Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: July 25, 2024
To investigate the feasibility and performance of 4D flow MRI accelerated by compressed sensing (CS) for hemodynamic quantification intracranial artery venous sinus.
Language: Английский
Neurotherapeutics, Journal Year: 2025, Volume and Issue: 22(1), P. e00521 - e00521
Published: Jan. 1, 2025
Language: Английский
Citations
1
Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17
Published: Feb. 7, 2025
Recent studies have linked disrupted cerebral hemodynamics, including pulsatility index (PI) and wall shear stress (WSS), with neuroimaging features of small vessel disease (CSVD). Cerebral neurovascular coupling (NVC) dysfunction is an important pathophysiological mechanism CSVD. However, evidence linking the carotid artery hemodynamics to NVC still lacking. This study aimed explore impact PI WSS on cognitive performance in CSVD patients using neuroimaging. included 52 41 healthy controls. Carotid were measured 4D flow magnetic resonance imaging (MRI). was assessed through voxel-wise correlations between blood amplitude low-frequency fluctuations. Multiple linear regression used investigate them. showed elevated C2 C4 segments internal reduced common compared measurements significantly diminished patients. analysis indicated significant impaired as well NVC, but not PI, WSS, scores. Reduced are associated NVC. These findings provide insights into mechanisms underlying suggest that hemodynamic abnormalities may serve indicators early-stage
Language: Английский
Citations
0
Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 1 - 7
Published: Feb. 25, 2025
Language: Английский
Citations
0
NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121141 - 121141
Published: March 1, 2025
Growing evidence suggests that Alzheimer's disease (AD) has been linked with the dysfunction of glymphatic system. Previous studies were primarily cross-sectional and focused on only one specific component, hindering understanding overall function in AD. We evaluated longitudinal changes multiple components system (blood-brain barrier (BBB) transcytolemmal water exchange (TWE) permeability) AD mice. Five female wild-type four 3 × Tg-AD mice from 5 to 13 months age scanned monthly using two non-contrast MRI techniques, water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) diffusion-time-dependent kurtosis imaging (tDKI), yielding BBB TWE permeability. Immunostaining was used evaluate tight junction proteins associated structural integrity, aquaporin 4 (AQP4) related TWE, AQP4 perivascular space (PVS) polarization might represent PVS-parenchyma exchange. The relationship between pathology, as measured by amyloid beta (Aβ) tau deposition, also explored. Our results revealed significantly increased hippocampal permeability mouse brains, consistent histological findings reduced upregulated AQP4, which correlated each other can be predictive Aβ deposition. Impaired PVS found In conclusion, altered mice, these vivo validated pathologically, affect waste clearance neurofluid.
Language: Английский
Citations
0
Academic Radiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17
Published: April 22, 2025
To investigate whether cerebrospinal fluid (CSF) circulation markers alter in patients with probable cerebral amyloid angiopathy (pCAA) and they are associated brain degeneration cognitive impairment. We screened pCAA from the ADNI3 database according to Boston 2.0 Criteria. Fifty-two impairment (26 pCAA; 26 age-sex-matched non-pCAA) cognitively normal control (NC) were included this study. All participants underwent neurological MRI assessments. Choroid plexus (ChP) was segmented using a deep learning-based method its volume extracted. Diffusion tensor imaging analysis along perivascular space (DTI-ALPS) used assess perivenous mobility. AD pathological (Aβ tau) assessed positron emission tomography. Brain parenchymal damage white matter hyperintensities (WMH) atrophy ratio. compared among three groups. Correlations ChP volume, DTI-ALPS index, markers, scales analyzed group. The groups exhibited significant differences scores, biomarkers, markers. Post hoc analyses showed that had significantly higher WMH Aβ tau deposition, lower NC. However, no difference ChPs found Controlling for age, sex, vascular risk factors, partial correlation negative between fraction (r = -0.606, p 0.002). Montreal assessment score -0.492, 0.028). CSF elevated burden impairments CAA.
Language: Английский
Citations
0
Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(12)
Published: Aug. 15, 2024
Abstract The glymphatic system (GS) is a whole‐brain perivascular network, consisting of three compartments: the periarterial and perivenous spaces interposed brain parenchyma. GS dysfunction has been implicated in neurodegenerative diseases, particularly Alzheimer's disease (AD). So far, comprehensive research on humans limited by absence easily accessible biomarkers. Recently, promising non‐invasive methods based magnetic resonance imaging (MRI) along with aquaporin‐4 (AQP4) quantification cerebrospinal fluid (CSF) were introduced for an indirect assessment each compartments. We recruited 111 consecutive subjects presenting symptoms suggestive degenerative cognitive decline, who underwent 3 T MRI scanning including multi‐shell diffusion‐weighted images. Forty nine out also CSF examination CSF‐AQP4. CSF‐AQP4 levels measures—including (PVS) counts volume fraction (PVSVF), white matter free water (FW‐WM) mean kurtosis (MK‐WM), diffusion tensor analysis (DTI‐ALPS) (mean, left right)—were compared among patients AD ( n = 47) other diseases (nAD 24), stable mild impairment (MCI 17) cognitively unimpaired (CU 23) elderly people. Two runs conducted, first all patients; second after dividing both nAD into two subgroups gray atrophy as proxy stage. Age, sex, years education, time included confounding factors analyses. Considering whole cohort, showed significantly higher (exp(b) 2.05, p .005) FW‐WM 1.06, .043) than CU. AQP4 respect to CU 2.98, < .001). less atrophic 2.20, .006; exp(b) 1.08, .019, respectively) 2.66, .002; 1.10, subjects. Higher total 1.59, .013) centrum semiovale PVS 1.89, .016), 1.50, .036) WM PVSVF together lower MK‐WM 0.94, .006), ALPS 0.91, .043; 0.88, .010 observed more In addition, exhibited 3.39, .002) Our results indicate significant changes putative biomarkers dementias, suggesting close interaction between neurodegeneration, case AD. However, usefulness some these standalone indices activity may be hindered their dependence stage structural damage.
Language: Английский
Citations
3
Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15
Published: April 8, 2024
The glymphatic system, a macroscopic waste clearance system in the brain, is crucial for maintaining neural health. It facilitates exchange of cerebrospinal and interstitial fluid, aiding soluble proteins metabolites distributing essential nutrients signaling molecules. Emerging evidence suggests link between dysfunction pathogenesis neurodegenerative disorders, including Alzheimer's, Parkinson's, Huntington's disease. These disorders are characterized by accumulation propagation misfolded or mutant proteins, process which likely involved. Impaired could lead to buildup these toxic contributing neurodegeneration. Understanding system's role provide insights into their pathophysiology pave way new therapeutic strategies. Pharmacological enhancement reduce burden slow disease progression. Neuroimaging techniques, particularly MRI-based methods, have emerged as promising tools studying
Language: Английский
Citations
1
World Neurosurgery, Journal Year: 2024, Volume and Issue: 190, P. 147 - 156
Published: July 11, 2024
Language: Английский
Citations
1
Published: Jan. 1, 2024
We present a modular approach to analyse vascular pulsatile motion based on real-time MR imaging data.To this blood vessels are detected frame-wise using intensity threshold determination in combination with edge detection and outlier filter functions.The found consecutive frames assigned one another according their relative position within the frame.This allows us restrict region of interest (ROI) only contain individual use these ROIs for further analysis.Index Terms-real-time MRI
Language: Английский
Citations
0