Neuron, Journal Year: 2011, Volume and Issue: 69(2), P. 387 - 396
Published: Jan. 1, 2011
Language: Английский
Journal of Autism and Developmental Disorders, Journal Year: 2010, Volume and Issue: 40(10), P. 1227 - 1240
Published: March 1, 2010
Language: Английский
Citations
1101
Nonlinear Biomedical Physics, Journal Year: 2007, Volume and Issue: 1(1)
Published: July 5, 2007
Since the discovery of small-world and scale-free networks study complex systems from a network perspective has taken an enormous flight. In recent years many important properties have been delineated. particular, significant progress made in understanding relationship between structural nature dynamics taking place on these networks. For instance, 'synchronizability' coupled oscillators can be determined by graph spectral analysis. These developments theory inspired new applications field neuroscience. Graph analysis used models neural networks, anatomical connectivity, functional connectivity based upon fMRI, EEG MEG. studies suggest that human brain modelled as network, may structure both at level well connectivity. This is hypothesized to reflect optimal situation associated with rapid synchronization information transfer, minimal wiring costs, balance local processing global integration. The topological probably restrained genetic factors, but modified during tasks. There also increasing evidence various types disease such Alzheimer's disease, schizophrenia, tumours epilepsy deviations topology pattern.
Language: Английский
Citations
1000
Cell, Journal Year: 2011, Volume and Issue: 147(1), P. 235 - 246
Published: Sept. 1, 2011
Language: Английский
Citations
989
Science, Journal Year: 2007, Volume and Issue: 318(5847), P. 71 - 76
Published: Sept. 7, 2007
Autism spectrum disorders (ASDs) are characterized by impairments in social behaviors that sometimes coupled to specialized cognitive abilities. A small percentage of ASD patients carry mutations genes encoding neuroligins, which postsynaptic cell-adhesion molecules. We introduced one these into mice: the Arg451-->Cys451 (R451C) substitution neuroligin-3. R451C mutant mice showed impaired interactions but enhanced spatial learning Unexpectedly, behavioral changes were accompanied an increase inhibitory synaptic transmission with no apparent effect on excitatory synapses. Deletion neuroligin-3, contrast, did not cause such changes, indicating represents a gain-of-function mutation. These data suggest increased may contribute human ASDs and knockin be useful model for studying autism-related behaviors.
Language: Английский
Citations
974
Neuron, Journal Year: 2013, Volume and Issue: 80(3), P. 751 - 764
Published: Oct. 1, 2013
Language: Английский
Citations
856
Journal of Neuroscience, Journal Year: 2008, Volume and Issue: 28(24), P. 6165 - 6173
Published: June 11, 2008
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severe Parkinson9s disease (PD), but its mechanism action unclear. Exaggerated oscillatory synchronization in β (13–30 Hz) frequency band has been associated bradykinesia PD. Accordingly, we tested hypothesis that clinical benefit exerted by STN HFS accompanied suppression local activity. To this end, explored after effects on field potential (LFP) activity recorded from immediately cessation 11 PD patients. Only demonstrated temporary persistence were analyzed. led to significant reduction LFP 12 s end and decrease motor cortical–STN coherence over same time period. The correlated movement amplitude during simple task, so smaller amount was better task performance. These features absent when power 5–12 Hz considered. Our findings suggest may act modulating pathological patterns synchronized oscillations, specifically
Language: Английский
Citations
804
Physiological Reviews, Journal Year: 2017, Volume and Issue: 97(4), P. 1619 - 1747
Published: Sept. 28, 2017
In the hippocampus GABAergic local circuit inhibitory interneurons represent only ~10–15% of total neuronal population; however, their remarkable anatomical and physiological diversity allows them to regulate virtually all aspects cellular function. Here we provide an overview current state field interneuron research, focusing largely on hippocampus. We discuss recent advances related various cell types, including development maturation, expression subtype-specific voltage- ligand-gated channels, roles in network oscillations. also technological approaches that have permitted high-resolution, examination numerous neural disorders emerging therapeutic strategies ameliorate such pathophysiological conditions. The ultimate goal this review is not a touchstone for field, but help pave way future research by highlighting where gaps our knowledge exist how complete appreciation will aid strategies.
Language: Английский
Citations
776
Neuron, Journal Year: 2011, Volume and Issue: 72(2), P. 370 - 384
Published: Oct. 1, 2011
Language: Английский
Citations
764
PLoS ONE, Journal Year: 2010, Volume and Issue: 5(11), P. e13766 - e13766
Published: Nov. 1, 2010
Non-invasive electrical stimulation of the human cortex by means transcranial direct current (tDCS) has been instrumental in a number important discoveries field cortical function and become well-established method for evaluating brain healthy participants. Recently, alternating (tACS) introduced to directly modulate ongoing rhythmic activity application oscillatory currents on scalp. Until now efficiency tACS modulating indicated only inference from perceptual behavioural consequences stimulation. No electrophysiological evidence reported. We delivered over occipital 10 participants entrain neuronal their individual alpha frequency range compared results with those separate group receiving sham The but not elevated endogenous power parieto-central electrodes electroencephalogram. Additionally, network spiking neurons, we simulated how can be affected even after end show that spike-timing-dependent plasticity (STDP) selectively modulates synapses depending resonance frequencies neural circuits they belong to. Thus, influences STDP which turn aftereffects upon activity. present findings are first an interaction cortex. data demonstrate ability specifically its potential both at fostering knowledge functional significance oscillations therapeutic application.
Language: Английский
Citations
760
Frontiers in Human Neuroscience, Journal Year: 2013, Volume and Issue: 7
Published: Jan. 1, 2013
REVIEW article Front. Hum. Neurosci., 14 June 2013Sec. Brain Imaging and Stimulation https://doi.org/10.3389/fnhum.2013.00279
Language: Английский
Citations
728