The neuroanatomy of multi-target attention: Insights from multivariate and Bayesian lesion analyses in acute stroke DOI Open Access
Christoph Sperber, Daniel Wiesen, Hans‐Otto Karnath

et al.

Published: July 4, 2023

Multi-target attention, i.e. the ability to attend and respond multiple visual targets presented simultaneously across both fields, is essential for everyday real-world behaviour. Given close link between neuropsychological deficit of extinction attentional limits in healthy subjects, investigating anatomy that underlies uniquely capable providing important insights concerning critical normal multi-target attention. Previous studies into brain areas attention its failure patients have, however, produced heterogeneous results. In current study, we used multivariate Bayesian lesion analysis approaches investigate anatomical substrate a large sample 108 acute stroke patients. The use patient data multivariate/Bayesian allowed us address limitations associated with previous so obtain more complete picture functional network extinction. Our results demonstrate temporo-parietal junction (TPJ) critically additionally implicated intraparietal sulcus (IPS), line neurologically participants highlighted IPS as area findings resolve seemingly conflicting findings, emphasise urgent need further research clarify precise cognitive role TPJ

Language: Английский

Visual feature processing in a large stroke cohort: evidence against modular organization DOI Creative Commons
Selma Lugtmeijer, Alicja Sobolewska,

Anouk R Smits

et al.

Brain, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Mid-level visual processing represents a crucial stage between basic sensory input and higher-level object recognition. The conventional model posits that fundamental qualities like color motion are processed in specialized, retinotopic brain regions (e.g., V4 for color, MT/V5 motion). Using atlas-based lesion-symptom mapping disconnectome maps cohort of 307 ischemic stroke patients, we examined the neuroanatomical correlates underlying eight mid-level qualities. Contrary to standard model's predictions, our results did not reveal consistent relationships impairments damage traditionally associated regions. While validated methodology by confirming established relationship field defects primary areas (V1, V2, V3), found no reliable evidence linking deficits specific posterior brain. These findings challenge traditional modular view suggest may be more distributed across neural networks than previously thought. This supports alternative models where represent constellations co-occurring information rather

Language: Английский

Citations

1
Lesion mapping in neuropsychological research: A practical and conceptual guide DOI Creative Commons
Margaret Jane Moore, Nele Demeyere, Chris Rorden

et al.

Cortex, Journal Year: 2023, Volume and Issue: 170, P. 38 - 52

Published: Oct. 20, 2023

Language: Английский

Citations

12
No evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson’s disease DOI Creative Commons
Philipp Alexander Loehrer, Wibke Schumacher, Stefanie T. Jost

et al.

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: April 26, 2024

Abstract Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy in advanced Parkinson’s disease (PD). Motor and non-motor outcomes, however, show considerable inter-individual variability. Preoperative morphometry-based metrics have recently received increasing attention to explain treatment effects. As evidence for prediction outcomes limited, we sought investigate association between voxel-based morphometry short-term following STN-DBS this prospective open-label study. Forty-nine PD patients underwent structural MRI a comprehensive clinical assessment at preoperative baseline 6-month follow-up. Voxel-based was used assess associations cerebral volume corrected multiple comparisons using permutation-based approach. We replicated existing results associating loss superior frontal cortex with subpar motor outcomes. Overall burden, not significantly associated morphometric features, limiting its use as marker inform patient selection holistic counselling.

