Brain Cognitive Development (ABCD) study aged 9-14 years. Older participants showed higher fraction brain, largest regions, particularly basal ganglia ventral diencephalon. Importantly, varied respect to cytoarchitecture within fiber tracts structures, example differed thalamic nuclei. suggests age-related map onto specific cell populations or circuits highlights utility compared ROI-wise analyses. Future analyses will aim understand relevance this developmental outcomes.

Language: Английский

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Responsible Use of Open-Access Developmental Data: The Adolescent Brain Cognitive Development (ABCD) Study

Psychological Science, Journal Year: 2021, Volume and Issue: 32(6), P. 866 - 870

Published: May 27, 2021

Language: Английский

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An update on the assessment of culture and environment in the ABCD Study®: Emerging literature and protocol updates over three measurement waves

Developmental Cognitive Neuroscience, Journal Year: 2021, Volume and Issue: 52, P. 101021 - 101021

Published: Oct. 19, 2021

Advances in our understanding of risk and resilience factors adolescent brain health development increasingly demand a broad set assessment tools that consider youth's peer, family, school, neighborhood, cultural contexts addition to neurobiological, genetic, biomedical information. The Culture Environment (CE) Workgroup (WG) the Adolescent Brain Cognitive Development (ABCD) Study curates these important components protocol throughout ten years planned data collection. In this report, CE WG presents an update on evolution ABCD Study® since study inception (Zucker et al., 2018), as well emerging findings include measures. Background measurement characteristics instruments present baseline have already been described 2018 therefore are only briefly here. New measures introduced more detail. Descriptive statistics all presented based total sample 11,000+ youth their caregivers assessed at following two years. Psychometric properties measures, including longitudinal aspects data, reported, along with considerations for future waves. ABCD® essential part overall permits characterization unique social environment within which each developing is transactionally embedded.

Language: Английский

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A history of previous childbirths is linked to women's white matter brain age in midlife and older age

Human Brain Mapping, Journal Year: 2021, Volume and Issue: 42(13), P. 4372 - 4386

Published: June 12, 2021

Maternal brain adaptations occur in response to pregnancy, but little is known about how parity impacts white matter and ageing trajectories later life. Utilising global regional age prediction based on multi-shell diffusion-weighted imaging data, we investigated the association between previous childbirths 8,895 women UK Biobank cohort (age range = 54-81 years). The results showed that number of was negatively associated with age, potentially indicating a protective effect Both grey estimates unique contributions childbirths, suggesting partly independent processes. Corpus callosum contributed uniquely stronger relationship relative several other tracts. While our findings demonstrate link reproductive history characteristics life, longitudinal studies are required establish causality determine may influence women's across lifespan.

Language: Английский

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