Oxytocin reduces subjective fear in naturalistic social contexts via enhancing top-down middle cingulate-amygdala regulation and brain-wide connectivity DOI Creative Commons
Kun Fu,

Shuyue Xu,

Zheng Zhang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

Abstract Accumulating evidence from animal and human studies suggests a fear-regulating potential of the neuropeptide oxytocin (OT), yet clinical translation into novel interventions for pathological fear requires behavioral neurofunctional characterization under close-to-real life conditions. Here, we combined naturalistic fMRI-design inducing high immersive experience in social non-social contexts with preregistered between-subjects randomized double-blind placebo-controlled intranasal OT trial (24 IU, n = 67 healthy men). reduced subjective small or moderate effect sizes, respectively. In contexts, enhanced left middle cingulate cortex (lMCC) activation its functional connectivity contralateral amygdala, both neural indices significantly inversely associated following OT. On network level, communication between dorsal attention (DAN) fronto-parietal (FPN) default-mode (DMN) as well on more fine-grained level brain-wide communication. These findings indicate fear-reducing conditions pronounced effects suggesting treatment value disorders context-related excessive fear.

Language: Английский

Personalized emotion analysis based on fuzzy multi-modal transformer model DOI
Jianbang Liu, Mei Choo Ang, Jun Kit Chaw

et al.

Applied Intelligence, Journal Year: 2024, Volume and Issue: 55(3)

Published: Dec. 27, 2024

Language: Английский

Citations

0
Oxytocin reduces subjective fear in naturalistic social contexts via enhancing top-down middle cingulate-amygdala regulation and brain-wide connectivity DOI Creative Commons
Kun Fu,

Shuyue Xu,

Zheng Zhang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

Abstract Accumulating evidence from animal and human studies suggests a fear-regulating potential of the neuropeptide oxytocin (OT), yet clinical translation into novel interventions for pathological fear requires behavioral neurofunctional characterization under close-to-real life conditions. Here, we combined naturalistic fMRI-design inducing high immersive experience in social non-social contexts with preregistered between-subjects randomized double-blind placebo-controlled intranasal OT trial (24 IU, n = 67 healthy men). reduced subjective small or moderate effect sizes, respectively. In contexts, enhanced left middle cingulate cortex (lMCC) activation its functional connectivity contralateral amygdala, both neural indices significantly inversely associated following OT. On network level, communication between dorsal attention (DAN) fronto-parietal (FPN) default-mode (DMN) as well on more fine-grained level brain-wide communication. These findings indicate fear-reducing conditions pronounced effects suggesting treatment value disorders context-related excessive fear.

Language: Английский

Citations

0