Language: Английский

Citations

3
The neuroanatomy of visual extinction following right hemisphere brain damage: Insights from multivariate and Bayesian lesion analyses in acute stroke DOI Creative Commons
Christoph Sperber, Daniel Wiesen, Hans‐Otto Karnath

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(4)

Published: March 1, 2024

Abstract Multi‐target attention, that is, the ability to attend and respond multiple visual targets presented simultaneously on horizontal meridian across both fields, is essential for everyday real‐world behaviour. Given close link between neuropsychological deficit of extinction attentional limits in healthy subjects, investigating anatomy underlies uniquely capable providing important insights concerning critical normal multi‐target attention. Previous studies into brain areas attention its failure patients have, however, produced heterogeneous results. In current study, we used multivariate Bayesian lesion analysis approaches investigate anatomical substrate a large sample 108 acute right hemisphere stroke patients. The use patient data multivariate/Bayesian allowed us address limitations associated with previous so obtain more complete picture functional network extinction. Our results demonstrate temporo‐parietal junction (TPJ) critically additionally implicated intraparietal sulcus (IPS), line neurologically participants highlighted IPS as area findings resolve seemingly conflicting findings, emphasise urgent need further research clarify precise cognitive role TPJ

Language: Английский

Citations

2
Spatial neglect after subcortical stroke: sometimes a cortico-cortical disconnection syndrome DOI
Christoph Sperber, Hannah Rosenzopf, Max Wawrzyniak

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 28, 2024

Abstract Background and Objectives Spatial neglect is commonly attributed to lesions of a predominantly right-hemispheric cortical network. Although spatial was also repeatedly observed after the basal ganglia thalamus, many anatomical network models omit these structures. We investigated if disruption functional or structural connectivity can explain in subcortical stroke. Methods retrospectively data first-ever, acute stroke patients with right-sided (n = 27) thalamus 16). Based on lesion location, we estimated i) via lesion-network mapping normative resting state fMRI data, ii) white matter disconnection iii) tract-wise association fibres based tractography investigate measures. Results Apart from very small clusters inferior/middle frontal regions symptom for lesions, our analyses found no evidence subcortico-cortical disconnection. Instead, multivariate consideration load several predicted occurrence (p 0.0048; AUC 0.76), which were superior longitudinal fasciculus, inferior occipitofrontal uncinate fasciculus. Conclusion Disconnection long (cortico-cortical) Like competing theory remote hypoperfusion, this mechanism does not require assumption genuine role grey structures neglect.

Language: Английский

Citations

2
Neuroanatomy of reduced distortion of body-centred spatial coding during body tilt in stroke patients DOI Creative Commons
Keisuke Tani,

Shintaro Iio,

Masato Kamiya

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 22, 2023

Abstract Awareness of the direction body’s (longitudinal) axis is fundamental for action and perception. The perceived body orientation strongly biased during tilt; however, neural substrates underlying this phenomenon remain largely unknown. Here, we tackled issue using a neuropsychological approach in patients with hemispheric stroke. Thirty-seven stroke 20 age-matched healthy controls adjusted visual line longitudinal when was upright or laterally tilted by 10 degrees. bias caused tilt, termed tilt-dependent error (TDE), compared between groups. TDE significantly smaller (i.e., less affected performance tilt) group (15.9 ± 15.9°) than control (25.7 17.1°). Lesion subtraction analysis Bayesian lesion-symptom inference revealed that abnormally reduced TDEs were associated lesions right occipitotemporal cortex, such as superior middle temporal gyri. Our findings contribute to better understanding neuroanatomy body-centred spatial coding whole-body tilt.

Language: Английский

Citations

2
Bayesian evidence for the neural dissociation between finger and hand imitation skills DOI Open Access
Hannah Rosenzopf, Lisa Röhrig,

Georg Goldenberg

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 24, 2024

Abstract Introduction For limb apraxia ‒ a heterogeneous disorder of higher motor cognition following stroke an enduring debate has arisen regarding the existence dissociating neural correlates for finger and hand gestures in left hemisphere. We re-assessed this question asking whether previous attempts analysing pooled samples patients with deficits only one both imitation types might have led to systematically biased results. Methods conducted frequentist Bayesian, voxelwise regionwise lesion symptom mappings on sample (N=96) subsamples containing shared isolated respective controls. Results Anatomical analyses reinforced cortical dissociation (located more anteriorly) posteriorly). The presence did indeed dilute associations that appeared stronger samples. Also, brain regions truly associated showed positive bias deficits, when contained deficits. In addition, our parameters uncovered some Bayesian evidence supported reverse (damage protecting from rather than increasing deficit). Discussion Joint do lead biases, which may explain why studies failed detect actual between

