Ayahuasca enhances the formation of hippocampal-dependent episodic memory without impacting false memory susceptibility in experienced ayahuasca users: An observational study DOI
Manoj K. Doss, Lilian Kloft, Natasha L. Mason

et al.

Journal of Psychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Background: Ayahuasca is an Amazonian brew with 5-HT 2A -dependent psychedelic effects taken by religious groups globally. Recently, psychedelics have been shown to impair the formation of recollections (hippocampal-dependent episodic memory for specific details) and potentially distort while remembering. However, spare or enhance familiarity-based (cortical-dependent feeling knowing that a stimulus has processed). Aims: Given growing literature on plasticity-promoting psychedelics, we investigated acute impact ayahuasca recollection, familiarity, false in observational study 24 Santo Daime members >500 lifetime uses average. Methods: Participants completed task at baseline after they consumed self-selected dose prepared their church (average contained 3.36 170.64 mg N,N-dimethyltryptamine β-carbolines, respectively). Results: Surprisingly, pre-encoding administration enhanced hit rates, accuracy, recollection but had no familiarity memory. Although practice cannot be discounted, these enhancements were large selective, as multiple measures metamemory did not improve across testing sessions. β-carboline activity accounted this enhancement diverges from past research. estimates generally elevated conditions compared work, alluding consequence frequently driving cortical plasticity. Conclusions: When encoding retrieval took place under experienced users, susceptibility distortions increase, owing accuracy.

Language: Английский

General anaesthesia decreases the uniqueness of brain functional connectivity across individuals and species DOI Creative Commons
Andrea I. Luppi, Daniel Golkowski, Andreas Ranft

et al.

Nature Human Behaviour, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract The human brain is characterized by idiosyncratic patterns of spontaneous thought, rendering each uniquely identifiable from its neural activity. However, deep general anaesthesia suppresses subjective experience. Does it also suppress what makes unique? Here we used functional MRI scans acquired under the effects anaesthetics sevoflurane and propofol to determine whether anaesthetic-induced unconsciousness diminishes uniqueness brain, both with respect brains other individuals another species. Using connectivity, report that individual become less self-similar distinguishable other. Loss distinctiveness highly organized: co-localizes archetypal sensory–association axis, correlating genetic morphometric markers phylogenetic differences between humans primates. This effect more evident at greater anaesthetic depths, reproducible across reversed upon recovery. Providing convergent evidence, show shifts connectivity closer macaque in a low-dimensional space. Finally, match activity cognitive aggregated Neurosynth meta-analytic engine. Collectively, present results reveal anaesthetized are not only other, but primates, specifically human-expanded regions being most affected anaesthesia.

Language: Английский

Citations

1
Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors DOI Creative Commons
Klemens Egger, Helena D. Aicher, Paul Cumming

et al.

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: Sept. 10, 2024

Abstract The potent hallucinogen N,N- dimethyltryptamine (DMT) has garnered significant interest in recent years due to its profound effects on consciousness and therapeutic psychopotential. DMT is an integral (but not exclusive) psychoactive alkaloid the Amazonian plant-based brew ayahuasca, which admixture of several β -carboline monoamine oxidase A (MAO-A) inhibitors potentiate activity oral DMT, while possibly contributing other respects complex psychopharmacology ayahuasca. Irrespective route administration, alters perception, mood, cognition, presumably through agonism at serotonin (5-HT) 1A/2A/2C receptors brain, with additional actions receptor types overall effects. Due rapid first pass metabolism, nearly inactive orally, but co-administration -carbolines or synthetic MAO-A (MAOIs) greatly increase bioavailability duration action. synergistic MAOIs ayahuasca formulations may promote neuroplasticity, underlies their promising efficacy clinical trials for neuropsychiatric disorders, including depression, addiction, post-traumatic stress disorder. Advances neuroimaging techniques are elucidating neural correlates DMT-induced altered states consciousness, revealing alterations brain activity, functional connectivity, network dynamics. In this comprehensive narrative review, we present a synthesis current knowledge pharmacology neuroscience -carbolines, should inform future research aiming harness full potential.

Language: Английский

Citations

6
The unique neural signature of your trip: Functional connectome fingerprints of subjective psilocybin experience DOI Creative Commons
Hanna M. Tolle, Juan Carlos Farah, Pablo Mallaroni

et al.

