Transcutaneous auricular vagus nerve stimulation modulates the processing of interoceptive prediction error signals and their role in allostatic regulation

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(3)

Published: Feb. 15, 2024

It has recently been suggested that predictive processing principles may apply to interoception, defined as the of hormonal, autonomic, visceral, and immunological signals. In current study, we aimed at providing empirical evidence for role cardiac interoceptive prediction errors signals on allostatic adjustments, using transcutaneous auricular vagus nerve stimulation (taVNS) a tool modulate afferents. within-subject design, participants performed cardiac-related task (heartbeat counting task) under taVNS sham stimulation, spaced 1-week apart. We observed taVNS, in contrast facilitated maintenance accuracy levels over time (from initial, stimulation-free, baseline block subsequent blocks), suggesting have helped maintain engagement afferent During task, compared sham, produced higher heart-evoked potentials (HEP) amplitudes, potential readout measure error processing. Further analyses revealed positive relation between adjustments-as measured by heart rate variability (HRV)-was mediated HEP amplitudes. Providing initial support accounts our results suggest increase precision with which are processed, favoring their influence adjustments.

Language: Английский

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Attention to cardiac sensations enhances the heartbeat-evoked potential during exhalation

iScience, Journal Year: 2024, Volume and Issue: 27(4), P. 109586 - 109586

Published: March 27, 2024

Respiration and cardiac activity intricately interact through complex physiological mechanisms. The heartbeat-evoked potential (HEP) is an EEG fluctuation reflecting the cortical processing of signals. We recently found higher HEP amplitude during exhalation than inhalation a task involving attention to sensations. This may have been due reduced perception heightened attentional To investigate relationships between HEP, attention, respiration, we introduced experimental setup that included tasks related respiratory interoceptive exteroceptive attention. Results revealed increases over fronto-central electrodes. When phases were taken into account, primarily driven by heartbeats recorded exhalation, specifically task, while had minimal impact. These findings emphasize role respiration in could implications for interventions fine-tune interoception.

Language: Английский

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The effect of slow breathing in regulating anxiety

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 11, 2025

Abstract Anxiety is an interactive disorder of the mind and body, characterized by excessive worry about uncertain future events a dysfunction autonomic nervous system. Previous studies have shown that slow, deep breathing can reduce physical tension, anxiety. Although we know slow techniques effectively regulate anxiety other emotions, psychological neurophysiological mechanisms on not been systematically explored. In study, combined paced task with threat uncertainty for first time to investigate role in regulating Here investigated this question, using Spectral analysis Time-frequency domain EEG assess brain activity relating respiratory rate mechanism impact anxious. Twenty-seven individuals participated experiment, which followed 2 (respiratory rate: fast breathing, breathing) × (certainty: certain, uncertain) within-subjects design. The results showed that: (1) Slow reduced anxiety, valence arousal are lower under breathing. (2) different characteristics. There overall increase power during delta, theta, alpha beta bands.(3) interaction certainty were closely related beta. uncertain, decreased but increased

Language: Английский

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Respiratory sinus arrhythmia (RSA), vagal tone and biobehavioral integration: Beyond parasympathetic function

Biological Psychology, Journal Year: 2023, Volume and Issue: 186, P. 108739 - 108739

Published: Dec. 25, 2023

Linchpin to the entire area of psychophysiological research and discussion vagus is respiratory cardiovascular phenomenon known as sinus arrhythmia (RSA; often synonymous with high-frequency heart-rate variability when it specifically linked frequency), i.e. rhythmic fluctuations in heart rate synchronized inspiration expiration. This article aims 1) clarify concepts, terms measures commonly employed during last half century scientific literature, which relate vagal function psychological processes general aspects health; 2) expand upon an earlier theoretical model, emphasizing importance RSA well beyond current focus parasympathetic mechanisms. A close examination its relations may dispel certain held beliefs about associations between functioning, nervous system (for nerve plays a major role), offer fresh perspectives likely functions adaptive significance RSA, RSA's relationship control. neither invariably reliable index cardiac tone nor central outflow heart. The model here presented posits that represents evolutionarily entrenched, significantly contributes meeting continuously changing metabolic, energy behavioral demands.

Language: Английский

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Integrative neuro-cardiovascular dynamics in response to test anxiety: A brain-heart axis study

Physiology & Behavior, Journal Year: 2024, Volume and Issue: 276, P. 114460 - 114460

Published: Jan. 10, 2024

Test anxiety (TA), a recognized form of social anxiety, is the most prominent cause among students and, if left unmanaged, can escalate to psychiatric disorders. TA profoundly impacts both central and autonomic nervous systems, presenting as dual manifestation cognitive components. While limited studies have explored physiological underpinnings TA, none directly investigated intricate interplay between CNS ANS in this context. In study, we introduce non-invasive, integrated neuro-cardiovascular approach comprehensively characterize responses 27 healthy subjects subjected test induced via simulated exam scenario. Our experimental findings highlight that an isolated analysis electroencephalographic heart rate variability data fails capture information provided by brain-heart axis assessment, which incorporates dynamic interaction brain heart. With respect resting state, examination decrease neural control onto heartbeat dynamics at all frequencies, while studying condition ascending heart-to-brain EEG oscillations up 12Hz. This underscores significance adopting multisystem perspective understanding complex especially functional directional mechanisms underlying anxiety.