Language: Английский

Citations

0
Control without cause: How covariate control biases our insights into brain architecture and pathology DOI Open Access
Christoph Sperber, Laura Gallucci, Marcel Arnold

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 15, 2024

Abstract Inferential analysis of normal or pathological brain imaging data – as in mapping the identification neurological markers is often controlled for secondary variables. However, a rationale covariate control rarely given and formal criteria to identify appropriate covariates such complex are lacking. We investigated impact adequacy large-scale using example stroke lesion-deficit mapping. In 183 patients, we evaluated age, sex, hypertension, lesion volume when real simulated deficits. found that varies can be strong, but it does not necessarily improve precision results. Instead, systematically shifts results towards inversed associations between features covariate. This effect bias and, shown another experiment, even create effects out nothing. The widespread use statistical clinical likely, other biological high-dimensional well may generally results, just change them. Therefore, constitutes problematic degree freedom justified at all.

Language: Английский

Citations

0
Cerebral small vessel disease and stroke: Linked by stroke aetiology, but not stroke lesion location or size DOI Creative Commons
Christoph Sperber, Arsany Hakim, Laura Gallucci

et al.

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2024, Volume and Issue: 33(4), P. 107589 - 107589

Published: Jan. 20, 2024

BackgroundCerebral small vessel disease (SVD) has previously been associated with worse stroke outcome, vascular dementia, and specific cognitive deficits. The underlying causal mechanisms of these associations are not yet fully understood. We investigated whether a relationship between SVD certain aetiologies or lesion anatomy provides potential explanation.MethodsIn retrospective observational study, we examined 859 patients first-ever, non-SVD anterior circulation ischemic (age = 69.0±15.2). evaluated MRI imaging markers to assess an burden score mapped lesions on diffusion-weighted MRI. the association i) aetiology, ii) using topographical statistical mapping.ResultsWith increasing burden, cardioembolic aetiology was more frequent (ρ=0.175; 95%-CI=0.103;0.244), whereas cervical artery dissection (ρ=-0.143; 95%-CI=-0.198;-0.087) patent foramen ovale (ρ=-0.165; 95%-CI=-0.220;-0.104) were less etiologies. However, no significant remained after additionally controlling for age (all p>0.125). Lesion-symptom-mapping Bayesian statistics showed that size.ConclusionsIn high SVD, is likely be caused by aetiology. common risk factor advanced may link both pathologies explain some existing stroke. related location.

Language: Английский

Citations

0
The neuroanatomy of multi-target attention: Insights from multivariate and Bayesian lesion analyses in acute stroke DOI Open Access
Christoph Sperber, Daniel Wiesen, Hans‐Otto Karnath

et al.

Published: July 4, 2023

Multi-target attention, i.e. the ability to attend and respond multiple visual targets presented simultaneously across both fields, is essential for everyday real-world behaviour. Given close link between neuropsychological deficit of extinction attentional limits in healthy subjects, investigating anatomy that underlies uniquely capable providing important insights concerning critical normal multi-target attention. Previous studies into brain areas attention its failure patients have, however, produced heterogeneous results. In current study, we used multivariate Bayesian lesion analysis approaches investigate anatomical substrate a large sample 108 acute stroke patients. The use patient data multivariate/Bayesian allowed us address limitations associated with previous so obtain more complete picture functional network extinction. Our results demonstrate temporo-parietal junction (TPJ) critically additionally implicated intraparietal sulcus (IPS), line neurologically participants highlighted IPS as area findings resolve seemingly conflicting findings, emphasise urgent need further research clarify precise cognitive role TPJ

Language: Английский

Citations

0