Interneuron Types as Attractors and Controllers

Annual Review of Neuroscience, Journal Year: 2019, Volume and Issue: 43(1), P. 1 - 30

Published: July 12, 2019

Cortical interneurons display striking differences in shape, physiology, and other attributes, challenging us to appropriately classify them. We previously suggested that interneuron types should be defined by their role cortical processing. Here, we revisit the question of how codify diversity based upon division labor function as controllers information flow. suggest developmental trajectories provide a guide for appreciating argue subtype identity is generated using configurational (rather than combinatorial) code transcription factors produce attractor states underlying gene regulatory network. present our updated three-stage model specification: an initial cardinal step, allocating into few major classes, followed definitive refinement, creating subclasses settling within cortex, lastly, state determination, reflecting incorporation functional circuit ensembles. close discussing findings indicating classes are both evolutionarily ancient conserved. propose complexity circuits phylogenetically old types, complemented evolutionary increase principal neuron diversity. This suggests natural neurobiological definition might derived from match between origin computational function.

Language: Английский

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Human cerebral organoids — a new tool for clinical neurology research

Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(11), P. 661 - 680

Published: Oct. 17, 2022

Language: Английский

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The role of GABAergic signalling in neurodevelopmental disorders

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(5), P. 290 - 307

Published: March 26, 2021

Language: Английский

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The postnatal GABA shift: A developmental perspective

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 124, P. 179 - 192

Published: Feb. 4, 2021

GABA is the major inhibitory neurotransmitter that counterbalances excitation in mature brain. The action of relies on inflow chloride ions (Cl-), which hyperpolarizes neuron. In early development, signaling induces outward Cl- currents and depolarizing. postnatal shift from depolarizing to hyperpolarizing a pivotal event brain development its timing affects function throughout life. Altered associated with several neurodevelopmental disorders. Here, we argue represents final sequence shifts, regulating proliferation, migration, differentiation, finally plasticity developing neurons. Each developmental ensures instructive role matches circumstances network. Sensory input may be crucial factor determining proper shift. A perspective necessary interpret full consequences mismatch between connectivity, activity during development.

Language: Английский

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Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome

Cell stem cell, Journal Year: 2022, Volume and Issue: 29(2), P. 248 - 264.e7

Published: Jan. 5, 2022

Language: Английский

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