Network Neuroscience, Journal Year: 2023, Volume and Issue: 8(1), P. 203 - 225

Published: Nov. 1, 2023

Abstract The emerging neuroscientific frontier of brain fingerprinting has recently established that human functional connectomes (FCs) exhibit fingerprint-like idiosyncratic features, which map onto heterogeneously distributed behavioral traits. Here, we harness brain-fingerprinting tools to extract FC features predict subjective drug experience induced by the psychedelic psilocybin. Specifically, in neuroimaging data healthy volunteers under acute influence psilocybin or a placebo, show that, post administration, FCs become more owing greater intersubject dissimilarity. Moreover, whereas placebo subjects are primarily found frontoparietal network, they concentrate default mode network (DMN). Crucially, isolating latter revealed an pattern predicts and is characterized reduced within-DMN DMN-limbic connectivity, as well increased connectivity between DMN attentional systems. Overall, these results contribute bridging gap psilocybin-mediated effects on behavior, while demonstrating value approach pharmacological neuroimaging.

Language: Английский

Citations

8
Brain fingerprint and subjective mood state across the menstrual cycle DOI Creative Commons
Lorenzo Cipriano, Marianna Liparoti, Emahnuel Troisi Lopez

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 6, 2024

Background Brain connectome fingerprinting represents a recent and valid approach in assessing individual identifiability on the basis of subject-specific brain functional connectome. Although this methodology has been tested validated several neurological diseases, its performance, reliability reproducibility healthy individuals poorly investigated. In particular, impact changes connectivity, induced by different phases menstrual cycle (MC), remains unexplored. Furthermore, although modifications psychological condition women during MC are widely documented, possible link with connectivity Methods We conducted Clinical Connectome Fingerprint (CCF) analysis source-reconstructed magnetoencephalography signals cohort 24 across MC. Results All parameters did not differ according to phases. The peri-ovulatory mid-luteal showed less stable, more variable over time, compared early follicular phase. This difference stability alpha band significantly predicted self-esteem level ( p -value <0.01), mood <0.01) five (environmental mastery, personal growth, positive relations others, purpose life, self-acceptance) six dimensions well-being <0.01, save autonomy). Conclusion These results confirm high CCF as well independence from At same time study provides insights their role affecting women’s subjective state Finally, these share predictive power self-esteem, well-being.

Language: Английский

Citations

2
Robust sub-network fingerprints of brief signals in the MEG functional connectome for single-patient classification DOI

Vasiles Balabanis,

Jiaxiang Zhang, Xianghua Xie

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Recent studies have shown that the Magnetoen-cephalography (MEG) functional connectome is person-differentiable in a same-day recording with as little 20 latent components, showing variability across synchrony measures and spectral bands. Here, we succeed components of on multi-day dataset 43 subjects link it to related clinical applications. By optimizing sub-networks regions 30 seconds broadband signal, find robust fingerprinting performance, several patterns region re-occurrence. From search space 5.72 trillion, 46,071 many more acceptable solutions, minimal duplicates found our optimization. Finally, show each these can identify Parkinson’s patient from healthy mean F1 score 0.716 ± 0.090SD. MEG fingerprints previously been multiple occasions hold rating scales progressive neurodegenerative diseases using much coarser features. Furthermore, may similarly be useful for identifying characteristics age, genetics, cognition.

Language: Английский

Citations

0
Ayahuasca enhances the formation of hippocampal-dependent episodic memory without impacting false memory susceptibility in experienced ayahuasca users: An observational study DOI
Manoj K. Doss, Lilian Kloft, Natasha L. Mason

et al.

Journal of Psychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Background: Ayahuasca is an Amazonian brew with 5-HT 2A -dependent psychedelic effects taken by religious groups globally. Recently, psychedelics have been shown to impair the formation of recollections (hippocampal-dependent episodic memory for specific details) and potentially distort while remembering. However, spare or enhance familiarity-based (cortical-dependent feeling knowing that a stimulus has processed). Aims: Given growing literature on plasticity-promoting psychedelics, we investigated acute impact ayahuasca recollection, familiarity, false in observational study 24 Santo Daime members >500 lifetime uses average. Methods: Participants completed task at baseline after they consumed self-selected dose prepared their church (average contained 3.36 170.64 mg N,N-dimethyltryptamine β-carbolines, respectively). Results: Surprisingly, pre-encoding administration enhanced hit rates, accuracy, recollection but had no familiarity memory. Although practice cannot be discounted, these enhancements were large selective, as multiple measures metamemory did not improve across testing sessions. β-carboline activity accounted this enhancement diverges from past research. estimates generally elevated conditions compared work, alluding consequence frequently driving cortical plasticity. Conclusions: When encoding retrieval took place under experienced users, susceptibility distortions increase, owing accuracy.

Language: Английский

Citations

0