Language: Английский

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The impact of cardiac phases on multisensory integration

Biological Psychology, Journal Year: 2023, Volume and Issue: 182, P. 108642 - 108642

Published: July 18, 2023

The brain continuously processes information coming from both the external environment and visceral signals generated by body. This constant exchange between body allows originating oscillatory activity of heart, among others, to influence perception. Here, we investigated how cardiac phase modulates multisensory integration, which is process that multiple senses combine non-linearly reduce environmental uncertainty. Forty healthy participants completed a Simple Detection Task with unimodal (Auditory, Visual, Tactile) bimodal (Audio-Tactile, Audio-Visual, Visuo-Tactile) stimuli presented 250 ms 500 after R-peak electrocardiogram, is, systole diastole, respectively. First, found nonspecific effect cycle phases on detection stimuli. Reaction times were faster for during compared systole. Then, applying Race Model Inequality approach quantify Audio-Tactile Visuo-Tactile, but not Audio-Visual stimuli, showed higher integration when diastole than These findings indicate impact may be specific including somatosensory (i.e., tactile) inputs. suggests heartbeat-related noise, according interoceptive predictive coding theory suppresses inputs, also affects In conclusion, our data extend domain. From more mechanistic view, they reflect reduced optimization neural oscillations orchestrating

Language: Английский

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Time-varying information measures: an adaptive estimation of information storage with application to brain-heart interactions

Frontiers in Network Physiology, Journal Year: 2023, Volume and Issue: 3

Published: Oct. 18, 2023

Network Physiology is a rapidly growing field of study that aims to understand how physiological systems interact maintain health. Within the information theory framework storage (IS) allows measure regularity and predictability dynamic process under stationarity assumption. However, this assumption does not allow track over time transient pathways occurring in dynamical activity system. To address limitation, we propose time-varying approach based on recursive least squares algorithm (RLS) for estimating IS at each instant, non-stationary conditions. We tested simulated dynamics analysis electroencephalographic (EEG) signals recorded from healthy volunteers timed with heartbeat investigate brain-heart interactions. In simulations, show proposed both abrupt slow changes stored These are reflected its evolution variability time. The interactions reveals marked differences across cardiac cycle phases IS. On other hand, average values exhibit weak modulation parieto-occiptal areas scalp. Our highlights importance developing more advanced methods measuring account non-stationarity systems. RLS represents useful tool identifying spatio-temporal within neurocardiac system can contribute understanding

Language: Английский

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Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 30, 2022

Recent studies have established that cardiac and respiratory phases can modulate perception related neural dynamics. While heart rate sinus arrhythmia possibly affect interoception biomarkers, such as heartbeat-evoked potentials, the relative changes in cardiorespiratory dynamics interoceptive processes not yet been investigated. In this study, we investigated variation breathing rates, well higher functional including correlation frontal hemodynamics measured with fNIRS, during a heartbeat counting task. To further investigate physiology linked to vagal activity caused by specific performed task together controlled The results demonstrate focusing on heartbeats decreases rates comparison, which may be part of physiological mechanisms "listening" heart, focus attention, self-awareness. Focusing was also observed increase connectivity, supporting role structures monitoring visceral inputs. However, is affected both tasks. Based these results, concluded variations are confounding factors assessment abilities fluctuations should considered mode covariate measurement processes.

Language: Английский

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Pressure Pulsatility Links Cardio-Respiratory and Brain Rhythmicity

Journal of Integrative Neuroscience, Journal Year: 2023, Volume and Issue: 22(6)

Published: Oct. 23, 2023

This article presents evidence indicating that intracranial pressure (ICP) pulsatility, associated with the heartbeat and breathing, is not just a source of mechanical artefact in electrical recordings, but “sensed” plays role brain’s information processing. Patch-clamp recording pressure-activated channels, detection Piezo2-protein channel expression brain neurons, suggest these channels provide neurons an intrinsic resonance to ICP which acts synchronize remote neural networks. Direct measurements human patients indicate breathing rhythms generate forces tens millinewtons, exceeding by orders magnitude localized shown atomic force microscopy optical tweezers activate Piezo isolated neocortical hippocampal neurons. Additionally, many touch proprioceptors, are also transduced show spiking phase-locked heartbeat- breathing-induced extracranial pulsations. Finally, based on observation low-frequency oscillations modulate phase amplitude high-frequency oscillations, body proposed form single hierarchical system basic frequency scaling factor for all other oscillations. Together, results support idea pulsatility may be elemental modulating rhythmicity.

Language: Английский

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Heart is deceitful above all things: Threat expectancy induces the illusory perception of increased heartrate

Cognition, Journal Year: 2024, Volume and Issue: 245, P. 105719 - 105719

Published: Jan. 25, 2024

Language: Английский

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