
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 17, 2024
Language: Английский
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 17, 2024
Language: Английский
JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(5), P. e2410441 - e2410441
Published: May 8, 2024
This cohort study explores variability in neurodevelopment across sociodemographic factors among youths.
Language: Английский
Citations
0bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 1, 2024
Abstract Humans and nonhuman primate studies suggest that timing tempo of cortical development varies neuroanatomically along a sensorimotor-to-association (S-A) axis. Prior human have reported principal S-A axis across various modalities, but largely rely on cross-sectional samples with wide age-ranges. Here, we investigate developmental changes individual variability in organization the between ages 9-13 years using large, longitudinal sample (N = 2487-3747, 46-50% female) from Adolescent Brain Cognitive Development Study (ABCD Study®). This work assesses multiple aspects neurodevelopment indexed by thickness, microarchitecture, resting-state functional fluctuations. First, evaluated age-related and, then, computed individual-level alignment brain assessing differences therein due to age, sex, puberty. Varying degrees linear quadratic were identified Yet, these patterns overshadowed considerable alignment. Even within individuals, there was little correspondence patterning different investigated (i.e., morphology, function). Some variation morphology microarchitecture explained pubertal development. Altogether, this contextualizes prior findings regional age do progress an at group level, while highlighting broad change individuals development, part sex Significance Statement Understanding normative adolescent change, therein, is crucial for disentangling healthy abnormal We used neuroimaging data study several during early adolescence assessed their cerebral cortex. Age curvilinear However, sensorimotor-association varied considerably, driven
Language: Английский
Citations
0bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 19, 2024
Adolescent neuroimaging studies of sex differences in the human brain predominantly examine mean between males and females. This focus on between-groups without probing relative distributions similarities may contribute to both conflation overestimation sexual dimorphism developing brain. We aimed characterize variance macro- micro-structure early adolescence as it pertains at birth using a large sample 9-11 year-olds from Brain Cognitive Development (ABCD) Study (N=7,723). Specifically, for global regional estimates gray white matter volume, cortical thickness, microstructure (i.e., fractional anisotropy diffusivity), we examined: within- between-sex variance, overlap male female distributions, inhomogeneity via Fligner-Killeen test, an analysis (ANOSIM). For completeness, examined these uncorrected (raw) residualized after mixed-effects modeling account age, pubertal development, socioeconomic status, race, ethnicity, MRI scanner manufacturer, total where applicable. The was universally greater than difference (overlap coefficient range: 0.585 - 0.985) ratio within-sex similar (ANOSIM R -0.001 0.117). All subcortical volumes showed significant whereas minority regions anisotropy, diffusivity. Inhomogeneity reduced accounting other sources variance. Overlap coefficients were larger ANOSIM values smaller outcomes, indicating once covariates. Reported adolescent structure be driven by disparities rather binary, sex-based phenotypes. Contrary popular view sexually dimorphic, found more similarity sexes all measurements examined. study builds upon previous findings illustrating importance considering when examining structure.
Language: Английский
Citations
0Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 17, 2024
Language: Английский
Citations
0