Biologia Futura,
Journal Year:
2023,
Volume and Issue:
75(1), P. 93 - 104
Published: Oct. 27, 2023
Abstract
Neuroimaging
studies
investigating
the
association
between
mental
fatigue
(henceforth
fatigue)
and
brain
physiology
have
identified
many
regions
that
may
underly
cognitive
changes
induced
by
fatigue.
These
focused
on
functional
connectivity
of
relating
to
The
structural
correlates
fatigue,
however,
received
little
attention.
To
fill
this
gap,
study
explored
associations
with
cortical
thickness
frontal
parietal
regions.
In
addition,
we
aimed
explore
reward-induced
improvement
in
performance
neuroanatomical
markers
fatigued
individuals.
Thirty-nine
healthy
volunteers
performed
psychomotor
vigilance
task
for
15
min
(i.e.,
3
time-on-task
blocks
5
min)
out
scanner;
followed
an
additional
rewarded
block
lasting
min.
Baseline
high-resolution
T1-weigthed
MR
images
were
obtained.
Reaction
time
increased
but
got
faster
again
block.
Participants’
subjective
during
performance.
found
higher
increase
was
associated
following
areas:
bilateral
precuneus,
right
precentral
gyrus;
pars
triangularis
left
superior
gyrus.
Our
results
suggest
individual
differences
be
explained
degree
areas
are
motor
processes,
executive
functions,
intrinsic
alertness
parts
default
mode
network.
PLOS mental health.,
Journal Year:
2025,
Volume and Issue:
2(1), P. e0000240 - e0000240
Published: Jan. 24, 2025
Fatigue
is
a
multidimensional
phenomenon.
Although
psychological
tests
can
be
used
to
evaluate
subjective
fatigue,
an
objective
measurement
of
fatigue
needed
mental,
physical,
and
occupational
health
inform
appropriate
interventions.
Heart
rate
variability
(HRV)
has
emerged
as
potential
candidate
for
assessing
mental
fatigue;
however,
its
effectiveness
safety
remain
inconclusive.
To
address
these,
we
conducted
single-center,
randomized
trial
compare
the
efficacy
HRV
with
evaluating
fatigue.
Participants
aged
20
65
years
who
had
received
annual
check-ups
been
found
have
no
concerns
were
included
in
this
study.
We
compared
indexes
after
performing
calculation
task
control
group
that
rested.
The
primary
outcomes
recorded
by
wearable
electrocardiography
intervention
consisting
task.
Subjective
measures
(visual
analog
scale
[VAS]
Profile
Mood
States
2nd
Edition
[POMS2])
evaluated
secondary
outcomes.
One
hundred
forty
participants
into
groups.
performed
lower
square
root
mean
squared
differences
between
successive
RR
intervals
(RMSSD),
absolute
power
high-frequency
band,
standard
deviation
Poincaré
plot.
In
tests,
demonstrated
significantly
higher
scores
on
VAS
POMS2.
Multiple
comparisons
RMSSD
from
indexes,
total
mood
disturbance
POMS2
revealed
significant
indicators
associated
On
other
hand,
vectors
differed
based
component
analysis.
identified
RMSSD,
index,
related
Journal of Neurology,
Journal Year:
2024,
Volume and Issue:
271(9), P. 6388 - 6392
Published: July 5, 2024
Fatigue
is
a
common
and
debilitating
symptom
in
multiple
sclerosis
(MS).
However,
after
over
100
years
of
inquiry
its
definition,
measurement
understanding
remains
elusive.
This
paper
describes
the
challenges
clinicians
researchers
face
when
assessing
treating
MS
patients,
as
well
our
neural
mechanisms
involved
fatigue.
Challenges
for
future
are
discussed.
Biological Psychology,
Journal Year:
2023,
Volume and Issue:
185, P. 108727 - 108727
Published: Dec. 4, 2023
Fatigue-specific
changes
in
the
autonomic
nervous
system
are
often
assumed
to
underlie
development
of
mental
fatigue
caused
by
prolonged
cognitive
tasks
(i.e.
Time-on-Task).
Therefore,
several
previous
studies
have
chosen
investigate
Time-on-Task
related
heart
rate
variability
(HRV).
However,
used
many
different
HRV
indices,
and
their
results
show
inconsistencies.
The
present
study,
therefore,
systematically
reviewed
empirical
with
healthy
individuals
which
is
induced
tasks.
Articles
relevant
objectives
were
searched
selected
applying
PRISMA
guidelines.
We
screened
360
records
found
on
4
databases
that
19
eligible
for
full
review
accordance
inclusion
criteria.
In
general,
all
(with
exception
two
studies)
significant
increasing
Time-on-Task,
suggesting
a
reliable
marker
fatigue.
most
conclusive
indices
showed
consistent
effect
low
frequency
component
time
domain
particularly
root
mean
square
successive
differences.
typically
an
trend
both
type
measures.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Abstract
Alterations
in
energy
metabolism
may
drive
fatigue
older
age,
but
prior
research
primarily
focused
on
skeletal
muscle
energetics
without
assessing
other
systems,
and
utilized
self-reported
measures
of
fatigue.
