Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 4, 2024

Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging two disorders. However, significant heterogeneity most presents challenges for psychopathological interpretation and clinical applicability. Here, we conceptually established a common factor (cb factor) characterize general structure these symptoms, analogous p factor. We identified cb from 12 in depression-anxiety network. Moreover, this could be predicted using edge-centric connectomes with robust generalizability, was characterized by connectome patterns attention frontoparietal networks. In an independent twin cohort, found that were moderately heritable, their genetic connectome-transcriptional markers associated neurobiological enrichment vasculature cerebellar development, particularly during late-childhood-to-young-adulthood periods. Our findings revealed its architectures, which enriched neurogenetic understanding comorbidity. Phenotyping depression anxiety prominently heterogeneous. Authors (cb) model identify homogeneous signatures

Language: Английский

Functional brain connectome-transcriptional landscape linking to transdiagnostic factors of psychopathological symptoms

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 13, 2024

Abstract Transdiagnostic factors are considered promising in elucidating the etiological underpinnings of psychiatric comorbidities, especially anxiety and depression. However, their symptom-centered neurobiological substrates, encompassing genetic macro-micro-molecular brain functional landscape, remain elusive. Here, we develop edge-centric connectome-based predictive models for transdiagnostic depression symptoms (sTDF). These estimated from nonlinear Gaussian topological schemes a nationwide sample twin dataset. Edge-centric connectome was found to be reproducible generalizable neural signatures sTDF, showing high sensitivity neurally representing sTDF similarity patterns attention/frontoparietal networks. Such were moderately heritable. Genetic transcriptional analyses further revealed biological enrichment gene expression these emerging into vessel systems metabolism CMRO2 cerebellar development late-childhood-to-young-adulthood. Our findings shed lights on architectures by clarifying edge-centeric connectome-transcriptional signature.

Language: Английский

Dissociable neurofunctional and molecular characterizations of reward and punishment sensitivity

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract While the hyper-and hypo-reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, lack an overarching neurobiological characterization currently limits their early identifications and neuromodulations. Here we combined microarray data from Allen Human Brain Atlas with a multimodal fMRI approach to uncover signatures RS PS in discovery-replication design (N=655 participants). Both were mapped separately brain, intrinsic functional connectome fronto-striatal network encoding reward responsiveness, while fronto-insular system was particularly engaged sensitivity. This dissociable patterns related also specific differentiating decisions driven by social monetary motivations. Further imaging transcriptomic analyses revealed that variations for associated topography gene sets enriched ontological pathways, including synaptic transmission, dopaminergic metabolism, immune response stress adaptation. On neurotransmitter level, serotonin neuromodulator identified pivotal hub regulating PS, this process critically dependent on its interactions dopaminergic, opioid GABAergic systems. Overall, these findings indicate neural mapping highlight linkage profiles, which may offer valuable insights into treatment evaluation symptomatology relevant reward/punishment processing deficits.

Language: Английский