Disrupted Hierarchical Functional Brain Organization in Affective and Psychotic Disorders: Insights from Functional Brain Gradients DOI
Joseph Kambeitz,

H. Häcker,

Linnea Hoheisel

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Patients with psychosis and depression show widespread alterations in brain resting-state functional connectivity (rs-FC), affecting both sensory higher-order regions. In this study, we investigate disruptions the hierarchical organization of networks patients psychotic affective disorders. We derived gradients, low dimensional representations rs-FC that capture cortical hierarchy, a large patient sample including clinical high-risk for (CHR-P) patients, recent-onset (ROP) (ROD) healthy controls (HC). examined regional alterations, network-level differentiation their relationship to symptoms. addition, linked case-control differences receptor expression maps explore underlying neurobiological mechanisms. All groups exhibited visual-to-sensorimotor gradient, while only ROP showed association-to-sensory gradient. CHR-P lower values ventral attention network. Additionally, combined higher somatomotor network, reduced gradient range altered between-network dispersion. ROD within-network dispersion attentional range. Correlational analysis revealed weak associations measures functioning, visual dysfunctions cognition. Furthermore maps, suggesting involvement neurotransmitter systems these disruptions. Our findings reveal transdiagnostic disease-specific organization. These indicate deficits integration across psychiatric diseases, highlighting role disease processes.

Language: Английский

From histology to macroscale function in the human amygdala DOI Creative Commons
Hans Auer, Donna Gift Cabalo, Raúl Rodríguez‐Cruces

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 4, 2025

The amygdala is a subcortical region in the mesiotemporal lobe that plays key role emotional and sensory functions. Conventional neuroimaging experiments treat this structure as single, uniform entity, but there ample histological evidence for subregional heterogeneity microstructure function. current study characterized structure-function coupling human amygdala, integrating post-mortem histology vivo MRI at ultra-high fields. Core to our work was novel neuroinformatics approach leveraged multiscale texture analysis well non-linear dimensionality reduction techniques identify salient dimensions of microstructural variation 3D reconstruction amygdala. We observed two axes region, describing inferior-superior mediolateral trends differentiation part recapitulated established atlases subnuclei. Translating data acquired 7 Tesla, we could demonstrate generalizability these spatial across 10 healthy adults. then cross-referenced with functional blood-oxygen-level dependent (BOLD) signal obtained during task-free conditions, revealed close association structural macroscale network embedding, notably temporo-limbic, default mode, sensory-motor networks. Our consolidates descriptions anatomy function from imaging techniques.

Language: Английский

Citations

0
ChatGPT-estimated occupational complexity predicts cognitive outcomes and cortical thickness above and beyond socioeconomic status among older adults DOI
Junhong Yu, Ee Heok Kua, Rathi Mahendran

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Language: Английский

Citations

0
Transcriptional substrates of cortical thickness alterations in anhedonia of major depressive disorder DOI
Sugai Liang, Yuan Gao, Lena Palaniyappan

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Atypical maturation of the functional connectome hierarchy in autism DOI Creative Commons
Jong‐Eun Lee,

Sunghun Kim,

Shinwon Park

et al.

Molecular Autism, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

Abstract Background Autism spectrum disorder (ASD) is marked by disruptions in low-level sensory processing and higher-order sociocognitive functions, suggesting a complex interplay between different brain regions across the cortical hierarchy. However, developmental trajectory of this hierarchical organization ASD remains underexplored. Herein, we investigated maturational abnormalities hierarchy among individuals with ASD. Methods Resting-state functional magnetic resonance imaging data from three large-scale datasets were analyzed: Brain Imaging Data Exchange I II Lifespan Human Connectome Project Development (aged 5–22 years). The principal connectivity gradient representing was estimated using diffusion map embedding. By applying normative modeling generalized additive model for location, scale, shape (GAMLSS), captured nonlinear trajectories developing gradient, as well individual-level deviations typical development based on centile scores measured curves. A whole-brain summary metric, score, derived to measure extent abnormal maturation Finally, through series mediation analyses, examined potential role network-level connectomic diagnoses Results followed non-linear trajectory, showing delayed during childhood compared that typically individuals, an accelerated “catch-up” phase adolescence subsequent decline young adulthood. nature these varied networks, attention networks displaying most pronounced childhood, while particularly default mode network (DMN), remaining impaired adolescence. Mediation analyses revealed persistent reduction DMN segregation throughout key contributor atypical Limitations uneven distribution samples age groups, later stages development, limited our ability fully capture older individuals. Conclusions These findings highlight importance understanding ASD, collectively early interventions aimed at promoting may be critical improving outcomes

Language: Английский

Citations

0
Disrupted Hierarchical Functional Brain Organization in Affective and Psychotic Disorders: Insights from Functional Brain Gradients DOI
Joseph Kambeitz,

H. Häcker,

Linnea Hoheisel

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Patients with psychosis and depression show widespread alterations in brain resting-state functional connectivity (rs-FC), affecting both sensory higher-order regions. In this study, we investigate disruptions the hierarchical organization of networks patients psychotic affective disorders. We derived gradients, low dimensional representations rs-FC that capture cortical hierarchy, a large patient sample including clinical high-risk for (CHR-P) patients, recent-onset (ROP) (ROD) healthy controls (HC). examined regional alterations, network-level differentiation their relationship to symptoms. addition, linked case-control differences receptor expression maps explore underlying neurobiological mechanisms. All groups exhibited visual-to-sensorimotor gradient, while only ROP showed association-to-sensory gradient. CHR-P lower values ventral attention network. Additionally, combined higher somatomotor network, reduced gradient range altered between-network dispersion. ROD within-network dispersion attentional range. Correlational analysis revealed weak associations measures functioning, visual dysfunctions cognition. Furthermore maps, suggesting involvement neurotransmitter systems these disruptions. Our findings reveal transdiagnostic disease-specific organization. These indicate deficits integration across psychiatric diseases, highlighting role disease processes.

Language: Английский

Citations

0