We
tested
the
association
between
brain
an
objective
measure
fatigability
Study
Muscle,
Mobility
Aging
(N=119,
age
76.8±4.0
years,
59.7%
women).
Total
cerebral
metabolic
rate
oxygen
(CMRO
2
)
was
measured
using
arterial
spin
labeling
T
-relaxation
under
tagging
MRI
protocols.
Accelerometry-based
status
during
a
fast-paced
400m
walk
determined
Pittsburgh
Fatigability
Index
(PPFI,
higher=worse).
Confounders
included
energetics,
vivo
spectroscopy
ex
respirometry,
cardiorespiratory
fitness
(VO
peak),
weight,
medication
count,
multimorbidity.
Multivariable
logistic
regression
models
were
used
to
estimate
(odds
ratio
(OR))
CMRO
with
PPFI>0
compared
referent
group
PPFI=0.
Models
first
adjusted
for
sex,
further
confounders.
In
this
sample,
41.2%
had
(median
3.3%
[0.4-8.0%]).
positively
associated
(age
sex
OR=1.61,
95%
CI:
1.06,
2.45,
p=0.03);
adjustment
confounders
attenuated
association.
The
positive
warrants
study
adults.
BMC Complementary Medicine and Therapies,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 14, 2025
Chronic
fatigue
syndrome
(CFS)
is
a
chronic
disease
characterized
by
fatigue,
complex
symptoms
and
long
duration.
It
incurs
significant
economic
costs
every
year.
Qigong
Tuina
therapy
(QTT),
traditional
Chinese
therapy,
skilled
in
the
treatment
of
fatigue.
The
objective
this
study
to
observe
effectiveness
QTT
treating
patients
with
CFS.
A
randomized
controlled
trial
will
recruit
128
be
allocated
randomly
1:1
ratio
either
group
or
cognitive
behavioral
(CBT)
group.
interventions
for
both
groups
carried
out
once
per
week
8
weeks.
Then
4
weeks
follow-up
conducted
all
after
intervention.
primary
outcome
changes
Multidimensional
Fatigue
Inventory
(MFI-20).
Secondary
outcomes
measured
36-Item
Short
Form
Health
Survey
(SF-36),
Pittsburgh
Sleep
Quality
Index
(PSQI),
Hospital
Anxiety
Depression
Scale
(HADS),
functional
magnetic
resonance
imaging
(fMRI).
data
analyzed
at
baseline,
into
intervention,
end
safety
assessed
each
session.
aims
establish
whether
not
inferior
CBT
CFS
patients.
This
provides
vital
information
an
alternative
complementary
aimed
afflicted
Ethical
approval
was
granted
Ethics
Committee
Shanghai
Municipal
Traditional
Medicine
(2023SHL-KY-100–02).
findings
disseminated
through
publications,
conferences,
briefs
professional
organizations.
ChiCTR2400081828,
Clinical
Trial
Registry.
Registered
on
March
13,
2024.
Behavior Research Methods,
Journal Year:
2025,
Volume and Issue:
57(4)
Published: Feb. 26, 2025
Abstract
Mental
fatigue
is
a
transient
psychophysiological
state
characterized
by
impaired
cognition
and
behavior
across
range
of
dynamic
contexts.
Despite
increasing
interest
in
this
phenomenon,
its
(neuro)physiologic
representations
remain
unclear.
This
systematic
review
aimed
to
quantify
the
outcomes
methodologies
used
investigate
mental
laboratory-based
settings.
Across
72
studies
meeting
our
inclusion
criteria,
we
identified
30
unique
physiologic,
four
visual
outcomes,
application
several
neuroimaging
techniques
investigating
neuronal
function.
increased
heart
rate,
systolic
diastolic
blood
pressure,
mean
arterial
low
frequency,
root
square
successive
differences
(RMSSD),
reduced
standard
deviation
normal-to-normal
intervals
(SDNN)
(all
P
≤
0.04)
when
compared
with
controls.
Applying
electroencephalography
delta,
theta,
alpha
bandwidths
may
provide
useful
insights
into
functional
near-infra-red
spectroscopy
right-lateralized
frontoparietal
regions
would
be
helpful
cortical
activity
change
response
fatigue.
More
data
are
needed
methodological
contexts
order
further
determine
(neuro)physiological
manifestations
However,
provides
direction
researchers
will
assist
them
navigating
considering
options
available.
iScience,
Journal Year:
2024,
Volume and Issue:
27(9), P. 110536 - 110536
Published: July 20, 2024
Cognitive
fatigue
(CF)
increases
accident
risk
reducing
performance,
especially
during
complex
tasks
such
as
driving.
We
evaluated
whether
transcranial
random
noise
stimulation
(tRNS)
could
mitigate
CF
and
improve
driving
performance.
In
a
double-blind
study,
thirty
participants
performed
virtual
reality
truck
task
real
(
